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Memantine

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Identification
Molecular formula
C12H21NO
CAS number
19982-08-2
IUPAC name
N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine oxide
State
State

At room temperature, memantine is typically encountered as a crystalline powder in a solid state. It is handled in this form for most pharmaceutical applications.

Melting point (Celsius)
292.00
Melting point (Kelvin)
565.15
Boiling point (Celsius)
322.30
Boiling point (Kelvin)
595.45
General information
Molecular weight
215.34g/mol
Molar mass
215.3350g/mol
Density
1.1630g/cm3
Appearence

Memantine is a white to off-white, crystalline substance. It is typically found in the form of a hydrochloride salt, which is more stable and easier to handle than the free base form. It is not colored and has no distinctive odor.

Comment on solubility

Solubility of N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine oxide

The solubility of the compound N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine oxide can be quite intriguing due to its complex structure. Understanding its solubility involves considering several critical factors:

  • Molecular Structure: The presence of the tricyclic structure may hinder solubility in polar solvents, while the amine oxide can enhance solubility in certain organic solvents.
  • Polarity: The polarity of the molecule plays a significant role in determining solubility; generally, non-polar compounds dissolve well in non-polar solvents.
  • Temperature: Like many chemical compounds, solubility may increase with temperature, making it essential to conduct solubility tests at varying temperatures.
  • Solvent Compatibility: Testing this compound in a range of solvents, such as water, ethanol, and chloroform, could yield different results based on the interactions involved.

As a general guideline, “like dissolves like”, meaning that polar compounds tend to dissolve in polar solvents and non-polar compounds prefer non-polar environments. The intricate balance of interactions expected from this compound suggests that further investigation into its solubility in various environments is warranted.

In conclusion, the solubility characteristics of N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine oxide are likely complex, warranting detailed experimental studies to elucidate its behavior in different solvents.

Interesting facts

Interesting Facts About N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine oxide

N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine oxide is an intriguing compound that showcases the fascinating interplay between structure and function in chemical compounds. Here are some notable aspects of this compound:

  • Complex Structure: The unique tricyclic framework in this compound indicates a high level of molecular complexity. This structure contributes to its potential reactivity and interaction with biological systems.
  • Versatile Applications: Due to its distinctive features, compounds like this one may have applications in medicinal chemistry, particularly for the development of new pharmaceuticals targeting complex diseases.
  • Oxide Group Significance: The presence of the amine oxide functional group can greatly enhance the reactivity of the molecule, enabling it to act as a better ligand or catalyst in various chemical reactions.
  • Natural Product Inspiration: The inspiration for compounds like this often comes from natural products. These natural structures frequently serve as models for synthetic chemists looking to create new compounds with valuable properties.
  • Research Frontiers: Ongoing research delves into the synthesis, properties, and potential applications of complex amine oxides, making this a vibrant area of study for chemists today.

As we delve deeper into the realm of organic chemistry, compounds like N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine oxide exemplify the intricate beauty of molecular design. Each compound holds secrets to be uncovered, providing endless opportunities for innovation and discovery in the field.

Synonyms
Amitriptylinoxide
Amitriptyline N-oxide
4317-14-0
Ambivalon
amitriptyline-n-oxide
Amitriptilinoxido
Amitriptylinoxyde
amitriptyline oxide
Amitriptylinoxide [INN]
Amitriptylinoxidum
Amioxid-neuraxpharm
Amitriptylinoxidum [INN-Latin]
Amitriptylinoxyde [INN-French]
Amitriptilinoxido [INN-Spanish]
UNII-TYR2U59WMA
BRN 2385442
Amitriptylinoxide (INN)
J9.621K
AMITRYPTYLINE-N-OXIDE
AMITRIPTYLINOXIDE [MI]
1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-N-oxide
DTXSID50195758
AMITRIPTYLINOXIDE [WHO-DD]
10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta5,gamma-propylamine-N-oxide
3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin N-oxid
5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N,N-dimethyl-N-oxide
Amitriptylinoxidum (INN-Latin)
Amitriptylinoxyde (INN-French)
Amitriptilinoxido (INN-Spanish)
NORTRIPTYLINE HYDROCHLORIDE IMPURITY J [EP IMPURITY]
3-(10,11-Dihydro-5H-dibenzo-[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-oxide
5H-Dibenzo(a,d)cycloheptene-.delta.5,.gamma.-propylamine, 10,11-dihydro-N,N-dimethyl-N-oxide
NORTRIPTYLINE HYDROCHLORIDE IMPURITY J (EP IMPURITY)
3-(10,11-Dihydro-5H-dibenzo-(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-oxide
N,N-dimethyl-3-(tricyclo(9.4.0.0^(3,8))pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene)propanamine oxide
N,N-dimethyl-3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propanamine oxide
DTXCID90118249
5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-N-oxide
610-112-7
zpmkqfoginqdam-uhfffaoysa-n
Equilibrin
TYR2U59WMA
10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine N-oxide
N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine oxide
NSC176555
Amitriptylinoxid
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-Oxide; 10,11-Dihydro-N,N-dimethyl-5H-Dibenzo[a,d]cycloheptene-?5,?-propylamine N-Oxide; Amitriptyline Oxide; Amitriptylinoxide; Equilibrin
Amitryptiline-N-oxide
CHEMBL627
NCIStruc1_001927
NCIStruc2_001301
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-oxide
SCHEMBL54518
CHEBI:135224
BDBM112778
CCG-37141
NCGC00014514
NCI176555
AKOS040746566
DB13114
10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta5,gamma-propylamine N-oxide
NCGC00014514-02
NCGC00097618-01
DA-70809
FA178736
NCI60_001463
US8629135, SW-03
HY-107032
NS00001882
D07449
Q472476
(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl)(hydroxy)dimethyl-5-azane
3-(5,6-dihydrodibenzo[[?],[?]][7]annulen-11-ylidene)-N,N-dimethyl-propan-1-amine oxide
(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl)(hydroxy)dimethyl-.lambda.~5~-azane
10,11-Dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-.DELTA.5,.gamma.-propylamine N-oxide