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Flequinavir

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Identification
Molecular formula
C18H32F3N2
CAS number
161649-14-9
IUPAC name
N,N-dimethyl-3-[10-(trifluoromethyl)-3-azaspiro[5.5]undecan-3-yl]propan-1-amine
State
State

At room temperature, Flequinavir is primarily found in a solid state typically as crystalline or powdered form.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
394.00
Boiling point (Kelvin)
667.15
General information
Molecular weight
353.48g/mol
Molar mass
353.4800g/mol
Density
1.2852g/cm3
Appearence

N,N-dimethyl-3-[10-(trifluoromethyl)-3-azaspiro[5.5]undecan-3-yl]propan-1-amine appears as a white to off-white crystalline solid. It may also be formulated into a fine powder for various applications.

Comment on solubility

Solubility of N,N-dimethyl-3-[10-(trifluoromethyl)-3-azaspiro[5.5]undecan-3-yl]propan-1-amine

The solubility of N,N-dimethyl-3-[10-(trifluoromethyl)-3-azaspiro[5.5]undecan-3-yl]propan-1-amine can be determined by considering its structural features and functional groups. Here are some key aspects to take into account:

  • Polarity: The presence of the trifluoromethyl group suggests potential for strong dipole-dipole interactions, which can affect solubility in polar solvents.
  • Hydrophobic & Hydrophilic Balance: The spirocyclic structure may contribute to a degree of hydrophobicity, which can limit solubility in water but enhance compatibility with organic solvents.
  • Functional Groups: The amine group can participate in hydrogen bonding, potentially increasing solubility in polar solvents such as water and alcohols.

Overall, the compound is likely to exhibit moderate solubility in polar solvents due to its balance of hydrophilic amine functionality and hydrophobic spirocyclic structure. However, it may show limited solubility in nonpolar solvents. Testing in various solvents would provide more definitive insights into its solubility behavior.

Interesting facts

Interesting Facts about N,N-Dimethyl-3-[10-(trifluoromethyl)-3-azaspiro[5.5]undecan-3-yl]propan-1-amine

N,N-Dimethyl-3-[10-(trifluoromethyl)-3-azaspiro[5.5]undecan-3-yl]propan-1-amine is a fascinating compound with unique structural characteristics that make it a subject of significant interest in medicinal chemistry and pharmacology.

Structural Features

This compound features a complex spirocyclic structure, which is characterized by:

  • Azaspiro System: The inclusion of the azaspiro moiety adds to the compound's three-dimensional shape, which can impact its biological activity.
  • Trifluoromethyl Group: The presence of the trifluoromethyl substituent enhances the lipophilicity of the compound, potentially leading to increased membrane permeability.

Potential Applications

This molecule is part of a class of compounds known for their potential therapeutic effects, and researchers are particularly interested in:

  • Neuropharmacology: Compounds similar to this one may interact with neurotransmitter systems, offering potential routes for treating neurological disorders.
  • Anticancer Research: The unique structure might allow it to interfere with pathways involved in cancer cell proliferation.

Quote from the Field

As noted by a leading researcher in the field, “The design of compounds with intricate architectures like this one opens new avenues for targeted therapy, allowing for the possibility of selective action with lower side effects.”

Overall, N,N-dimethyl-3-[10-(trifluoromethyl)-3-azaspiro[5.5]undecan-3-yl]propan-1-amine exemplifies the exciting possibilities in drug design, showcasing how innovative structural modifications can lead to compounds with enhanced biological activity.

Synonyms
BRN 1642827
19755-97-6
N-(3-Dimethylaminopropyl)-8-trifluoromethyl-3-azaspiro(5.5)undecane
3-AZASPIRO(5.5)UNDECANE, 3-(3-(DIMETHYLAMINO)PROPYL)-8-(TRIFLUOROMETHYL)-
5-20-04-00449 (Beilstein Handbook Reference)
RefChem:276792
DTXSID70941512
N,N-Dimethyl-3-[8-(trifluoromethyl)-3-azaspiro[5.5]undecan-3-yl]propan-1-amine