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Amlexanox

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Identification
Molecular formula
C16H14N2O4S
CAS number
68302-57-8
IUPAC name
N,N-dimethyl-3-(6-methyl-5,5-dioxo-benzo[c][1,2,5]benzothiadiazepin-11-yl)propan-1-amine
State
State

At room temperature, amlexanox is in a solid state, typically in the form of a crystalline powder.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
485.00
Boiling point (Kelvin)
758.15
General information
Molecular weight
378.46g/mol
Molar mass
378.4600g/mol
Density
1.4853g/cm3
Appearence

Amlexanox appears as a white to pale yellow powder. It is generally considered to be odorless.

Comment on solubility

Solubility of N,N-dimethyl-3-(6-methyl-5,5-dioxo-benzo[c][1,2,5]benzothiadiazepin-11-yl)propan-1-amine

The solubility of N,N-dimethyl-3-(6-methyl-5,5-dioxo-benzo[c][1,2,5]benzothiadiazepin-11-yl)propan-1-amine is influenced by its complex structure. Understanding its solubility characteristics can be crucial for its application in various fields. Here are some key points regarding its solubility:

  • Polar vs. Nonpolar: The compound contains both polar and nonpolar groups, leading to heterogeneous solubility behavior.
  • Solvent Dependency: It may exhibit better solubility in polar aprotic solvents, such as DMSO or DMF, due to its amine functional group.
  • Temperature Effects: Solubility can increase with elevated temperatures, which is typical for many organic compounds.
  • pH Influence: Changes in pH can alter the ionization of the amine, potentially enhancing solubility in aqueous solutions.

In conclusion, assessing the solubility of this compound is essential for optimizing its usage in chemical reactions and formulations. As a general guideline, conducting empirical solubility tests under various conditions is recommended for a definitive understanding.

Interesting facts

Interesting Facts about N,N-Dimethyl-3-(6-methyl-5,5-dioxo-benzo<c><1,2,5>benzothiadiazepin-11-yl)propan-1-amine

N,N-Dimethyl-3-(6-methyl-5,5-dioxo-benzo1,2,5benzothiadiazepin-11-yl)propan-1-amine is a fascinating chemical compound that draws attention from both synthetic chemists and pharmacologists. Here are some remarkable highlights about this compound:

  • Structure and Complexity: The compound features a unique structure characterized by a thiadiazepine core enriched with multiple functional groups, making it an interesting subject for studies in medicinal chemistry.
  • Pharmacological Potential: Compounds of this class often exhibit a wide range of biological activities. Investigations have suggested that derivatives related to benzothiadiazepines possess anxiolytic, antidepressant, and neuroprotective effects.
  • Dimethylamino Group: The presence of the N,N-dimethylamino moiety often enhances lipid solubility, which can improve the compound's ability to cross the blood-brain barrier, potentially increasing its therapeutic efficacy.
  • Importance in Drug Design: Understanding the structure-activity relationships (SAR) of such compounds is crucial. Scientists utilize these insights to design more effective and selective drugs.
  • Research and Development: Ongoing research is exploring the mechanisms of action of this compound, aiming to unlock new avenues for treatment in various neurological disorders.

This compound, layered with complexity and potential, serves as an excellent example of how chemical scaffolds influence biological activity. As the exploration of such compounds continues, the hope for novel therapeutics remains high.

Synonyms
Dibenzo(1,2,5)thiadiazepine, 6,11-dihydro-11-(3-(dimethylamino)propyl)-6-methyl-, 5,5-dioxide
7200-23-9
DTXSID40222284
11-(3-(Dimethylamino)propyl)-6-methyl-6,11-dihydrodibenzo(1,2,5)thiadiazepine 5,5-dioxide
6-Methyl 11 (3-dimethylaminopropyl)dibenzo(c.f)(1,2,5)thiadiazepine 5,5-dioxyde [French]
6-Methyl 11 (3-dimethylaminopropyl)dibenzo(c.f)(1,2,5)thiadiazepine 5,5-dioxyde
DTXCID40144775
CHEMBL281528
SCHEMBL9768806