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DMT

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Identification
Molecular formula
C13H18N4
CAS number
61-50-7
IUPAC name
N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
State
State

At room temperature, it is generally found as a solid. It can be crystalline and has a high tendency to sublimate, developing into a gaseous form at temperatures slightly above room temperature with adequate conditions.

Melting point (Celsius)
49.50
Melting point (Kelvin)
322.65
Boiling point (Celsius)
160.50
Boiling point (Kelvin)
433.65
General information
Molecular weight
188.27g/mol
Molar mass
188.2690g/mol
Density
1.1240g/cm3
Appearence

It occurs as a white crystalline solid, often appearing as fine crystalline particles. In its pure form, it may also exhibit a slight off-white or beige tint when impurities are present. It is typically odorless.

Comment on solubility

Solubility of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine

The solubility characteristics of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine (C13H18N4) can be intriguing, as several factors influence its behavior in different solvents. Here's what is generally observed:

  • Polar Solvents: The compound is likely to possess relatively low solubility in highly polar solvents due to its hydrophobic indole and triazole motifs.
  • Nonpolar Solvents: Conversely, it may exhibit better solubility in nonpolar or slightly polar organic solvents, where the larger nonpolar regions of the molecule can interact favorably.
  • pH Sensitivity: The presence of amine groups suggests that the compound could be affected by pH, with potential alterations in solubility at different pH levels due to protonation states.
  • Temperature Effects: As with many compounds, solubility might increase with temperature, making it essential to consider the conditions under which solubility is measured.
  • Crystallization Behavior: The structural complexity may lead to unique crystallization properties, potentially affecting its dissolution profile in various environments.

In summary, while the solubility of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine may not be straightforward, understanding its interactions with different solvents can provide valuable insights.

Interesting facts

Interesting Facts about N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine

N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine, commonly referred to in research circles for its unique structure and potential applications, is an intriguing compound in the field of medicinal chemistry.

Key Features

  • Pharmaceutical Potential: This compound belongs to a class of drugs that are primarily explored for their potential in treating various diseases, including cancer and fungal infections. The presence of triazole and indole moieties in its structure can contribute to its biological activity.
  • Triazole Component: The triazole ring is known for its role in many pharmacologically active compounds. It has been often utilized in the synthesis of antifungal agents due to its unique nitrogen-containing structure.
  • Indole Derivative: The indole structure is prevalent in many natural products and has been reputed for its diverse pharmacological properties, such as anti-inflammatory and antitumor activities.
  • Dimethylamine Group: The N,N-dimethyl functionality increases lipophilicity, which can enhance the passage of the compound across cellular membranes, potentially leading to improved bioavailability.

Research Insights

Emerging studies suggest that compounds like N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine can target specific pathways in disease mechanisms. These pathways often involve:

  • Cell proliferation
  • Apooptosis modulation
  • Antimicrobial action

Current research continues to explore the compound's full potential, with implications stretching beyond just anticancer and antifungal properties. As chemical scientists dive deeper into its mechanisms, its utilization may expand to address both acute and chronic health conditions.

In conclusion, the study of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine reflects the teeny intricate connection between structure and biological activity in medicinal chemistry. Truly, as Marie Curie would say, "One never notices what has been done; one can only see what remains to be done."

Synonyms
rizatriptan
144034-80-0
Risatriptan
MK 462 free base
2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine
rizatriptanum
1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine
MK-462 FREE BASE
Rizatriptan (INN)
UNII-51086HBW8G
DTXSID2023565
CHEBI:48273
51086HBW8G
N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
CHEMBL905
DIMETHYL({2-[5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL]ETHYL})AMINE
DTXCID103565
N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine
NCGC00095899-01
RIZATRIPTAN [INN]
Rizatriptan [INN:BAN]
Rizatriptan benzoat
L-705126
N,N-dimethyl-2-(5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl)-ethanamine
N,N-dimethyl-2-(5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl)ethanamine
RIZATRIPTAN [MI]
GTPL51
RIZATRIPTAN [VANDF]
SCHEMBL26662
RIZATRIPTAN [WHO-DD]
MLS006010229
BIDD:GT0361
SPECTRUM1505189
N02CC04
BCP28039
Tox21_111534
BDBM50033437
STL484039
AKOS015896596
AC-1712
DB00953
NCGC00095899-04
NCGC00095899-09
NCGC00095899-15
DS-15263
SMR000469172
SBI-0206745.P001
DB-080717
CAS-144034-80-0
NS00014357
D08485
AB00698277-05
AB00698277-07
AB00698277_08
AB00698277_09
EN300-7382446
L000812
Q212171
BRD-K75699339-057-03-2
BRD-K75699339-057-07-3
BRD-K75699339-057-08-1
BRD-K75699339-057-09-9
Dimethyl-[2-(5-[1,2,4]triazol-1-ylmethyl-1H-indol-3-yl)-ethyl]-amine
N,N-dimethyl-2-(5-(1,2,4-triazol-1-ylmethyl)-1H-indole-3-yl)ethylamine
N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl] ethylamine
dimethyl(2-{5-[(1H-1,2,4-triazol-1-yl)methyl]-1H-indol-3-yl}ethyl)amine
2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine;N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine