Flibanserin | Solubility of Things

Identification

Molecular formula

C₂₀H₂₁N₅O₂

CAS number

167933-07-5

IUPAC name

N,N-dimethyl-3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propan-1-amine

State

Flibanserin is in a solid state at room temperature.

Melting point (Celsius)

225.00

Melting point (Kelvin)

498.15

Boiling point (Celsius)

700.00

Boiling point (Kelvin)

973.15

General information

Molecular weight

390.45g/mol

Molar mass

390.4500g/mol

Density

1.3658g/cm³

Appearence

Flibanserin is a white to off-white crystalline powder.

Comment on solubility

Solubility of N,N-dimethyl-3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propan-1-amine

The solubility of N,N-dimethyl-3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propan-1-amine can be influenced by a variety of factors, making it a subject of interest in both research and application contexts. Analyzing its solubility properties yields several key points to consider:

Polar vs Non-polar Characteristics: The compound contains both polar and non-polar segments, resulting in variable solubility in different solvents.
Solvent Interaction: It may dissolve readily in organic solvents such as ethanol or DMSO, but show limited solubility in water due to its complex structure.
pH Sensitivity: Changes in pH can significantly impact the ionization of the amine group, consequently affecting its solubility.
Temperature Relevance: As with many compounds, solubility can increase with temperature, leading to potential variations in solubility profiles at different experimental conditions.

To truly understand the solubility potential of this compound, one must conduct empirical measurements under controlled conditions and take into account the various interacting factors that could affect solubility behavior.

Interesting facts

Interesting Facts about N,N-Dimethyl-3-[5-Nitro-2-[2-(1-Piperidyl)Ethyl]Benzimidazol-1-Yl]Propan-1-Amine

N,N-Dimethyl-3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propan-1-amine is a fascinating chemical compound with noteworthy attributes. Here are some interesting aspects:

Mechanism of Action: This compound is often studied for its potential use in pharmacology, particularly as an *antimicrobial agent*. Its structure allows it to interact with biological systems effectively.
Design and Synthesis: The intricate synthesis involves clever organic chemistry techniques that highlight the importance of *ligand design*. Chemists often explore how slight modifications can significantly influence activity.
Broad Spectrum Activity: Due to the presence of both a nitro group and a benzimidazole ring, the compound may exhibit *broad-spectrum antimicrobial properties*, making it a subject of interest in developing new antibiotics.
Piperidine Influence: The piperidine moiety in the structure is known for enhancing *lipophilicity*, which can help in crossing cell membranes and enhancing bioavailability.
Research Applications: Studies on this compound may lead to a better understanding of *drug resistance patterns*, which is a critical issue in infectious disease treatment.

In conclusion, N,N-dimethyl-3-[5-nitro-2-[2-(1-piperidyl)ethyl]benzimidazol-1-yl]propan-1-amine demonstrates how chemical structure is intricately related to biological activity. As researchers continue to study this compound, it could pave the way for new therapeutic agents in the fight against resistant pathogens.