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Amitriptyline

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Identification
Molecular formula
C20H23N1S1
CAS number
50-48-6
IUPAC name
N,N-dimethyl-3-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)propan-1-amine
State
State

Amitriptyline is a crystalline solid at room temperature. It is typically encountered in the form of medicinal tablets or capsules, designed for oral administration.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
462.90
Boiling point (Kelvin)
736.05
General information
Molecular weight
277.44g/mol
Molar mass
277.4360g/mol
Density
1.1079g/cm3
Appearence

Amitriptyline is typically a white or slightly yellow crystalline powder. It is usually odorless and bitter to taste. This medication is often encountered in the form of tablets or capsules when used pharmaceutically.

Comment on solubility

Solubility of N,N-dimethyl-3-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)propan-1-amine

The solubility characteristics of N,N-dimethyl-3-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)propan-1-amine are intriguing due to its complex structure and the presence of multiple functional groups. Generally, the solubility of a compound can be influenced by various factors, including:

  • Polarity: Compounds with polar functional groups tend to be more soluble in polar solvents like water, while non-polar segments favor solubility in organic solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds enhances solubility in water. If this compound exhibits such functionalities, it may dissolve better in aqueous environments.
  • Alkyl Chain Length: The presence of longer alkyl chains can decrease solubility in polar solvents due to increased hydrophobicity.
  • Conformation: The specific three-dimensional arrangement adopted by the cyclic structures in the compound may also play a critical role in solubility.

While detailed solubility data may not be readily available for this specific compound, experimentation can provide valuable insights. As a general rule of thumb, when assessing solubility:

  1. Start with small-scale tests in both polar and non-polar solvents.
  2. Observe the temperature dependence of solubility, as it can vary significantly.
  3. Consider the use of co-solvents to enhance solubility if initial tests show limited dissolution.

In conclusion, the solubility of N,N-dimethyl-3-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)propan-1-amine is a multifaceted property determined by its unique characteristics. Understanding these factors will be crucial for applications in chemical synthesis and formulation.

Interesting facts

Interesting Facts about N,N-Dimethyl-3-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)propan-1-amine

N,N-dimethyl-3-(7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-ylsulfanyl)propan-1-amine is a fascinating compound that draws attention for its unique structure and potential applications. Here are some intriguing details:

  • Complex Structure: This compound features a complex bicyclic structure that includes a tetrahydroquinoline framework, which is known for its structural diversity and biological activity.
  • Biological Relevance: Compounds related to this class often exhibit interesting pharmacological properties, with **antidepressant** and **anxiolytic** effects being a notable area of research.
  • Thioether Group: The presence of the sulfanyl (thioether) group is significant, as it can influence the compound's reactivity and biological interactions, potentially increasing its lipophilicity.
  • Research Potential: The compound's structure allows chemists to explore a wide range of modifications, which can lead to the discovery of new derivatives with enhanced biological activity.
  • Medicinal Chemistry: It serves as a potential lead compound in drug discovery, providing insights into structure-activity relationships that can be exploited in medicinal chemistry.

As a student or researcher, one might find it rewarding to dive deeper into this compound’s synthetic pathways, biological mechanisms, and potential therapeutic uses. The intersection of organic chemistry and pharmacology is where compounds like this can lead to groundbreaking discoveries in medicine and health.

In a quote reflecting the spirit of scientific exploration, "Chemistry is the ability to take the elements of nature and transform them into something beautiful and useful." This compound epitomizes that transformative potential.