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Pretomanid hydrochloride

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Identification
Molecular formula
C14H18ClN3OS
CAS number
1256026-88-6
IUPAC name
N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine;hydrochloride
State
State
The compound is in a solid state at room temperature.
Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
363.89g/mol
Molar mass
363.8880g/mol
Density
1.3706g/cm3
Appearence

The compound appears as a white to slightly off-white crystalline powder.

Comment on solubility

Solubility Insights of N,N-Dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine; hydrochloride

N,N-Dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine; hydrochloride is an interesting compound when it comes to solubility. Here are some key points to consider:

  • Water Solubility: As a hydrochloride salt, this compound is generally more soluble in water compared to its non-salt form. This is due to the ionization of the amine group, allowing for better interactions with water molecules.
  • Organic Solvents: The compound may show varying degrees of solubility in organic solvents. The presence of the benzothiazin group can contribute to different solvation behaviors. Common solvents to consider might include:
    • Acetone
    • DMSO (Dimethyl sulfoxide)
    • Ethyl acetate
  • pH Influence: Solubility can change with pH. The basicity of the amine group can result in different solubility profiles. For example:
    • In acidic conditions, enhanced solubility is expected.
    • In neutral or basic conditions, the solubility may decrease as the compound might revert to its non-ionized form.
  • Temperature Effects: Temperature often plays a crucial role in solubility. Higher temperatures tend to increase solubility, making laboratory applications more feasible.

An understanding of these solubility characteristics is essential for the effective utilization of N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine; hydrochloride in various chemical and pharmaceutical applications. Careful consideration of the solvent choice, temperature, and pH can optimize its performance in practical scenarios.

Interesting facts

Interesting Facts about N,N-Dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine; Hydrochloride

N,N-Dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine; hydrochloride is a fascinating compound in the world of medicinal chemistry, known for its diverse biological activities. Here are some intriguing facets about this compound:

  • Antimicrobial Potential: Research has indicated that various benzothiazine derivatives exhibit antimicrobial properties, making them potential candidates for pharmaceutical applications in treating infections.
  • Psychotropic Properties: Some related compounds are studied for their effects on the central nervous system, and this compound may share such properties worth exploring.
  • Synthesis of Complexity: Its synthetic route often involves complex organic reactions, showcasing the ingenuity required in modern synthetic chemistry and the intricate relationships between structure and function.
  • Potential in Cancer Treatment: Certain analogs have been shown to possess anticancer activity, emphasizing the importance of heterocyclic compounds in drug discovery.
  • Multi-functional Uses: The versatility of this compound could lead to applications beyond medicinal uses, including potential roles in agrochemicals or as dye precursors.

As a key to unlocking future pharmacological advancements, N,N-Dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-yl-propan-1-amine; hydrochloride embodies the continual exploration and discovery within the realm of chemical compounds. Each study and synthesis holds the promise of new breakthroughs in therapeutic contexts.

Synonyms
PROTHIPENDYL HYDROCHLORIDE
1225-65-6
Azacon
Dominal hydrochloride
Prothipendyl HCl
Dominal forte
EINECS 214-958-4
Dominal (TN)
AY-56031
UNII-7610629RVH
7610629RVH
10-(3-Dimethylaminopropyl)-1-azaphenothiazine hydrochloride
D-206
DTXSID10153632
((4-Dimethylaminopropylpyrido (3,2b) benzothiazine)) hydrochloride
N,N-Dimethyl-10H-pyrido(3,2-b)(1,4)benzothiazine-10-propanamine, monohydrochloride
PROTHIPENDYL HYDROCHLORIDE [MI]
ANHYDROUS PROTHIPENDYL HYDROCHLORIDE
PROTHIPENDYL HYDROCHLORIDE [WHO-DD]
10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride
ANHYDROUS PROTHIPENDYL HYDROCHLORIDE [MART.]
ANHYDROUS PROTHIPENDYL HYDROCHLORIDE (MART.)
DTXCID5076123
214-958-4
dominal
(dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride
Prothipendyl (hydrochloride)
N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-1-amine;hydrochloride
(Dimethyl)(10H-pyrido(3,2-b)(1,4)benzothiazine-10-propyl)ammonium chloride
Prothipendyl Monohydrochloride
10H-Pyrido[3,2-b][1,4]benzothiazine, 10-(3-dimethylaminopropyl)-, hydrochloride (6CI); 10H-Pyrido[3,2-b][1,4]benzothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride (9CI); 10H-Pyrido[3,2-b][1,4]benzothiazine-10-propanamine, N,N-dimethyl-, hydrochloride (1:1); Prothipendyl Hydrochloride
CHEMBL2107124
CQJSAKJMCVSEGU-UHFFFAOYSA-N
AKOS025149619
FP27245
HY-116780A
DA-69149
CS-0644106
D08446
Q27266429
Pyridylamine, n-(3-dimethylaminopropyl)thiophenyl-, hydrochloride
N,N-Dimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-propanamine hydrochloride;AY 56031;Azacon