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Desloratadine

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Identification
Molecular formula
C19H19ClN2
CAS number
100643-71-8
IUPAC name
N,N-dimethyl-2-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)ethanamine
State
State

At room temperature, Desloratadine is typically found in a solid state. It is often handled in powdered form for pharmaceutical formulations.

Melting point (Celsius)
149.00
Melting point (Kelvin)
422.15
Boiling point (Celsius)
473.90
Boiling point (Kelvin)
747.05
General information
Molecular weight
310.47g/mol
Molar mass
310.4690g/mol
Density
1.2150g/cm3
Appearence

Desloratadine is usually found as a white to off-white powder. It is crystalline in nature and known for being almost insoluble in water, but soluble in organic solvents like ethanol and methanol. Its fine powder can disperse in the air, creating the potential for inhalation and requiring careful handling.

Comment on solubility

Solubility of N,N-dimethyl-2-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)ethanamine

N,N-dimethyl-2-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)ethanamine is a compound that exhibits specific solubility characteristics influenced by its structure. Understanding solubility is crucial for applications in pharmaceuticals and chemical formulations.

Factors Affecting Solubility

The solubility of this compound can be affected by several factors:

  • Polarity: The presence of polar functional groups in the compound can enhance its solubility in polar solvents such as water.
  • Hydrogen Bonding: Capable of forming hydrogen bonds may lead to increased solubility in polar solvents.
  • Molecular Weight: Higher molecular weight can sometimes correlate with lower solubility, depending on structure and intermolecular interactions.

Solubility Insights

For N,N-dimethyl-2-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)ethanamine, one may observe:

  • Potential solubility in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol.
  • Limited solubility in water, due to its hydrocarbon-heavy framework.

It's noteworthy that solubility studies are often essential for predicting a compound's bioavailability and therapeutic efficacy. As emphasized, consideration of both solvent properties and the chemical structure can provide insightful predictions regarding the solubility behavior of this compound.

Interesting facts

Interesting Facts about N,N-dimethyl-2-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)ethanamine

This fascinating compound, commonly represented by its structural components, showcases intriguing features that captivate the attention of chemists and researchers alike. Here are some key aspects:

  • Structural Complexity: The compound features a unique bicyclic structure that includes both cyclic amines and sulfur, contributing to its diverse chemical behavior.
  • Pharmacological Potential: Due to the presence of the cycloheptane and quinoline moieties, this compound could potentially exhibit interesting biological activities, which makes it a candidate for drug development.
  • Dimethylamino Group: The dimethylamino group may enhance the solubility and bioavailability of the compound, crucial properties for pharmacological applications.
  • Reactivity: Sulfanyl (thioether) functional groups in organic compounds often increase their nucleophilicity, leading to a variety of possible reactions not seen in similar compounds lacking sulfur.
  • Historical Context: Compounds that include quinoline and its derivatives have a rich history in medicinal chemistry, with many having been used as effective treatments for a range of diseases.

As the field of chemistry continues to explore the potential utility of such complex molecules, N,N-dimethyl-2-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)ethanamine represents a promising frontier in both synthetic and medicinal chemistry. It exemplifies how structural intricacy can lead to unique chemical properties and potential therapeutic applications.

Synonyms
18833-66-4
BRN 1479861
6H-Cyclohepta(b)quinoline, 11-((2-(dimethylamino)ethyl)thio)-7,8,9,10-tetrahydro-
DTXSID90172184
11-((2-(Dimethylamino)ethyl)thio)-7,8,9,10-tetrahydro-6H-cyclohepta(b)quinoline
11-[[2-(Dimethylamino)ethyl]thio]-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline
DTXCID8094675
5-21-03-00530 (Beilstein Handbook Reference)
N,N-dimethyl-2-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)ethanamine