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Etomidate

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Identification
Molecular formula
C14H16ClN3O4
CAS number
33125-97-2
IUPAC name
O1-[2-(diethylamino)ethyl] O3-ethyl 2-(2-phenylethyl)propanedioate
State
State

At room temperature, this compound is a crystalline solid. It is typically stable under standard conditions of temperature and pressure.

Melting point (Celsius)
72.00
Melting point (Kelvin)
345.00
Boiling point (Celsius)
150.50
Boiling point (Kelvin)
423.60
General information
Molecular weight
344.42g/mol
Molar mass
344.4200g/mol
Density
1.1990g/cm3
Appearence

The compound appears as a white crystalline solid. Its crystalline nature and solid form are characteristic for organic esters of this nature and it has minimal odor. It is typically available in pure forms for pharmaceutical uses.

Comment on solubility

Solubility of O1-[2-(diethylamino)ethyl] O3-ethyl 2-(2-phenylethyl)propanedioate

The solubility of O1-[2-(diethylamino)ethyl] O3-ethyl 2-(2-phenylethyl)propanedioate is influenced by its chemical structure, which presents both polar and non-polar characteristics. This dual nature suggests that the solubility behavior can vary significantly depending on the solvent used.

Factors Affecting Solubility

Key factors to consider when evaluating the solubility of this compound include:

  • Polarity: The presence of the diethylamino group enhances polar interactions, which may facilitate solubility in polar solvents such as water or alcohols.
  • Hydrophobic Effects: Conversely, the phenylethyl group introduces hydrophobic traits, suggesting better solubility in non-polar solvents like hexane or chloroform.
  • Temperature: Increased temperatures typically improve solubility for solid compounds by providing the necessary energy to overcome intermolecular forces.

Solubility Insights

Considering these factors, it can be summarized that:

  • In polar solvents, the compound may exhibit moderate to good solubility due to hydrogen bonding and dipole interactions.
  • In non-polar solvents, solubility could be comparatively higher, attributed to the hydrophobic phenyl and ethyl groups.
  • Overall, the solubility of O1-[2-(diethylamino)ethyl] O3-ethyl 2-(2-phenylethyl)propanedioate is not straightforward and must be assessed based on the chosen solvent and environmental conditions.

Understanding the solubility characteristics is essential for applications involving this compound, influencing its usage and behavior in various chemical processes.

Interesting facts

Interesting Facts about O1-[2-(diethylamino)ethyl] O3-ethyl 2-(2-phenylethyl)propanedioate

This compound, known for its complex structure, presents a fascinating area of study in organic chemistry due to its diverse applications and chemical properties.

Key Features

  • Biological Activity: Compounds of this nature often have pharmaceutical relevance, making them candidates for drug discovery and development. Their interactions with biological systems can lead to the discovery of new therapeutic agents.
  • Synthetic Applications: Depending on the substituents present, this type of compound can be utilized in the synthesis of other important organic compounds. Its ethylene and phenylethyl components provide versatility in chemical reactions.
  • Structure-Activity Relationship (SAR): Studying this compound allows chemists to explore how changes in its molecular structure can influence biological activity, paving the way for modifications that enhance efficacy.

Chemical Insights

One of the exciting aspects of this compound is its potential for reactivity due to the presence of various functional groups:

  • The diethylamino group contributes basic properties, possibly affecting solubility and reactivity.
  • The propanedioate moiety adds a layer of acidity and electrophilicity, which can be crucial for reactivity in synthetic pathways.

Research Implications

Ongoing research in the field of medicinal chemistry often focuses on derivatives of compounds like this one to enhance targeted delivery and reduce side effects in drugs:

  • Investigating the effects of different side chains.
  • Understanding how the ethyl and phenylethyl groups influence binding to biological targets.

As such, O1-[2-(diethylamino)ethyl] O3-ethyl 2-(2-phenylethyl)propanedioate embodies both complexity and potential, making it a captivating subject for chemists and researchers alike.