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Tetrandrine

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Identification
Molecular formula
C38H42N2O6
CAS number
518-34-3
IUPAC name
O8-[3-[6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] O1-[3-[6,7-dimethoxy-2-methyl-8-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] oct-4-enedioate
State
State

At room temperature, tetrandrine is typically a solid. It is known for its poor solubility in water but is soluble in organic solvents like ethanol and chloroform.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
745.50
Boiling point (Kelvin)
1 018.65
General information
Molecular weight
622.71g/mol
Molar mass
622.7140g/mol
Density
1.3146g/cm3
Appearence

Tetrandrine is a white to off-white crystalline powder. It is generally odorless and has a bitter taste.

Comment on solubility

Solubility of O8-[3-[6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] O1-[3-[6,7-dimethoxy-2-methyl-8-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] oct-4-enedioate

The solubility of this complex organic compound can be influenced by multiple factors, including its molecular structure and the presence of functional groups. Generally, the following points can improve your understanding of its solubility:

  • Polarity: The presence of polar functional groups, such as methoxy (-OCH3) groups, can increase solubility in polar solvents like water.
  • Nonpolar Characteristics: Conversely, the hydrophobic nature of certain structural components may cause reduced solubility in aqueous environments.
  • Solvent Choice: This compound is likely to exhibit greater solubility in organic solvents (e.g., ethanol, dimethyl sulfoxide) than in water.
  • Temperature Effects: Like many organic compounds, solubility may increase with temperature, making hot solvents preferable in extraction processes.
  • pH Sensitivity: The ionic nature of the compound suggests it may demonstrate pH-dependent solubility characteristics based on the ionization of its functional groups.

In essence, while this compound may possess some degree of solubility, it is crucial to analyze the specific conditions and solvent systems to fully understand its solubility profile. As the famous chemist, Marie Curie, once said, "Nothing in life is to be feared, it is only to be understood." The same can be applied to the solubility of chemical compounds.

Interesting facts

Exploring the Fascinating Compound: O8-[3-[6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] O1-[3-[6,7-dimethoxy-2-methyl-8-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] oct-4-enedioate

This compound presents an intriguing example of complex organic chemistry, notably within the realm of isoquinoline derivatives. Isoquinolines are known for their diverse biological activities, making them significant in medicinal chemistry. This particular molecule signifies a synthesis that incorporates dimethoxy and trimethoxy phenyl groups, suggesting its potential for enhanced biological activity. Here are some fascinating details:

  • Isoquinoline Framework: The presence of the isoquinoline structure implies potential roles in pharmacology. Several isoquinoline derivatives have been recognized for their anti-cancer, anti-inflammatory, and anti-microbial properties.
  • Dimethoxy Substituents: The dimethoxy groups may influence the compound's interaction with receptors or enzymes, which can be pivotal in determining biological outcomes.
  • Trimethoxyphenyl Groups: The incorporation of trimethoxyphenyl moieties enhances the overall lipophilicity of the compound, potentially facilitating its passage through biological membranes.
  • Potential Applications: This compound could reveal new therapeutic approaches due to its multifaceted structure, making it an attractive subject for further research in drug discovery.
  • Synthesis Challenges: The intricate nature of its synthesis likely posed significant challenges, reflecting the advanced skills of chemists in organic synthesis techniques.

Within the multidisciplinary field of chemistry, compounds like this inspire questions and future directions:

Questions for Further Research:

  • What specific biological activities can be attributed to this compound?
  • How does the structure-activity relationship (SAR) operate in this context?
  • Can this molecule be modified for enhanced efficacy or reduced toxicity?

As a scientist or a student delving into the intricacies of organic compounds, engaging with such complex structures is not merely a study of chemical properties but a journey into potential therapeutic innovations. The excitement of discovering how a molecule may impact health and healing is what fuels ongoing research within chemistry!