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Chlorpromazine hydrochloride

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Identification
Molecular formula
C17H19ClN2S · HCl
CAS number
69-09-0
IUPAC name
N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine;hydrochloride
State
State

Chlorpromazine hydrochloride is typically found in a solid state at room temperature. As a stable compound, it can be stored under normal conditions without significant degradation, though it should be protected from light and moisture.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.00
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.00
General information
Molecular weight
355.33g/mol
Molar mass
355.3340g/mol
Density
1.3620g/cm3
Appearence

Chlorpromazine hydrochloride is a white to off-white crystalline powder. It is odorless or has a faint odor. The compound is highly hygroscopic, meaning it can absorb moisture from the environment. In its solution form, it is often clear and colorless.

Comment on solubility

Solubility of N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine; hydrochloride

N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine; hydrochloride (C17H19ClN2S · HCl) exhibits unique solubility characteristics due to its molecular structure. Understanding its solubility is essential for applications in pharmaceuticals, as it directly affects bioavailability and therapeutic efficacy.

Solubility Characteristics:

  • Soluble in Water: The presence of the hydrochloride salt significantly enhances its solubility in aqueous solutions, making it suitable for formulations requiring water solubility.
  • Organic Polar Solvents: N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine shows moderate solubility in polar organic solvents, such as ethanol and methanol.
  • Low Solubility in Non-Polar Solvents: It is generally insoluble in non-polar solvents such as hexane or chloroform, which limits its use in certain industrial applications.

It is important to note that the solubility can be influenced by factors like pH, temperature, and the presence of other ions or compounds in the solution. Thus, accurate solubility assessments are essential for effective formulation development.

As a general rule, "the more polar the solvent, the better the solubility for polar and ionic compounds." This principle is particularly applicable in the case of this compound, where its ionic nature enhances solubility in polar environments.


Interesting facts

N,N-Dimethyl-3-phenothiazin-10-yl-propan-1-amine Hydrochloride

N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine hydrochloride is a fascinating chemical compound known for its role in various applications, particularly in the field of medicinal chemistry. Here are some intriguing facts about this compound:

  • Pharmaceutical Significance: This compound is often investigated for its potential therapeutic properties. It is a derivative of phenothiazine, a class of compounds that has been used extensively in drugs for treating psychiatric conditions.
  • Psychoactive Properties: Phenothiazines, including this compound, are known for their antipsychotic effects, which can offer relief for patients with disorders such as schizophrenia and severe anxiety.
  • Structure and Function: The unique structure of N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine includes a phenothiazine ring system, contributing to its biological activity and ability to interact with neurotransmitter receptors.
  • Research Frontiers: This compound is actively studied within pharmacology and medicinal chemistry, with research focusing on optimizing its properties to enhance efficacy and reduce side effects.
  • Safety Considerations: While compounds like this can offer medical benefits, they also require careful evaluation regarding toxicity and potential adverse effects, emphasizing the importance of thorough scientific research.

In the words of a renowned chemist, "Every compound tells a story through its interaction with biological systems." Thus, understanding the properties and effects of compounds like N,N-dimethyl-3-phenothiazin-10-yl-propan-1-amine hydrochloride is essential for advancing therapeutic strategies in modern medicine.

Synonyms
PROMAZINE HYDROCHLORIDE
53-60-1
Promazine Hcl
Sparine
Starazin
Talofen
Promazine (hydrochloride)
Promazine monohydrochloride
Chlorowodorek promazyny
RP 4560
N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride
EINECS 200-179-7
UNII-U16EOR79U4
NSC 17468
NSC-17468
U16EOR79U4
DTXSID4046949
AI3-28022
10H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride
N-(3-(Dimethylamino)propyl)phenothiazine hydrochloride
10-(3-(Dimethylamino)propyl)phenothiazine hydrochloride
Promazine hydrochloride (USP)
Promazine hydrochloride [USP]
MLS000069671
CHEBI:8460
10-(3-(Dimethylamino)propyl)phenothiazine monohydrochloride
10-(gamma-Dimethylamino-n-propyl)phenothiazine hydrochloride
Phenothiazine, 10-(3-(dimethylamino)propyl)-, hydrochloride
DTXCID2026949
NSC17468
SMR000058499
Phenothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride
10-(3-Dimethylaminopropyl)phenothiazine hydrochloride
PROMAZINE HYDROCHLORIDE (MART.)
PROMAZINE HYDROCHLORIDE [MART.]
PROMAZINE HYDROCHLORIDE (USP-RS)
PROMAZINE HYDROCHLORIDE [USP-RS]
PROMAZINE HYDROCHLORIDE (EP MONOGRAPH)
PROMAZINE HYDROCHLORIDE [EP MONOGRAPH]
Chlorowodorek promazyny [Polish]
PROMAZINE HYDROCHLORIDE (USP MONOGRAPH)
PROMAZINE HYDROCHLORIDE [USP MONOGRAPH]
CAS-53-60-1
SR-01000000228
NCGC00015829-02
N-[3-(Dimethylamino)propyl]phenothiazine hydrochloride
10-(3-[Dimethylamino]propyl)phenothiazine hydrochloride
10-[3-(Dimethylamino)propyl]phenothiazine hydrochloride
PROMAZINEHYDROCHLORIDE
10-[3-(Dimethylamino)propyl]phenothiazine monohydrochloride
Esparinal
Verofen
SR-01000000228-4
Promazine chloride
Promazine Granules
Prestwick_974
Sparine (TN)
Tranquazine Injection
10H-Phenothiazine-10-propanamine, N,N-dimethyl-,monohydrochloride
Opera_ID_41
Hydrochloride, Promazine
Promazine HCl Injectable
Propazin (pharmaceutical)
REGID_for_CID_5887
MLS001148436
MLS002222285
SCHEMBL123418
SPECTRUM1500509
CHEMBL1200469
JIVSXRLRGOICGA-UHFFFAOYSA-N
HMS1570K07
HMS1920L14
Pharmakon1600-01500509
HY-B1225
PROMAZINE HYDROCHLORIDE [MI]
Tox21_110235
Tox21_500961
10-H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride
CCG-40284
MFCD00058535
NSC757300
s5428
AKOS015964305
Tox21_110235_1
CS-4873
KS-1384
LP00961
NSC-757300
PROMAZINE HYDROCHLORIDE [VANDF]
PROMAZINE HYDROCHLORIDE [WHO-DD]
NCGC00015829-12
NCGC00094262-01
NCGC00094262-02
NCGC00094262-03
NCGC00094262-04
NCGC00094262-05
NCGC00261646-01
AC-18101
DA-66892
PROMAZINE HYDROCHLORIDE [GREEN BOOK]
EU-0100961
NS00078987
PROMAZINE HYDROCHLORIDE [ORANGE BOOK]
WLN: T C666 BN ISJ B3N1&1 &GH
D00797
D78322
EN300-127034
P 6656
SR-01000000228-2
SR-01000000228-8
Q27108085
Z1592690521
Promazine hydrochloride, VETRANAL(TM), analytical standard
10-(.gamma.-Dimethylamino-n-propyl)phenothiazine hydrochloride
dimethyl[3-(10H-phenothiazin-10-yl)propyl]amine hydrochloride
Promazine Hydrochloride 1.0 mg/ml in Methanol (as free base)
10H-Phenothiazine-10-propanamine, N,N-dimethyl-, hydrochloride (1:1)
Promazine hydrochloride, European Pharmacopoeia (EP) Reference Standard
Promazine hydrochloride, United States Pharmacopeia (USP) Reference Standard
200-179-7