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Nifuroxazide

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Identification
Molecular formula
C12H9N3O5
CAS number
965-52-6
IUPAC name
N,N,5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carboxamide
State
State

At room temperature, nifuroxazide is in a solid state, specifically found as a crystalline powder. It is stable under standard conditions but should be stored properly to maintain its integrity and efficacy.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.15
General information
Molecular weight
275.25g/mol
Molar mass
275.2460g/mol
Density
1.4170g/cm3
Appearence

Nifuroxazide appears as a yellow crystalline powder. Its vibrant color is notable and can vary slightly depending on the purity and form.

Comment on solubility

Solubility of N,N,5-Trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carboxamide

The solubility of N,N,5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carboxamide in various solvents is a topic of interest, especially given its potential applications in various fields. Here are some key points to consider:

  • Water Solubility: This compound has limited solubility in water, which is common for many organic compounds, particularly those with large molecular structures.
  • Organic Solvents: It shows better solubility in organic solvents such as DMSO (dimethyl sulfoxide) and methanol.
  • Temperature Dependency: Its solubility may increase with temperature, as is typical for many solid compounds, thus allowing for higher concentrations at elevated temperatures.
  • pH Sensitivity: The solubility can also be pH dependent due to the presence of carboxamide and nitro groups, which might interact differently in varying pH conditions.

In conclusion, while the solubility in water remains a challenge for N,N,5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carboxamide, exploring its behavior in various organic solvents and under different conditions can yield valuable insights for practical applications. As they say, "A compound's solubility is often a compass guiding its reactivity and efficacy."

Interesting facts

Interesting Facts About N,N,5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carboxamide

N,N,5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carboxamide, a fascinating compound within the isoxazole family, exhibits remarkable potential in various fields, particularly in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Structural Significance: The isoxazole ring system is notable for its unique properties, making it a versatile framework in organic synthesis. This compound features a nitro group and a furyl substituent, which can enhance its biological activity.
  • Pharmacological Interest: Compounds like this one are of great interest in drug discovery due to their potential as anti-inflammatory and antitumor agents. Research into isoxazole derivatives often reveals promising leads in tackling various diseases.
  • Reactivity: The electron-withdrawing nature of the nitro group increases the reactivity of the compound, which can be exploited in further organic transformations. This makes it a candidate for developing more complex derivatives.
  • Biological Interactions: The ability of compounds containing isoxazole moieties to interact with biological targets, such as enzymes and receptors, renders them vital in understanding disease mechanisms and developing therapeutic strategies.
  • Chemical Versatility: Due to its functional groups, this compound can participate in a range of reactions such as nucleophilic substitutions, which may lead to novel derivatives with enhanced efficacy.

In summary, N,N,5-trimethyl-3-(5-nitro-2-furyl)isoxazole-4-carboxamide stands as a noteworthy example of how simple modifications in organic compounds can lead to profound implications in pharmacology and synthetic organic chemistry. As a potential lead in drug discovery, it highlights the intricate relationship between structure and function in the realm of chemical research.

Synonyms
4-ISOXAZOLECARBOXAMIDE, 3-(5-NITRO-2-FURYL)-N,N,5-TRIMETHYL-
22996-91-4
3-(5-Nitro-2-furyl)-N,N,5-trimethyl-4-isoxazolecarboxamide
DTXSID00177544