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Diphenhydramine Hydrochloride

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Identification
Molecular formula
C17H21NO.HCl
CAS number
147-24-0
IUPAC name
N,N-dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine;hydrochloride
State
State

At room temperature, diphenhydramine hydrochloride is typically found as a solid.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
473.60
Boiling point (Kelvin)
746.80
General information
Molecular weight
291.82g/mol
Molar mass
291.8170g/mol
Density
1.0830g/cm3
Appearence

Diphenhydramine hydrochloride appears as a white crystalline powder with no distinctive odor. It is often used in its solid form for medicinal purposes.

Comment on solubility

Solubility of N,N-Dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine Hydrochloride

The solubility of N,N-dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine;hydrochloride can be influenced by various factors due to its unique structure. Hydrochloride salts, like this compound, are typically more soluble in aqueous solutions compared to their base counterparts. Here are some key aspects regarding its solubility:

  • Polarity: Given the presence of a hydrochloride group, this compound may exhibit enhanced solubility in polar solvents such as water.
  • Temperature Effect: Solubility often increases with temperature; therefore, higher temperatures may be advantageous for dissolving this compound in solvent systems.
  • pH Dependence: The solubility can vary with pH levels, as the ionization state of the amine group can change, affecting its overall solubility.
  • Solvent Choice: Apart from water, other solvents such as ethanol or dimethyl sulfoxide (DMSO) may also dissolve this compound due to their own polar characteristics.

In general, when estimating solubility, it is crucial to consider the compound's molecular structure and the nature of the solvent. As a rule of thumb, "like dissolves like" remains a guiding principle in determining solubility behaviors.

Interesting facts

Interesting Facts about N,N-Dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine Hydrochloride

N,N-Dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine hydrochloride is a fascinating compound that exemplifies the intricate world of organic chemistry and pharmaceuticals. Here are some key points that make this compound particularly noteworthy:

  • Versatile Applications: This compound is utilized in various fields, especially in medicinal chemistry, where its unique structure contributes to its biological activity.
  • Complex Structure: Its molecular architecture is intriguing, featuring a dimethylamino group, which is known for its basic properties, and an ether linkage that enhances its stability and reactivity.
  • Ray of Hope: Compounds like N,N-dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine hydrochloride hold promise in drug development, potentially offering therapeutic options for treating neurological disorders due to their interaction with neurotransmitter systems.
  • Research Fascination: Scientists are often drawn to this compound for its ability to modulate receptor activity, making it a valuable subject of study in drug discovery and pharmacology.
  • Safety and Handling: As with many hydrochloride salts, this compound's handling requires careful procedures to ensure safety in laboratory environments, emphasizing the importance of proper laboratory practices.

In summary, N,N-dimethyl-2-[o-tolyl(phenyl)methoxy]ethanamine hydrochloride is not only a significant entity in pharmacology but also serves as an excellent example of the complexity and utility of chemical compounds. As scientists continue to explore its potential, this compound stands as a testament to the innovative spirit of modern chemistry.

Synonyms
Orphenadrine hydrochloride
341-69-5
Orphenadrine HCl
Mephenamin
Disipal
Mephenamine
Mebedrol
Mephenamin forte
Mefenamin hydrochloride
Orphenadrine (hydrochloride)
Mephenamin hydrochloride
Orfenadrin hydrochloride
Mephenamine hydrochloride
Brocadisipal
Orphenadrine (Chloride)
BF 5930
BG 5930
UNII-UBY910DUXH
UBY910DUXH
EINECS 206-435-4
NSC 82357
NSC-82357
Disipal hydrochloride
BS 5930
DTXSID5025815
2-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride
N,N-Dimethyl-2-(2-methylbenzhydryloxy)ethylamine hydrochloride
MLS000069427
DTXCID405815
CHEBI:60902
Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-, hydrochloride
beta-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride
SMR000058999
N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyloxy)ethylamine hydrochloride
Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride
ETHYLAMINE, N,N-DIMETHYL-2-((o-METHYL-alpha-PHENYLBENZYL)OXY)-, HYDROCHLORIDE
ORPHENADRINE HYDROCHLORIDE (MART.)
ORPHENADRINE HYDROCHLORIDE [MART.]
ORPHENADRINE HYDROCHLORIDE (EP IMPURITY)
ORPHENADRINE HYDROCHLORIDE [EP IMPURITY]
ORPHENADRINE HYDROCHLORIDE (EP MONOGRAPH)
ORPHENADRINE HYDROCHLORIDE [EP MONOGRAPH]
SR-01000002975
Brocasipal
Prestwick_663
Disipal (TN)
Orphenadrine Chloride
N,N-dimethyl-2-((2-methylphenyl)(phenyl)methoxy)ethanamine hydrochloride
N,N-dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine hydrochloride
Opera_ID_658
Orphenedrine hydrochloride
CAS-341-69-5
Hydrochloride, Orphenadrine
REGID_for_CID_9568
MLS001148572
MLS002548882
MLS006011645
ORPHENADIN HYDROCHLORIDE
SCHEMBL1235378
CHEMBL1201023
UQZKYYIKWZOKKD-UHFFFAOYSA-N
GLXC-10292
HMS1568P19
HY-B1126
NSC82357
o-Methyldiphenhydramine hydrochloride
Tox21_301927
Tox21_500884
MFCD00012480
s5664
AKOS024307520
dimethyl({2-[(2-methylphenyl)(phenyl)methoxy]ethyl})amine hydrochloride
N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine hydrochloride
WLN: 1N1&2OYR&R B1 &GH
CCG-220239
CCG-222188
CS-4723
LP00884
NC00465
(+-)-ORPHENADRINE HYDROCHLORIDE
NCGC00089814-04
NCGC00094204-01
NCGC00094204-02
NCGC00255176-01
NCGC00261569-01
LS-14663
ORPHENADRINE HYDROCHLORIDE [VANDF]
ORPHENADRINE HYDROCHLORIDE [WHO-DD]
DB-048578
EU-0100884
NS00079483
O0406
Orphenadrine hydrochloride, >=98.0% (AT)
WLN: 1N1 & 2OYR & R B1 & GH
D02599
O 3752
ORPHENADRINE HYDROCHLORIDE [ORANGE BOOK]
EN300-18532501
SR-01000002975-2
SR-01000002975-7
Q27129640
2-(DIMETHYLAMINO)ETHYL 2-METHYLBENZHYDRYL ETHER HYDROCHLORIDE
Ethylamine,N-dimethyl-2-[phenyl-(o-tolyl)methoxy]-, hydrochloride
N,N-Dimethyl-2-[(.alpha.-o-tolylbenzyl)oxy]ethylamine hydrochloride
N,N-Dimethyl-2-[.alpha.-(o-tolyl)benzyloxy]ethylamine hydrochloride
Ethanamine,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-, hydrochloride
Ethylamine,N-dimethyl-2-[.alpha.-(o-tolyl)benzyloxy]-, hydrochloride
N,N-Dimethyl-2-(o-methyl-.alpha.-phenylbenzyloxy)ethylamine hydrochloride
N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine;hydrochloride
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard
Ethylamine,N-dimethyl-2-[(o-methyl-.alpha.-phenylbenzyl)oxy]-, hydrochloride
N,N-DIMETHYL-2-((2-METHYLPHENYL)PHENYLMETHOXY)ETHANAMINE HYDROCHLORIDE
N,N-DIMETHYL-2-((O-METHYL-ALPHA-PHENYLBENZYL)OXY)ETHYLAMINE HYDROCHLORIDE
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard
206-435-4