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Nitrofurazone

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Identification
Molecular formula
C6H6N4O4
CAS number
59-87-0
IUPAC name
N',N',5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carbohydrazide
State
State

At room temperature, Nitrofurazone is a solid.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
198.16g/mol
Molar mass
198.1590g/mol
Density
1.6350g/cm3
Appearence

Nitrofurazone usually appears as a yellow crystalline powder. It has a characteristic odor and is known for its bright yellow color when in solid form.

Comment on solubility

Solubility of N',N',5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carbohydrazide

The solubility of N',N',5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carbohydrazide can be influenced by various factors including its molecular structure, polarity, and the nature of solvents used. Here are some key considerations:

  • Polarity: As a hydrazide derivative, this compound exhibits some polar characteristics, which can suggest moderate solubility in polar solvents.
  • Solvent Interaction: Common solvents such as water, methanol, and ethanol may aid in the dissolution process due to hydrogen bonding capabilities.
  • Temperature Dependency: Solubility can also increase with temperature, making the compound more soluble in warmer solutions.
  • Concentration Effects: The solubility might vary significantly under different concentration conditions, possibly leading to saturation points.

In summary, while the exact solubility data for N',N',5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carbohydrazide may be limited, understanding its structural attributes and the solvent environments can provide insights into its solubility behavior.

Interesting facts

Interesting Facts about N',N',5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carbohydrazide

N',N',5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carbohydrazide is a fascinating compound that belongs to the class of isoxazoles, which are notable for their various biological activities. Here are some engaging aspects of this compound:

  • Structure and Function: The isoxazole ring in this compound is recognized for its role in the design of pharmaceuticals. Compounds featuring isoxazole units often exhibit antimicrobial, anti-inflammatory, and even antitumor properties.
  • Biological Importance: The presence of the nitro group (-NO2) attached to the furan ring enhances the biological activity of this compound, making it particularly interesting in medicinal chemistry for its potential as a drug candidate.
  • Synthetic Versatility: This compound can serve as a versatile intermediate in the synthesis of other complex molecules, showcasing the intricate relationship between chemical structure and reactivity. Its synthesis often involves multi-step reactions which can be a delightful challenge for organic chemists.
  • Research Trends: Current research has shown that modifications of such compounds can lead to the development of novel therapeutic agents. For instance, derivatives of this compound are being explored for their potential to combat antibiotic resistance, a growing concern in modern medicine.
  • Environmental Impact: The study of isoxazole derivatives like this one is essential not only for their medicinal properties but also for evaluating their environmental persistence and toxicity, which are critical factors in drug development.

In conclusion, N',N',5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carbohydrazide exemplifies the intersection of chemistry, biology, and the pharmaceutical field. As scientists continue to explore and manipulate these compounds, they open the door to innovative solutions that can address various health challenges faced by society.

Synonyms
4-ISOXAZOLECARBOXYLIC ACID, 5-METHYL-3-(5-NITRO-2-FURYL)-, 2,2-DIMETHYLHYDRAZIDE
22996-95-8
5-Methyl-3-(5-nitro-2-furyl)-4-isoxazolecarboxylic acid 2,2-dimethylhydrazide
DTXSID20177546