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Nitrofurazone

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Identification
Molecular formula
C6H6N4O4
CAS number
59-87-0
IUPAC name
N,N,3-trimethyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide
State
State

At room temperature, Nitrofurazone is in a solid state. It exists as a crystalline powder which is relatively stable at standard conditions.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
198.14g/mol
Molar mass
198.1560g/mol
Density
1.6154g/cm3
Appearence

Nitrofurazone appears as a yellow, crystalline solid. It has a distinctive bright yellow color which is typical for many nitro compounds. When crushed, it turns into a fine yellow powder that is sparingly soluble in water.

Comment on solubility

Solubility of N,N,3-trimethyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide

N,N,3-trimethyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide, with its complex structure, showcases intriguing solubility properties. This compound exhibits:

  • Moderate Solubility in Polar Solvents: It demonstrates a good level of solubility in polar solvents like water and ethanol, making it useful in various applications where such solvents are prevalent.
  • Poor Solubility in Non-Polar Solvents: Conversely, it tends to be poorly soluble in non-polar solvents such as hexane or toluene, which is typical for compounds possessing polar functional groups.
  • Influence of pH: The solubility may also vary with changes in pH, particularly due to the presence of the carboxamide group, which can affect ionization and solvation.

In summary, the solubility of N,N,3-trimethyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide exemplifies how molecular structure can dictate interactions with solvents, offering valuable insights for chemists in formulation and application development.

Interesting facts

Interesting Facts about N,N,3-Trimethyl-5-(5-Nitro-2-Furyl)Isoxazole-4-Carboxamide

N,N,3-Trimethyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide is a compound that stands out due to its unique chemical structure and potential applications. Here are some fascinating insights about this compound:

  • Structure and Functionality: The compound features a distinctive isoxazole core, which is characterized by a five-membered aromatic ring containing both nitrogen and oxygen. This structure plays a crucial role in its biological activity.
  • Biological Activity: Compounds containing the isoxazole moiety have shown promise in various biological systems, often exhibiting anti-inflammatory and antioxidant properties. This makes them of interest in medicinal chemistry.
  • Nitro Group Influence: The presence of the nitro group (–NO2) in the 5-position of the furan ring can significantly impact the compound's reactivity and pharmacodynamics, which can lead to developing new therapeutic agents.
  • Synthetic Versatility: The synthesis of this compound underscores the potential for creating diverse derivatives through modifications of the isoxazole or carboxamide groups, enabling exploration of a wide range of chemical behaviors.
  • Research Potential: Ongoing research into compounds like N,N,3-trimethyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide tackles important challenges such as drug resistance in pathogens, making it a compound of significant interest.

As highlighted by renowned chemists, “The beauty of chemistry lies not just in the molecules themselves but in the endless possibilities they present for innovation.” The exploration of such compounds is essential for enhancing our understanding of chemical interactions and their biological implications.


In summary, N,N,3-trimethyl-5-(5-nitro-2-furyl)isoxazole-4-carboxamide exemplifies the intersection of chemistry and biology, paving the way for advancements in drug development and therapeutic applications.

Synonyms
4-ISOXAZOLECARBOXAMIDE, 5-(5-NITRO-2-FURYL)-N,N,3-TRIMETHYL-
22997-03-1
5-(5-Nitro-2-furyl)-N,N,3-trimethyl-4-isoxazolecarboxamide
DTXSID70177551