Skip to main content

Diphenhydramine

ADVERTISEMENT
Identification
Molecular formula
C17H21NO2
CAS number
58-73-1
IUPAC name
N,N-dimethyl-2-[2-[phenyl-[2-(trifluoromethyl)phenyl]methoxy]ethoxy]ethanamine
State
State

At room temperature, diphenhydramine is a solid.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
439.60
Boiling point (Kelvin)
712.75
General information
Molecular weight
291.35g/mol
Molar mass
291.3530g/mol
Density
1.3009g/cm3
Appearence

Diphenhydramine is typically found as a white, crystalline powder. It is commonly available in tablet, capsule, and liquid form when used as a medication. The powder is odorless and has a bitter taste.

Comment on solubility

Solubility of N,N-dimethyl-2-[2-[phenyl-[2-(trifluoromethyl)phenyl]methoxy]ethoxy]ethanamine

The solubility of N,N-dimethyl-2-[2-[phenyl-[2-(trifluoromethyl)phenyl]methoxy]ethoxy]ethanamine can be influenced by several factors due to its complex structure. This compound features a potentially hydrophobic character because of the multiple aromatic rings and trifluoromethyl group, leading us to consider the following:

  • Hydrophobic Interactions: The presence of phenyl groups may limit solubility in polar solvents like water.
  • Polar Functional Groups: Despite the hydrophobic characteristics, the ethanamine moiety may confer some degree of solubility in polar solvents.
  • Effect of Fluorination: The fluorine atoms in the trifluoromethyl group can introduce unique interactions, which sometimes enhance solubility in certain organic solvents.
  • Temperature Dependency: The solubility can vary significantly with temperature changes, influencing molecular interactions.

In general, compounds similar to this structure are often sparingly soluble in water but may dissolve better in organic solvents like ethanol or acetone, making it crucial to consider the solvent environment in practical applications. As stated, "Solubility is where the action is," so understanding these characteristics will guide experiments and formulations effectively.

Interesting facts

Interesting Facts about N,N-Dimethyl-2-[2-[Phenyl-[2-(Trifluoromethyl)Phenyl]Methoxy]Ethoxy]Ethanamine

N,N-Dimethyl-2-[2-[phenyl-[2-(trifluoromethyl)phenyl]methoxy]ethoxy]ethanamine, commonly referred to in chemical research discussions, is a fascinating compound with various intriguing properties and applications. This compound belongs to the class of amines and showcases complex structural features, giving rise to unique properties.

Key Characteristics

  • Trifluoromethyl Substitution: The presence of a trifluoromethyl group (-CF3) often enhances the lipophilicity and metabolic stability of organic compounds, making them of immense interest in pharmaceutical chemistry.
  • Phenyl Groups: The multiple phenyl rings in the molecule contribute significantly to its electronic properties and can influence the compound's interaction with biological targets.
  • Potential Applications: Compounds with such complex structures are often explored for their potential as drug candidates, particularly in the field of medicinal chemistry.

Scientific Importance

This compound is a great example of how structural modifications can lead to enhanced biological activity. The incorporation of the trifluoromethyl group is especially notable as it frequently increases the affinity of the compound for certain types of receptors, hence making it a potential candidate for further research in therapeutic applications.

Researchers in the field often focus on:

  • Mechanistic studies to uncover how the compound interacts at a molecular level with biological systems.
  • Synthesis methods that can be optimized for higher yields and purity.
  • Pharmacokinetics to better understand the absorption, distribution, metabolism, and excretion (ADME) properties.

As noted by renowned chemists, "The true beauty of organic compounds lies in their potential to serve as key players in biological processes." This sentiment reflects the continuous exploration of compounds like N,N-dimethyl-2-[2-[phenyl-[2-(trifluoromethyl)phenyl]methoxy]ethoxy]ethanamine in developing innovative therapies.

In summary, the multifaceted structure and the presence of a trifluoromethyl group within this compound present vast opportunities for discovery in the realm of medicinal chemistry and beyond.

Synonyms
AM-814/41094487
N,N-dimethyl-N-[2-(2-{phenyl[2-(trifluoromethyl)phenyl]methoxy}ethoxy)ethyl]amine