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Trimeprazine hydrochloride

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Identification
Molecular formula
C18H22ClN3S2
CAS number
5086-74-8
IUPAC name
N,N,2-trimethyl-3-(2-methylsulfanylphenothiazin-10-yl)propan-1-amine;hydrochloride
State
State
At room temperature, Trimeprazine hydrochloride exists as a solid, particularly in the form of crystals. The stability in its solid form allows it to be used commonly in pharmaceutical formulations.
Melting point (Celsius)
193.00
Melting point (Kelvin)
466.15
Boiling point (Celsius)
270.00
Boiling point (Kelvin)
543.15
General information
Molecular weight
370.93g/mol
Molar mass
370.9310g/mol
Density
1.1600g/cm3
Appearence
The compound appears as a white or almost white crystalline powder. It is soluble in water and may have a slight odor characteristic of amines.
Comment on solubility

Solubility of N,N,2-trimethyl-3-(2-methylsulfanylphenothiazin-10-yl)propan-1-amine;hydrochloride

The solubility of the compound N,N,2-trimethyl-3-(2-methylsulfanylphenothiazin-10-yl)propan-1-amine;hydrochloride is greatly influenced by its ionic form as a hydrochloride salt. Generally, such salts tend to exhibit favorable solubility in polar solvents, particularly in:

  • Water: Hydrochloride salts usually dissolve well due to their ability to interact with water molecules.
  • Alcohols: Compounds like ethanol or methanol can also facilitate dissolution.

However, the presence of the complex aromatic and sulfur-containing moieties in this compound can lead to variations in solubility:

  • The bulky groups may hinder solubility compared to smaller, simpler amines.
  • The aromatic phenothiazine part might have limited solubility in non-polar solvents due to its hydrophobic character.

As a result, one might observe the following potential solubility behavior:

  1. High solubility in aqueous media for its hydrochloride form.
  2. Moderate solubility in alcohols.
  3. Low solubility in non-polar solvents such as hexane.

In conclusion, while the hydrochloride form enhances solubility in water, the overall solubility profile of this compound can be complex, necessitating careful consideration of the solvent's polarity and the compound's structure during any practical application.

Interesting facts

Interesting Facts about N,N,2-Trimethyl-3-(2-Methylsulfanylphenothiazin-10-yl)propan-1-amine; Hydrochloride

N,N,2-Trimethyl-3-(2-methylsulfanylphenothiazin-10-yl)propan-1-amine; hydrochloride is a fascinating compound that belongs to the class of organic compounds known as phenothiazines. These compounds are notable for their diverse applications in pharmaceuticals, particularly in the field of psychiatry and neurology.

Key Highlights:

  • Therapeutic Use: Phenothiazines have been widely used as antipsychotic medications, significantly impacting the treatment of schizophrenia and other mental health disorders.
  • Unique Structure: The presence of a trimethylamino group in this compound enhances its solubility and biological activity, making it an interesting target for medicinal chemistry.
  • Role of Sulfur: The inclusion of a methylsulfanyl group contributes to the compound's pharmacological properties, often increasing lipid solubility and allowing better membrane permeability.
  • Research Potential: Compounds of this class are continually being researched for new therapeutic applications, including their potential for treating neurodegenerative diseases.

As a scientist, it's essential to consider the mechanistic pathways through which such compounds exert their effects—often involving interactions with neurotransmitter receptors. The study of such compounds not only enhances our understanding of biological systems but also fuels the development of novel therapeutic agents.

Moreover, the rich chemistry associated with phenothiazine derivatives has led to a greater exploration of their interactions at the molecular level, prompting advances in drug design and the discovery of new pharmacophores.

In conclusion, N,N,2-trimethyl-3-(2-methylsulfanylphenothiazin-10-yl)propan-1-amine; hydrochloride serves as a prime example of how subtle structural modifications can lead to significant improvements in drug efficacy and safety profiles, making it a compound of interest in both academic research and clinical applications.

Synonyms
METHIOMEPRAZINE HYDROCHLORIDE
Methiomeprazine HCl
14056-64-5
UNII-P3V14N8PKW
EINECS 237-894-9
P3V14N8PKW
NSC-33234
10-(3-(Dimethylamino)-2-methylpropyl)-2-(methylthio)phenothiazine hydrochloride
2-Methylthio-10-(2-methyl-3-dimethylaminopropyl)phenothiazine hydrochloride
NSC 33234
10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-2-(methylthio)-, monohydrochloride
N,N,beta-Trimethyl-2-(methylthio)-10H-phenothiazine-10-propylaminemonohydrochloride
Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-2-(methylthio)-, hydrochloride
SKF 6270
RP 10584
10-[3-(Dimethylamino)-2-methylpropyl]-2-(methylthio)phenothiazine hydrochloride
(-)-10-(3-Dimethylamino-2-methylpropyl)-2-
(+-)-10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)-2-(METHYLTHIO)PHENOTHIAZINE MONOHYDROCHLORIDE
10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-2-(methylthio)-, monohydrochloride (9CI)
237-894-9
N,N,beta-Trimethyl-2-(methylthio)-10H-phenothiazine-10-propylamine monohydrochloride
N,N,2-trimethyl-3-(2-methylsulfanylphenothiazin-10-yl)propan-1-amine;hydrochloride
CHEMBL2106920
DTXSID60930874
NSC33234
Q27286095
WLN: T C666 BN ISJ B1Y1&1N1&1 ES1 &GH
(.+-.)-10-[3-(Dimethylamino)-2-methylpropyl]-2-(methylthio)phenothiazine monohydrochloride
10H-Phenothiazine-10-propanamine,N,.beta.-trimethyl-2-(methylthio)-, monohydrochloride
(+/-)-10-(3-(DIMETHYLAMINO)-2-METHYLPROPYL)-2-(METHYLTHIO)PHENOTHIAZINE MONOHYDROCHLORIDE
N,N,2-Trimethyl-3-[2-(methylsulfanyl)-10H-phenothiazin-10-yl]propan-1-amine--hydrogen chloride (1/1)