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Nifedipine

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Identification
Molecular formula
C17H18N2O6
CAS number
21829-25-4
IUPAC name
O5-(1-benzylpyrrolidin-3-yl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
State
State

At room temperature, Nifedipine is in a solid state. It is commonly utilized in the form of tablets or capsules in the pharmaceutical industry, emphasizing its stability in solid form under ambient conditions.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
611.80
Boiling point (Kelvin)
884.95
General information
Molecular weight
346.34g/mol
Molar mass
346.3360g/mol
Density
1.2820g/cm3
Appearence

Nifedipine appears as a yellow crystalline powder. It may also appear as bright yellow crystals under certain conditions. It is light sensitive and must be protected from light to maintain its stability and appearance.

Comment on solubility

Solubility of O5-(1-benzylpyrrolidin-3-yl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

The solubility of this compound, represented by the formula C17H18N2O6, can be characterized by several important factors:

  • Polarity: With the presence of multiple carboxylate groups, the molecule exhibits a degree of polarity, which generally favors solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility in polar environments, allowing interaction with solvent molecules.
  • Organic Solvents: Due to its organic structure, this compound may also show solubility in organic solvents such as ethanol or acetone, which can accommodate non-polar regions of the molecule.
  • Temperature Effects: As with many compounds, solubility can increase with temperature, promoting better dissolution in solvents at elevated amounts.

Moreover, it is essential to consider that while the compound's structure provides clues to its solubility behavior, actual solubility must be determined experimentally. Solubility plays a crucial role in various chemical applications, influencing aspects such as bioavailability and reactivity. Thus, understanding the solubility of O5-(1-benzylpyrrolidin-3-yl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is key to harnessing its potential in pharmaceutical and industrial contexts.

Interesting facts

Interesting Facts about O5-(1-benzylpyrrolidin-3-yl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

This intriguing compound, a derivative of dihydropyridine, is notable for its complex structure that contains multiple functional groups contributing to its unique properties. Here are some fascinating aspects to consider:

  • Biological Relevance: Compounds like this one have shown potential in therapeutic applications, particularly in cardiovascular research and neuropharmacology. Dihydropyridines are known for their ability to act as calcium channel blockers, thus playing a pivotal role in managing hypertension.
  • Structure-Activity Relationship: The presence of both benzyl and nitrophenyl groups suggests interesting electronic and steric effects, potentially enhancing the compound's biological activity. Understanding how these moieties influence the overall reactivity can yield essential insights in medicinal chemistry.
  • Synthetic Pathways: The synthesis of this compound may involve intricate steps, including multi-component reactions and careful selection of reagents to ensure high yields of the desired product. This highlights the advancements in synthetic methodologies in modern chemistry.
  • Potential for Modification: Given its tailored substituents, there is significant scope for structural modifications to optimize pharmacological effects. Researchers may explore variations in the substituents to improve selectivity or reduce side effects in drug development.

In conclusion, O5-(1-benzylpyrrolidin-3-yl) O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate stands out as a prime candidate for further exploration in pharmaceutical sciences, offering pathways for innovation and discovery in novel therapeutic agents.

Synonyms
104713-75-9
3-(1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
71863-55-3
SCHEMBL2537251
VXMOONUMYLCFJD-UHFFFAOYSA-N
DB-040559
(+)-(3\'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
(+/-)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-(1-benzylpyrrolidin-3-yl)ester-5-methyl ester
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl) ester 5-methyl ester
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl)ester 5-methyl ester