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Doxepin

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Identification
Molecular formula
C19H21NO
CAS number
1668-19-5
IUPAC name
N,N-dimethyl-3-(2-methyl-5,5-dioxo-6H-benzo[c][1]benzothiepin-11-ylidene)propan-1-amine
State
State

At room temperature, doxepin is typically in a solid state. It is commonly encountered as a hydrochloride salt when used in pharmaceutical formulations, which also remains solid at room conditions.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
511.30
Boiling point (Kelvin)
784.45
General information
Molecular weight
279.38g/mol
Molar mass
279.3820g/mol
Density
1.2000g/cm3
Appearence

Doxepin typically appears as a white to off-white crystalline powder. It is odorless and may have a bitter taste. In some cases, doxepin hydrochloride (the salt form) is used and it may exhibit a similar appearance.

Comment on solubility

Solubility of N,N-dimethyl-3-(2-methyl-5,5-dioxo-6H-benzo[c][1]benzothiepin-11-ylidene)propan-1-amine

The solubility of N,N-dimethyl-3-(2-methyl-5,5-dioxo-6H-benzo[c][1]benzothiepin-11-ylidene)propan-1-amine is a multifaceted topic that incorporates various factors affecting its dissolution in different solvents. As a complex organic molecule, its solubility can be affected by:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents like water.
  • Hydrophobic regions: Such regions may lead to reduced solubility in aqueous environments, promoting stronger interactions with non-polar solvents.
  • Temperature: Increased temperatures often improve solubility, allowing more of the compound to dissolve in a solvent.
  • pH level: For compounds with amine functionalities, changes in pH can either protonate or deprotonate the molecule, significantly influencing solubility.

In practice, this compound has shown varying levels of solubility in different solvents:

  • Soluble in organic solvents: Compounds like ethanol and DMSO often show good solubility due to favorable interactions.
  • Limited solubility in water: Due to the large hydrophobic components, water solubility may be quite limited.

Understanding these solubility characteristics is vital for applications in pharmaceuticals and materials science, where solubility can dictate formulation success or compound efficacy. As highlighted by various studies, "the solubility profile often defines the bioavailability of the compound," emphasizing its significance in practical applications.

Interesting facts

Interesting Facts about N,N-Dimethyl-3-(2-methyl-5,5-dioxo-6H-benzo[c][1]benzothiepin-11-ylidene)propan-1-amine

N,N-Dimethyl-3-(2-methyl-5,5-dioxo-6H-benzo[c][1]benzothiepin-11-ylidene)propan-1-amine, often referred to as a complex organic molecule, primarily draws interest due to its unique structure and potential applications. Here are some fascinating aspects:

  • Structural Complexity: This compound is characterized by a diverse arrangement of atoms, featuring both amine and diketone functional groups, which makes it particularly appealing to chemists studying structure-activity relationships.
  • Bioactivity: Studies suggest that compounds similar to this one may exhibit interesting biological activities, initiating research into their potential use in pharmaceuticals as anti-inflammatory or anti-cancer agents.
  • Synthetic Pathways: The synthesis of this molecule can provide insight into multi-step reaction pathways, allowing chemistry students to explore reaction mechanisms that link simple functional groups into more complex architectures.
  • Interdisciplinary Connections: This compound may bridge the gap between organic chemistry, medicinal chemistry, and even materials science, illustrating the importance of interdisciplinary approaches in modern scientific research.

This molecule exemplifies the intricate nature of organic compounds that can lead to essential discoveries. As noted by one prominent chemist, “The beauty of chemistry lies in its ability to combine simple building blocks into complex structures,” which accurately reflects the essence of compounds like N,N-dimethyl-3-(2-methyl-5,5-dioxo-6H-benzo[c][1]benzothiepin-11-ylidene)propan-1-amine.

Overall, this compound serves as an exciting subject for further exploration in both academic and practical applications. With ongoing research, who knows what additional properties we may uncover?