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Nifedipine

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Identification
Molecular formula
C17H18N2O6
CAS number
21829-25-4
IUPAC name
O5-(1-benzyl-3-piperidyl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
State
State

Solid: At room temperature, nifedipine is in a solid state appearing as a yellow crystalline powder.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
432.90
Boiling point (Kelvin)
706.05
General information
Molecular weight
346.34g/mol
Molar mass
346.3350g/mol
Density
1.4440g/cm3
Appearence

Nifedipine is a yellow crystalline powder.

Comment on solubility

Solubility of O5-(1-benzyl-3-piperidyl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

The solubility of the compound C17H18N2O6 is influenced by various factors due to its complex structure. The presence of multiple functional groups, such as carboxylates and aromatic rings, suggests a diverse solubility profile. Here are some key aspects to consider:

  • Polarity: The compound’s polar functional groups may enhance its solubility in polar solvents like water.
  • Hydrogen bonding: Carboxylic groups can form hydrogen bonds, contributing to solubility in aqueous environments.
  • Aromatic interactions: The nitrophenyl portion might promote solubility in organic solvents due to π-π stacking interactions.
  • Temperature dependence: Solubility can vary significantly with temperature, often increasing as temperature rises.
  • pH sensitivity: The solubility may change with pH due to the acidic and basic nature of certain functional groups.

In summary, as one considers the solubility of C17H18N2O6, it is crucial to take into account the interplay between these factors. The statement that captures the essence of these interactions is: "Solubility encompasses a dance between chemical structure and the environment."

Interesting facts

Interesting Facts about O5-(1-benzyl-3-piperidyl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

The compound known as O5-(1-benzyl-3-piperidyl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is an intriguing member of the dihydropyridine family, known for its applications in medicinal chemistry.

Structural Highlights

  • Multifunctionality: This compound showcases a blend of various functional groups, enhancing its versatility in therapeutic applications.
  • Piperidine Ring: The presence of a piperidine moiety lends unique properties, often contributing to the compound's biological activity.
  • Nitro Group: The nitrophenyl group may provide interesting electronic characteristics, potentially affecting interactions with biological targets.

Biological Significance

Compounds like this have been explored for their potential:

  • Anti-hypertensive Properties: Dihydropyridines are known to exhibit calcium channel blocking activities, making them significant in managing hypertension.
  • Cardioprotective Effects: Research suggests that such compounds may also contribute to cardioprotective effects, aiding in heart health.

Future Directions

As research progresses, the following areas deserve attention:

  • Drug Design: The unique scaffold that this compound offers can inspire new drug designs targeting various conditions.
  • Structure-Activity Relationship Studies: Understanding how modifications affect biological activity will enhance the development of more effective drug candidates.

In summary, O5-(1-benzyl-3-piperidyl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is not just another chemical compound; it encapsulates the beauty of molecular diversity and holds promise in the realm of medicinal chemistry.

Synonyms
Coniel
91599-75-6
5-O-(1-benzylpiperidin-3-yl) 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
3-Methyl 5-[1-(phenylmethyl)-3-piperidinyl] 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl1-(phenylmethyl)-3-piperidinyl ester, [R-(R*,S*)]-
3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl1-(phenylmethyl)-3-piperidinyl ester, [S-(R*,S*)]-
3-Methyl 5-(1-(phenylmethyl)-3-piperidinyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
SCHEMBL24517
GTPL10159
BDBM642533
DTXSID401107659
RDA59975
US20230414632, Compound I-f
PD033058