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Diphenhydramine

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Identification
Molecular formula
C17H21NO
CAS number
58-73-1
IUPAC name
N,N-dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine
State
State

At room temperature, diphenhydramine is generally in a solid state, specifically as a powder.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.20
Boiling point (Celsius)
288.10
Boiling point (Kelvin)
561.30
General information
Molecular weight
255.35g/mol
Molar mass
255.3460g/mol
Density
1.0260g/cm3
Appearence

Diphenhydramine typically appears as a white crystalline powder. It is known for being relatively stable and is often found in the form of its hydrochloride salt when used in pharmaceutical formulations.

Comment on solubility

Solubility of N,N-dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine

The solubility of N,N-dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine (C17H21NO) can be influenced by various factors due to its complex structure. Here are some essential points to consider:

  • Polarity: The presence of both hydrophobic aromatic rings and a hydrophilic amine group suggests that this compound may exhibit moderate solubility in organic solvents.
  • Solvent Compatibility: It is likely to be soluble in solvents such as:
    • Alcohols (e.g., ethanol, methanol)
    • Aromatic hydrocarbons (e.g., toluene, xylene)
    • Chloroform
  • Water Solubility: Given its structure, solubility in water may be limited. This is due to the overall hydrophobic character imparted by the aromatic rings compared to the more hydrophilic amine group.
  • Temperature Effects: Like many organic compounds, solubility can increase with temperature, which may enhance the overall dissolution in organic solvents.

In conclusion, while N,N-dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine may not be highly soluble in water, its solubility profile in organic solvents can provide valuable insights for practical applications and experimenting conditions.

Interesting facts

Interesting Facts about N,N-Dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine

N,N-Dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine is an intriguing compound known for its unique structure and applications in the field of chemistry. Here are some fascinating insights:

  • Structural Complexity: This compound features an intricate arrangement, incorporating both o-tolyl and phenyl groups on a central ethanamine structure, which contributes to its varied reactivity and stability.
  • Potential Applications: The compound has shown promise in pharmaceuticals and medicinal chemistry, specifically as a potential reagent or intermediate in synthesizing various therapeutic agents.
  • Mechanism of Action: Due to the presence of the methoxy group, this compound may engage in diverse interactions with biological targets, which is a crucial aspect in drug design.
  • Research Interest: Compounds like this one are gaining traction in scientific research, particularly in studies focusing on the neuropharmacological effects of substituted amines.
  • Synthetic Pathways: Chemists are particularly fascinated by the synthetic routes that can lead to this compound, exploring methodologies that enhance yield and purity, while minimizing environmental impact.

In summary, N,N-dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine presents a unique opportunity for exploration within both synthetic and medicinal chemistry. The combination of its structural features and potential applications makes it a subject of ongoing research and interest.

Synonyms
orphenadrine
Orphenadrin
83-98-7
Orphenadine
o-Methyldiphenhydramine
Disipal
Orphenedrine
Orfenadrina
2-Methyldiphenhydramine
Mefenamine
Orphenadinum
Orphenadrinum
Brocadisipal
o-Monomethyldiphenhydramine
2-(Phenyl-o-tolylmethoxy)ethyldimethylamine
Invagesic
N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethanamine
Mialgin
Phenyl-o-tolylmethyl dimethyaminoethyl ether
WS 2434
Orfenadrina [INN-Spanish]
Orphenadrinum [INN-Latin]
beta-Dimethylaminoethyl 2-methylbenzhydryl ether
Orphengesic
Norgesic
HSDB 3139
EINECS 201-509-2
UNII-AL805O9OG9
beta-Dimethylaminoethyl-2-methylbenzhydryl ether
N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine
BRN 1885151
AL805O9OG9
CHEBI:7789
N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamin
N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyl)oxy)ethylamine
Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-
CHEMBL900
N,N-dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine
dimethyl({2-[(2-methylphenyl)(phenyl)methoxy]ethyl})amine
ORP
DTXSID3023396
4-06-00-04727 (Beilstein Handbook Reference)
Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine
Orphenadrine (INN)
Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-
N,N-Dimethyl-2-[(o-methyl-alpha-phenylbenzyl)oxy]ethylamine
Orphenate
Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-
Methyldiphenylhydramine
ORPHENADRINE [INN]
Orfenadrina (INN-Spanish)
Orphenadrinum (INN-Latin)
Orphenadrine [INN:BAN]
N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine
ETHANAMINE, N,N-DIMETHYL-2-((2-METHYLPHENYL)PHENYLMETHOXY)-, (+/-)-
Mialgin (TN)
Dimethyl-(2-(phenyl-o-tolyl-methoxy)-ethyl)-amine
N,N-dimethyl-2-((2-methylphenyl)(phenyl)methoxy)ethanamine
N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)ethylamine
Spectrum_001045
Brocasipal (Salt/Mix)
Mephenamine (Salt/Mix)
MEFENAMINE [JAN]
Prestwick0_000239
Prestwick1_000239
Prestwick2_000239
Prestwick3_000239
Spectrum2_001038
Spectrum3_000531
Spectrum4_000460
Spectrum5_001036
ORPHENADRINE [MI]
Phenyl-o-tolylmethyl dimethylaminoethyl ether
ORPHENADRINE [HSDB]
ORPHENADRINE [VANDF]
Lopac0_000884
Oprea1_476547
SCHEMBL28727
BSPBio_000317
BSPBio_002141
CBDivE_006102
KBioGR_000880
KBioSS_001525
DivK1c_000853
ORPHENADRINE [WHO-DD]
SPBio_001255
SPBio_002238
BPBio1_000349
DTXCID003396
GTPL7251
KBio1_000853
KBio2_001525
KBio2_004093
KBio2_006661
KBio3_001641
M03BC01
N04AB02
NINDS_000853
N,N-dimethyl-2-{[(2-methylphenyl)(phenyl)methyl]oxy}ethanamine
BDBM50062614
BS-5930
CCG-204966
DB01173
SDCCGSBI-0050859.P005
IDI1_000853
NCGC00015771-03
NCGC00015771-05
NCGC00015771-06
NCGC00015771-07
NCGC00015771-09
NCGC00015771-10
NCGC00015771-12
NCGC00015771-22
NCGC00089814-02
NCGC00089814-03
NCGC00089814-05
SBI-0050859.P004
HY-157959
AB00053510
CS-1010546
NS00009478
C07935
D08305
dimethyl-2[alpha-(o-tolyl)benzyloxy]ethylamine
EN300-708773
AB00053510-19
AB00053510_20
AB00053510_21
.beta.-Dimethylaminoethyl 2-methylbenzhydryl ether
L001253
Q3292273
BRD-A53576514-003-03-1
BRD-A53576514-048-06-9
BRD-A53576514-048-13-5
BRD-A53576514-048-14-3
N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine #
N,N-Dimethyl-2-[(o-methyl-.alpha.-phenylbenzyl)oxy]ethylamine
Ethylamine, N,N-dimethyl-2-((o-methyl-.alpha.-phenylbenzyl)oxy)-
(+/-)-N,N-DIMETHYL-2-((O-METHYL-alpha-PHENYLBENZYL)OXY)ETHYLAMINE
(+/-)-N,N-DIMETHYL-2-((O-METHYL-.ALPHA.-PHENYLBENZYL)OXY)ETHYLAMINE
201-509-2