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Pretomanid

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Identification
Molecular formula
C14H12N4O3S
CAS number
187235-37-6
IUPAC name
N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine
State
State

At room temperature, pretomanid is typically found in a solid state, often as a crystalline powder. This makes it relatively easy to handle and store in standard conditions.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
515.20
Boiling point (Kelvin)
788.35
General information
Molecular weight
359.46g/mol
Molar mass
359.4620g/mol
Density
1.4600g/cm3
Appearence

Pretomanid usually comes in the form of a white to pale yellow crystalline solid or powder. It is relatively stable but may exhibit some variance in color depending on impurities or the method of synthesis used.

Comment on solubility

Solubility of N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine

The solubility of N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine is influenced by several factors due to its complex structure. Here are some key points regarding its solubility:

  • Polarity: The presence of both polar and nonpolar functional groups within the compound can create challenges for solubility in typical solvents.
  • Solvent Choice: It is generally observed that the compound is more soluble in organic solvents such as dimethyl sulfoxide (DMSO), ethanol, and acetone compared to water.
  • Temperature: Increasing temperature often enhances solubility, allowing for a greater dissolution of the compound in organic media.
  • Interactions: Hydrogen bonding ability can facilitate solubility in polar solvents, but steric hindrance from its bulky structure might offset this effect.

Overall, while the solubility of this compound can be characterized as limited in aqueous environments, it shows more favorable interactions with organic solvents. Understanding these properties is crucial for applications in pharmaceuticals and materials science.

Interesting facts

Interesting Facts about N,N-Dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine

This fascinating compound, known as N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine, is notable within the realm of synthetic chemistry due to its complex structure and potential applications. Here are some insightful points about this compound:

  • Structural Complexity: This compound features a unique bicyclic structure that combines both benzothiazine and pyridine moieties, creating an intriguing molecular architecture that can influence its reactivity and interactions.
  • Biological Relevance: Compounds with similar structures are often researched for their biological activity. This particular class has been investigated for its potential antitumor and antimicrobial properties, which makes it a subject of interest in medicinal chemistry.
  • Research Potential: Due to its structural characteristics, N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine is anticipated to exhibit unique pharmacological effects that can lead to the development of novel therapeutic agents.
  • Substituted Amine Importance: The dimethylamine group in its structure is significant for enhancing solubility and the ability of the compound to cross biological membranes, thus playing a crucial role in its pharmacokinetic profile.

In summary, the intriguing molecular design and potential applications of N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine position it as a compound of interest in research circles. As one researcher aptly noted, "the journey of discovery in chemistry is often filled with surprises and remarkable compounds that hold the key to future innovations." This compound may very well be one of those keys.

Synonyms
Prothipendyl
Dominal
303-69-5
Largophren
Timoval
Timovan
Tolnate
Tumovan
Protipendilo
Phrenotropin
Prothipendylum
Prothipendyl [INN:BAN]
Prothipendylum [INN-Latin]
Protipendilo [INN-Spanish]
LG 206
MH 05101
UNII-5O6VWA87VA
D 206
5O6VWA87VA
Azacon (Salt/Mix)
BRN 0259865
Prothipendyl (INN)
AY 56031
Dimethylamino-n-propyl-thiophenylpyridylamine
10-(3-Dimethylaminopropyl)-1-azaphenothiazin
PROTHIPENDYL [MI]
PROTHIPENDYL [INN]
10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-
PROTHIPENDYL [WHO-DD]
10-(3-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazin
DTXSID50184389
EC 608-469-9
10H-Pyrido(3,2-b)(1,4)benzothiazine-10-propanamine, N,N-dimethyl-
4-27-00-07169 (Beilstein Handbook Reference)
10H-Pyrido[3,2-b][1,4]benzothiazine-10-propanamine, N,N-dimethyl-
Prothipendylum (INN-Latin)
Protipendilo (INN-Spanish)
10-(3-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazine
10H-Pyrido[3,2-b][1,4]benzothiazine, 10-[3-(dimethylamino)propyl]-
dimethyl(3-(9-thia-2,4-diazatricyclo(8.4.0.0^(3,8))tetradeca-1(14),3(8),4,6,10,12-hexaen-2-yl)propyl)amine
dimethyl(3-{9-thia-2,4-diazatricyclo[8.4.0.0^{3,8}]tetradeca-1(14),3(8),4,6,10,12-hexaen-2-yl}propyl)amine
DTXCID10106880
N05AX07
608-469-9
dominal (tn)
jttaupumolrvra-uhfffaoysa-n
N,N-Dimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-propanamine
N,N-DIMETHYL-10H-PYRIDO(3,2-B)(1,4)BENZOTHIAZINE-10-PROPANAMINE
Oprea1_108771
SCHEMBL145059
CHEMBL2111030
CHEBI:135182
N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-1-amine
AKOS040753637
DB12958
NS00006152
D07313
Q903551
N,N-Dimethyl-3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)-1-propanamine #