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Tetrandrine

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Identification
Molecular formula
C38H42Cl2N2O6
CAS number
518-34-3
IUPAC name
O8-[3-[6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] O1-[3-[6,7-dimethoxy-2-methyl-8-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] oct-4-enedioate;dichloride
State
State
Tetrandrine is typically a solid at room temperature, commonly found in powder form.
Melting point (Celsius)
126.50
Melting point (Kelvin)
399.65
Boiling point (Celsius)
207.35
Boiling point (Kelvin)
480.50
General information
Molecular weight
622.66g/mol
Molar mass
622.6910g/mol
Density
1.1610g/cm3
Appearence

Tetrandrine is a white or off-white crystalline powder. It may appear slightly yellowish depending on purity and environmental exposure.

Comment on solubility

Solubility of O8-[3-[6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] O1-[3-[6,7-dimethoxy-2-methyl-8-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] oct-4-enedioate; dichloride

The solubility characteristics of this complex compound are crucial for understanding its potential applications and behavior in various environments. Given its structure, it is anticipated that:

  • Polarity: The presence of multiple methoxy groups and ionic characteristics indicates a degree of polarity, which may facilitate solubility in polar solvents such as water.
  • Solvent Interactions: It is likely to exhibit better solubility in organic solvents like ethanol or methanol due to its hydrophobic alkyl chains.
  • Influence of Chlorine Atoms: The dichloride nature of the compound may enhance its solubility profile by affecting intermolecular interactions.
  • Temperature Dependency: Solubility may vary with temperature; heightened temperatures can increase solubility in both polar and non-polar solvents.

In summary, while predicting the exact solubility requires experimental data, the structural features of this compound suggest it may be soluble in both polar and non-polar solvents to varying degrees. It is essential to consider solvent choice and concentration for optimal use in applications such as pharmaceuticals or chemical synthesis.

Interesting facts

Interesting Facts About O8-[3-[6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] O1-[3-[6,7-dimethoxy-2-methyl-8-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] oct-4-enedioate; dichloride

This compound is a fascinating example of a complex organic molecule that exhibits intriguing biological properties. Known for its structural intricacies, this compound contains a unique arrangement that includes:

  • Isoquinoline moieties: These cyclic structures are common in numerous natural products and have been linked to various pharmacological effects.
  • Trimethoxyphenyl groups: The presence of multiple methoxy groups in the phenyl ring boosts the compound's lipophilicity, potentially enhancing its ability to cross biological membranes.
  • Positively charged nitrogen: The isoquinolinium ion indicates that this compound could have interesting electrochemical properties.

In medicinal chemistry, compounds with such a structure are often investigated for their potential as:

  • Antioxidants: There is significant interest in how the structural components contribute to their ability to scavenge free radicals.
  • Anti-tumor agents: Many isoquinoline derivatives have shown promise in preclinical studies as anticancer agents.
  • Neurological applications: The modulation of neurotransmitter systems by compounds like this may offer insights into new treatments for neurodegenerative diseases.

As one studies the interactions and modifications of such compounds, it becomes clear that the balance between structure and function plays a crucial role in their biological activity. As late chemist Peter Agre once said, "Science is a way of thinking much more than it is a body of knowledge." Thus, every new compound presents an opportunity to broaden our understanding of chemistry and its applications.

In conclusion, the exploration of O8-[3-[6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] O1-[3-[6,7-dimethoxy-2-methyl-8-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] oct-4-enedioate; dichloride brings forth exciting possibilities for future research and therapeutic advancements.