Nifedipine

Identification

Molecular formula

C₁₇H₁₈N₂O₆

CAS number

21829-25-4

IUPAC name

O5-ethyl O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

State

At room temperature, nifedipine is in a solid state, specifically as a crystalline powder. Care should be taken to keep it under proper storage conditions to maintain its efficacy and stability.

Melting point (Celsius)

172.50

Melting point (Kelvin)

445.65

Boiling point (Celsius)

494.30

Boiling point (Kelvin)

767.45

General information

Molecular weight

346.33g/mol

Molar mass

346.3240g/mol

Density

1.4036g/cm³

Appearence

Nifedipine appears as a yellow crystalline powder. It is relatively insoluble in water but soluble in ethanol and acetone. The compound is known for its light-sensitive nature and should be protected from exposure to light to preserve its stability.

Comment on solubility

Solubility of O₅-ethyl O₃-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Understanding the solubility of the compound C₁₇H₁₈N₂O₆ reveals several interesting characteristics:

Polarity: The presence of the nitrophenyl group and multiple carboxylate (-COOH) functions suggests a degree of polarity, which could enhance solubility in polar solvents like water.
Solvent Interaction: It is expected to exhibit poor solubility in non-polar solvents due to its polar functional groups, while solubility in organic solvents (e.g., ethanol, acetone) may be moderate.
Hydrogen Bonding: Potential for intramolecular and intermolecular hydrogen bonding may influence its solubility; compounds capable of hydrogen bonding typically demonstrate better solubility in polar environments.

In conclusion, while exact solubility may require empirical testing, predictions suggest that it will be more soluble in polar solvents than in non-polar mediums. Understanding these solubility traits can be crucial for its practical applications and formulation in various chemical processes.

Interesting facts

Interesting Facts about O⁵-ethyl O³-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

This fascinating compound, a member of the dihydropyridine class, showcases the intricate beauty of organic chemistry. Here are some intriguing aspects:

Pharmacological Potential: Dihydropyridines are renowned for their biological activities, particularly in the field of cardiovascular medicine. This compound may exhibit properties that could lead to the development of new medications aimed at treating hypertension and angina.
Nitrophenyl Group: The presence of a nitrophenyl group in its structure often signifies interesting electronic properties. This moiety can play a crucial role in various chemical reactions and may influence the compound's reactivity and stability.
Multi-functional Nature: The existence of multiple carboxylate groups in its structure highlights the compound's versatility. This could pave the way for applications in drug design, agrochemicals, or even materials science.
Structure-Activity Relationship (SAR): Studying the substitution patterns of this compound could offer insights into how variations affect its biological activity, thus assisting researchers in optimizing therapeutic agents.

In conclusion, O⁵-ethyl O³-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is not just a complex organic molecule; it embodies the intersection of synthetic chemistry and potential biomedical applications, inspiring scientists to explore its full capabilities.

Synonyms

nitrendipine

39562-70-4

Bayotensin

Baypress

Nidrel

Deiten

Nitrendipinum

Nitrendipin

Nitrendipino

Nitrepin

Bay-e-5009

Bylotensin

BAY e 5009

3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Nitrendipinum [INN-Latin]

Nitrendipino [INN-Spanish]

Baypress (TN)

CHEBI:7582

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

EINECS 254-513-1

MFCD00082255

NSC-758466

BRN 0498823

DTXSID0023373

Nitrendipine [USAN:INN:BAN:JAN]

NITRENDIPINE [MI]

NITRENDIPINE [INN]

NITRENDIPINE [JAN]

9B627AW319

NITRENDIPINE [USAN]

NITRENDIPINE [MART.]

ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

NITRENDIPINE [WHO-DD]

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester

MLS000069349

DTXCID203373

NITRENDIPINE [EP IMPURITY]

NITRENDIPINE [EP MONOGRAPH]

5-O-ethyl 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Ethyl 1,4-dihydro-5-(acetoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridincarboxylat

NSC 758466

NCGC00015713-07

SMR000058366

Nitrendipinum (INN-Latin)

Nitrendipino (INN-Spanish)

NITRENDIPINE (MART.)

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester, (+/-)-

Baylotensin

NITRENDIPINE (EP IMPURITY)

NITRENDIPINE (EP MONOGRAPH)

O3-ethyl O5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

SR-01000075334

nitrendipina

UNII-9B627AW319

Nitrendipine,(S)

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester;Nitrendipine;Bayotensin

CAS-39562-70-4

Spectrum_001901

Nitrendipine (Standard)

Opera_ID_928

SpecPlus_000742

Prestwick0_000916

Prestwick1_000916

Prestwick2_000916

Prestwick3_000916

Spectrum2_001565

Spectrum3_000968

Spectrum4_001088

Spectrum5_001655

N-144

(.+/-.)-Nitrendipine

(+-)-Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

CBiol_001834

Lopac0_000881

Oprea1_472855

Oprea1_703261

SCHEMBL38972

BSPBio_000792

BSPBio_001399

BSPBio_002575

KBioGR_000119

KBioGR_001476

KBioSS_000119

KBioSS_002432

MLS000759400

MLS001148149

MLS001424133

MLS002153303

MLS002154060

(+/-)-NITRENDIPINE

DivK1c_006838

Nitrendipine, >95%, powder

SPECTRUM1503609

SPBio_001470

SPBio_002981

BPBio1_000872

GTPL2334

CHEMBL3195219

HY-B0424R

KBio1_001782

KBio2_000119

KBio2_002426

KBio2_002687

KBio2_004994

KBio2_005255

KBio2_007562

KBio3_000237

KBio3_000238

KBio3_001795

BRD6392

C08CA08

Nitrendipine (JP18/USAN/INN)

Bio1_000120

Bio1_000609

Bio1_001098

Bio2_000119

Bio2_000599

HMS1361F21

HMS1570H14

HMS1791F21

HMS1989F21

HMS2051B04

HMS2089H15

HMS2093G17

HMS2097H14

HMS2230F04

HMS3262B04

HMS3266B03

HMS3371J07

HMS3393B04

HMS3402F21

HMS3411I14

HMS3651F05

HMS3675I14

HMS3714H14

HMS3884H21

Pharmakon1600-01503609

BCP07540

BRD-6392

HY-B0424

MSK10230

Nitrendipine for peak identification

Tox21_110201

Tox21_500881

AC-648

BBL028163

BDBM50237611

CA-212

CCG-39343

NSC758466

STK368903

AKOS000622913

AKOS015894921

AKOS016340326

Tox21_110201_1

CCG-100991

DB01054

IM57947

KS-1305

LP00881

NC00241

SDCCGSBI-0050856.P004

IDI1_033869

NCGC00015713-04

NCGC00015713-05

NCGC00015713-06

NCGC00015713-08

NCGC00015713-09

NCGC00015713-10

NCGC00015713-11

NCGC00015713-13

NCGC00015713-26

NCGC00024013-02

NCGC00024676-02

NCGC00024676-03

NCGC00024676-04

NCGC00024676-05

NCGC00024676-06

NCGC00024676-07

NCGC00261566-01

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester, (+-)-

IM175687

PD003069

PD033036

SY058769

(+/-)-BAY-E-5009

SBI-0050856.P003

Nitrendipine 100 microg/mL in Acetonitrile

AB00513962

EU-0100881

N1186

NS00007571

S2491

SW219737-1

A10804

C07713

D00629

AB00053154-03

AB00053154_04

AB00053154_05

EN300-18434855

Q416584

SR-01000075334-1

SR-01000075334-2

SR-01000075334-4

SR-01000075334-6

BRD-A02006392-001-06-5

BRD-A02006392-001-09-9

BRD-A02006392-001-15-6

BRD-A02006392-001-16-4

BRD-A02006392-001-17-2

Z239859926

Nitrendipine, European Pharmacopoeia (EP) Reference Standard

(.+/-.)-Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

(RS)-Methyl ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid ethyl methyl ester

3-Ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate #

3-ethyl5-methyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

methylethyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Nitrendipine for peak identification, European Pharmacopoeia (EP) Reference Standard

(+/-)-ETHYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE

(RS)-Methyl ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate - EP Grade

254-513-1

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester, (.+/-.)-

Solubility of O5-ethyl O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Interesting Facts about O5-ethyl O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Solubility of O₅-ethyl O₃-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Interesting Facts about O⁵-ethyl O³-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate