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Dimethylformamide

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Identification
Molecular formula
C3H7NO
CAS number
68-12-2
IUPAC name
N,N-dimethylformamide
State
State

At room temperature, dimethylformamide is in a liquid state. It remains clear and stable under normal conditions, contributing to its widespread use as a solvent in industrial and laboratory settings.

Melting point (Celsius)
-61.00
Melting point (Kelvin)
212.15
Boiling point (Celsius)
153.00
Boiling point (Kelvin)
426.15
General information
Molecular weight
73.10g/mol
Molar mass
73.0950g/mol
Density
0.9440g/cm3
Appearence

Dimethylformamide (DMF) is a colorless liquid that has a faint amine odor. It is miscible with water and the majority of organic liquids, making it a versatile solvent in various applications. In its pure form, DMF is stable enough for use in many chemical processes.

Comment on solubility

Solubility of N,N-Dimethylformamide (C3H7NO)

N,N-Dimethylformamide (DMF) is known for its excellent solubility characteristics, which make it a widely used solvent in various chemical reactions and processes. Here are some key points regarding its solubility:

  • Highly Soluble in Water: DMF is miscible with water in all proportions, allowing it to mix easily and form a homogeneous solution.
  • Solvent Versatility: It can dissolve a wide range of organic and inorganic compounds, including:
    • Salts
    • Polymers
    • Biomolecules
  • Polar Nature: The polarity of DMF facilitates solubility of polar solutes, as it can interact through dipole-dipole and hydrogen-bonding interactions.
  • Limited Solubility in Nonpolar Solvents: While it excels in polar environments, DMF has limited solubility in nonpolar solvents, making it less effective in those media.

In summary, N,N-dimethylformamide stands out due to its highly soluble nature, particularly in aqueous environments, enhancing its utility in chemical research and industrial applications. As it is often stated, "A good solvent is half the reaction!" and DMF embodies this principle effectively.

Interesting facts

Interesting Facts About N,N-Dimethylformamide

N,N-Dimethylformamide, commonly abbreviated as DMF, is a fascinating compound widely used in chemistry and industry. Here are some intriguing facts:

  • Solvent Powerhouse: DMF is known for its excellent solvent properties, making it invaluable in various chemical reactions, particularly in organic synthesis. Its ability to dissolve a wide range of polar and non-polar compounds is crucial for many laboratory and industrial processes.
  • Versatile Applications: DMF finds extensive use as a solvent for pharmaceuticals, plastics, and polymers. It plays a vital role in the production of synthetic fibers, paints, and coatings. Additionally, it serves as a reagent in the synthesis of numerous organic compounds.
  • Biological Activity: Research has shown that DMF possesses some biological properties, including anti-inflammatory and immunomodulating effects. It's even used in the treatment of skin conditions such as psoriasis, where it helps to reduce symptoms.
  • Safety Considerations: While DMF is a highly effective compound, it also requires careful handling. It can be absorbed through the skin and is classified as a potential reproductive toxin. Lab safety measures should always be adhered to when working with this compound.
  • Environmental Impact: As with many industrial chemicals, the environmental impacts of DMF have garnered attention. It is important to monitor its use and disposal to minimize pollution and adhere to environmental regulations.

In conclusion, N,N-dimethylformamide is not just a powerful solvent but also a compound with diverse applications and safety concerns. As a _chemical scientist_, understanding both its benefits and risks is essential for responsible use in research and industry.

Synonyms
N,N-DIMETHYLFORMAMIDE
Dimethylformamide
68-12-2
Dimethyl formamide
N,N-Dimethylmethanamide
N-Formyldimethylamine
Formamide, N,N-dimethyl-
Dimethylformamid
DMF
DMFA
Dimetilformamide
Dwumetyloformamid
Formyldimethylamine
N,N-Dimethyl formamide
Dimetylformamidu
DMF (amide)
Dimethylforamide
NCI-C60913
N,N Dimethylformamide
Dimethylamid kyseliny mravenci
Caswell No. 366A
dimethyl-Formamide
n,n,dimethylformamide
N,N-Dimetilformamida
HSDB 78
CCRIS 1638
DTXSID6020515
U-4224
NSC 5356
NSC-5356
Formic acid, amide, N,N-dimethyl-
EINECS 200-679-5
MFCD00003284
EPA Pesticide Chemical Code 366200
UNII-8696NH0Y2X
CHEBI:17741
AI3-03311
n,n-dimethyl-Formamide
NSC5356
N,N- Dimethylformamide
8696NH0Y2X
N,N-Dimethylformaldehyde
DTXCID20515
EC 200-679-5
N,N-Dimethylformamid
DIMETHYLFORMAMIDE (MART.)
DIMETHYLFORMAMIDE [MART.]
N,N-Dimethylformamide, HPLC Grade
Dimetylformamidu [Czech]
Dimethylformamid [German]
N,N-DIMETHYLFORMAMIDE (IARC)
N,N-DIMETHYLFORMAMIDE [IARC]
Dimetilformamide [Italian]
Dwumetyloformamid [Polish]
CAS-68-12-2
MFCD00003286
N,N-Dimetilformamida [Spanish]
DMF; Dimethylformamide; N,N-Dimethylformamide
N,N-Dimethylformamide, for HPLC, >=99.9%
N, N-dimethylformamide
N,N-Dimethylformamide, ACS reagent, >=99.8%
N, N-dimethyl formamide
UN2265
Dimethylamid kyseliny mravenci [Czech]
dimethlforamide
dimethlformamide
dimethyformamide
dimetylformamide
dimehtylformamide
dimethlyformamide
dimethyiformamide
dimethy formamide
dimethy1formamide
dimethyl foramide
dimethyl formamid
dimehtylformarnide
dimethylformarnide
dimethylforrnamide
dirnethylformamide
di-methylformamide
dimethylf ormamide
dimethylform amide
dimethylform-amide
dimethylformamid e
dimethylformamide-
dirnethylformarnide
n-dimethylformamide
dimethyl form-amide
dimethyl- formamide
dimethylfor- mamide
N,n-dimethylforamide
formamide, dimethyl-
N,N-dimethlformamide
N,N-dimethyformamide
N,N-dimetylformamide
n,n.dimethylformamide
N,N'dimethylformamide
N,N-dimethvlformamide
N.N-dimethylformamide
HCONMe2
Formamide,N-dimethyl-
N, N-dimethylforamide
N,N'-dimethylforamide
N,N-dimethl formamide
N,N-dimethy formamide
N,N-dimethyl foramide
N,N-dimethyl formamid
N,N-dimethylformarnide
N,N-dimethylforrnamide
N,N-dimetyl formamide
N,N-dirnethylformamide
n,n,-dimethylformamide
N, N dimethylformamide
N,N -dimethylformamide
N,N dimethyl formamide
N,N' dimethylformamide
N,N-di methylformamide
N,N-di-methylformamide
N,N-dime-thylformamide
N,N-dimehtyl formamide
N,N-dimethylfor mamide
N,N-dimethylfor-mamide
N,N-dimethylform-amide
N,N-dimethylformamide-
N,N-di-methylforrnamide
Dimethyl Fornamide,(S)
DMF (dimethylformamide)
n,n,-dimethyl formamide
N, N'-dimethylformamide
N, N- dimethylformamide
N, N-di-methylformamide
N, N-dimethyl-formamide
N,N- dimethyl formamide
N,N-di-methyl formamide
N,N-di-methyl-formamide
N,N-dimethyl -formamide
N,N-dimethyl- formamide
|N,N|-Dimethylformamide
N, N-dimethylformaldehyde
bmse000709
D.M.F
HCON(CH3)2
Dynasolve 100 (Salt/Mix)
BIDD:ER0600
WLN: VHN1&1
CHEMBL268291
D.M.F.
N,N-Dimethylformamide, 99.8%
N,N-Dimethylformamide, anhydrous
N,N-Dimethylformamide HPLC grade
N,N-Dimethylformamide, ACS grade
N,N-DIMETHYLFORMAMIDE [MI]
Tox21_201259
Tox21_300039
N,N-DIMETHYLFORMAMIDE [HSDB]
N,N-Dimethylformamide, biotech grade
s6192
STL264197
N,N-Dimethylformamide, LR, >=99%
AKOS000121096
FORMIN ACID,AMIDE,N,N-DIMETHYL
DB01844
N,N-DIMETHYLFORMAMIDE [USP-RS]
N,N-DIMETHYLFORMAMIDE [WHO-DD]
UN 2265
N,N-Dimethylformamide, p.a., 99.8%
USEPA/OPP Pesticide Code: 366200
MSK000746-1000A
N,N-Dimethylformamide, AR, >=99.5%
NCGC00090785-01
NCGC00090785-02
NCGC00090785-03
NCGC00090785-04
NCGC00090785-05
NCGC00254093-01
NCGC00258811-01
SY010600
N,N-Dimethylformamide, analytical standard
N,N-Dimethylformamide, anhydrous, 99.8%
D0722
D0939
N,N-Dimethylformamide, anhydrous, amine free
NS00005138
N,N-Dimethylformamide [for Spectrophotometry]
N,N-Dimethylformamide, for HPLC, >=99.5%
C03134
N,N-Dimethylformamide, Spectrophotometric Grade
N,N-Dimethylformamide, AldraSORB(TM), 99.8%
N,N-Dimethylformamide, ReagentPlus(R), >=99%
A836012
N,N-Dimethylformamide, biotech. grade, >=99.9%
Q409298
InChI=1/C3H7NO/c1-4(2)3-5/h3H,1-2H
N,N-Dimethylformamide, p.a., ACS reagent, 99.8%
N,N-Dimethylformamide, SAJ first grade, >=99.0%
N,N-Dimethylformamide [UN2265] [Flammable liquid]
N,N-Dimethylformamide, anhydrous, ZerO2(TM), 99.8%
N,N-Dimethylformamide, for molecular biology, >=99%
N,N-Dimethylformamide, JIS special grade, >=99.5%
N,N-Dimethylformamide, UV HPLC spectroscopic, 99.7%
Z220615596
N,N-Dimethylformamide Solution in Acetonitrile, 1000ug/mL
N,N-Dimethylformamide, ACS spectrophotometric grade, >=99.8%
N,N-Dimethylformamide HPLC, UV-IR min. 99.9%, isocratic grade
N,N-Dimethylformamide, Vetec(TM) reagent grade, anhydrous, >=99.8%
Dimethylformamide, Pharmaceutical Secondary Standard; Certified Reference Material
N,N-Dimethylformamide, p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 99.8%
N,N-Dimethylformamide, puriss. p.a., ACS reagent, reag. Ph. Eur., >=99.8% (GC)
200-679-5