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Vortioxetine

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Identification
Molecular formula
C18H22F3N3
CAS number
508233-74-7
IUPAC name
N,N-dimethyl-2-[5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazol-9-yl]ethanamine
State
State

At room temperature, Vortioxetine is a solid.

Melting point (Celsius)
224.00
Melting point (Kelvin)
497.00
Boiling point (Celsius)
458.50
Boiling point (Kelvin)
731.70
General information
Molecular weight
298.35g/mol
Molar mass
298.3530g/mol
Density
1.2700g/cm3
Appearence

Vortioxetine is a white to light beige powder. It is often supplied in tablet form for medicinal use.

Comment on solubility

Solubility of N,N-dimethyl-2-[5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazol-9-yl]ethanamine

N,N-dimethyl-2-[5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazol-9-yl]ethanamine, with its complex structure, exhibits noteworthy solubility characteristics.

Generally, solubility is influenced by various factors such as:

  • Polarity: The presence of trifluoromethyl groups often enhances the polarity of compounds, thereby affecting solubility in polar solvents.
  • Hydrogen Bonding: This compound may participate in hydrogen bonding, depending on the solvent, which can significantly improve solubility in organic solvents.
  • Interactions: The interactions between the solute and the solvent, including van der Waals forces, can also play a crucial role.

In general, compounds similar to this one tend to be more soluble in organic solvents such as:

  • Dimethyl sulfoxide (DMSO)
  • Acetone
  • Ethyl acetate

However, their solubility in water is usually limited due to:

  • **Hydrophobic regions:** The tetrahydrocarbazole moiety may create hydrophobic regions that do not interact well with water.
  • **Complex structure:** The steric hindrance created by the bulk of the molecule can impede solvation in aqueous environments.

As such, one might say, "Solubility is context-dependent," and empirical tests can provide valuable insights into the solubility behavior of such intricate compounds.

Interesting facts

Interesting Facts about N,N-Dimethyl-2-[5-(Trifluoromethyl)-1,2,3,4-tetrahydrocarbazol-9-yl]ethanamine

N,N-Dimethyl-2-[5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazol-9-yl]ethanamine, a fascinating compound in the realm of organic chemistry, exhibits unique characteristics and applications that are worth exploring:

  • Structural Complexity: This compound contains a tetrahydrocarbazole moiety, which contributes to its structural intricacy. The fusion of the trifluoromethyl group enhances its electronic properties, making it a prime candidate for diverse chemical reactions.
  • Pharmaceutical Potential: Given its unique structure, this compound may play a role in pharmaceutical research, specifically in the development of new classes of drugs. Compounds with similar structures have been investigated for their potential to treat a variety of conditions, including neurodegenerative diseases.
  • Tuning Reactivity: The presence of the trifluoromethyl group often enhances lipophilicity and metabolic stability. This can lead to increased biological activity as well as altered pharmacokinetics, making it a valuable modification in drug design.
  • Research Interest: Chemists are particularly interested in exploring compounds like this one for their ability to act as ligands in coordination chemistry or as intermediates in synthetic pathways.

As researchers continue to investigate the properties and potential applications of this compound, the versatility and significance of N,N-dimethyl-2-[5-(trifluoromethyl)-1,2,3,4-tetrahydrocarbazol-9-yl]ethanamine are sure to become even more apparent. For anyone involved in the field of organic synthesis or drug development, understanding such compounds is crucial for driving innovation.