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Glycidol

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Identification
Molecular formula
C3H6O2
CAS number
556-52-5
IUPAC name
oxiran-2-ylmethanol
State
State

At room temperature, glycidol is in a liquid state. It is stable under normal conditions but may be reactive with acids and bases.

Melting point (Celsius)
-54.00
Melting point (Kelvin)
219.15
Boiling point (Celsius)
167.00
Boiling point (Kelvin)
440.15
General information
Molecular weight
74.08g/mol
Molar mass
74.0800g/mol
Density
1.1171g/cm3
Appearence

Glycidol is a clear, colorless, and slightly viscous liquid. It has a faint odor reminiscent of an ether or sweet alcohol. Due to its physical properties as a liquid, it spreads smoothly across surfaces.

Comment on solubility

Solubility of Oxiran-2-ylmethanol

Oxiran-2-ylmethanol, with the chemical formula C3H6O2, exhibits interesting solubility properties. This compound is known for its polar characteristics, which significantly influence its behavior in various solvents.

Key points about the solubility of Oxiran-2-ylmethanol include:

  • Water Solubility: Due to the presence of a hydroxyl (-OH) group and the epoxide structure, Oxiran-2-ylmethanol is expected to be soluble in water. This is primarily because the molecule can form hydrogen bonds with water molecules.
  • Organic Solvents: It is also likely to be soluble in various polar organic solvents, such as ethanol and methanol, due to similar polar characteristics.
  • Nonpolar Solvents: Conversely, Oxiran-2-ylmethanol may have limited solubility in nonpolar solvents like hexane or benzene, where the polarity does not favor interactions.

As a general rule, the solubility of compounds like Oxiran-2-ylmethanol can be summarized by the phrase: "Like dissolves like." Thus, its polar nature tends to favor solubility in polar environments.

Understanding the solubility of this compound is essential in applications such as synthesis, where solvent choice plays a crucial role in reaction efficiency and product yield.

Interesting facts

Exploring Oxiran-2-ylmethanol

Oxiran-2-ylmethanol, commonly known in the scientific community for its unique structure and versatile applications, offers a fascinating glimpse into the realm of organic chemistry. This compound features an oxirane ring—a cyclic ether with a three-membered ring—which contributes to its reactivity and functional potential.

Key Attributes of Oxiran-2-ylmethanol:

  • Structural Versatility: The presence of both an oxirane and alcohol functional group makes this compound a key player in organic synthesis, allowing it to participate in various chemical reactions.
  • Importance in Synthesis: Oxiran-2-ylmethanol is often used as an intermediate in the production of more complex molecules, showcasing its value in pharmaceutical and agrochemical industries.
  • Reactive Nature: The strained oxirane ring is more reactive compared to other cyclic ethers, making it an excellent target for nucleophilic attacks, which can lead to a variety of transformation products.

As a chemistry student or researcher, one might appreciate how oxiran-2-ylmethanol serves as a bridge between simple and complex molecules, illustrating the art of synthetic methodology. Additionally, the ability to manipulate its structure opens the door to exploring the synthesis of valuable compounds such as:

  • Pharmaceuticals
  • Agricultural chemicals
  • Polymers

In the words of chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." Oxiran-2-ylmethanol exemplifies this philosophy, functioning as a foundational building block that inspires innovative chemical solutions across various fields.

Synonyms
GLYCIDOL
556-52-5
oxiran-2-ylmethanol
Oxiranemethanol
1-Propanol, 2,3-epoxy-
2,3-Epoxy-1-propanol
Glycide
Oxiranylmethanol
Epihydrin alcohol
3-Hydroxypropylene oxide
2-(Hydroxymethyl)oxirane
2,3-Epoxypropanol
Glycidyl alcohol
2-Oxiranemethanol
Epoxypropyl alcohol
Allyl alcohol oxide
Monoepoxide glycidol
Methanol, oxiranyl-
2,3-Epoxypropan-1-ol
3-Hydroxy-1,2-epoxypropane
1,2-Epoxy-3-hydroxypropane
1-Hydroxy-2,3-epoxypropane
2-Hydroxymethyloxiran
Hydroxymethyl ethylene oxide
NCI-C55549
NSC 46096
CCRIS 1052
HSDB 1819
EINECS 209-128-3
S54CF1DV9A
BRN 0383562
DTXSID4020666
CHEBI:30966
AI3-50540
D-L-GLYCIDOL
GLYCIDOL [HSDB]
GLYCIDOL [IARC]
GLYCIDOL [MI]
NSC-46096
R-2,3-epoxy-1-propanol
DTXCID60666
GLYCIDOL [EP IMPURITY]
EC 209-128-3
NSC46096
GLYCIDOL (IARC)
LEVODROPROPIZINE IMPURITY C [EP IMPURITY]
GLYCIDOL (EP IMPURITY)
2-Hydroxymethyl oxiran
LEVODROPROPIZINE IMPURITY C (EP IMPURITY)
Oxirane methanol
2,3Epoxypropanol
Methanol, oxiranyl
2Hydroxymethyloxiran
2,3Epoxy1propanol
3Hydroxypropylene oxide
EPIOL OH
1Propanol, 2,3epoxy
Oxyranyl Methyl Alcohol
2(Hydroxymethyl)oxirane
1,2Epoxy3hydroxypropane
1Hydroxy2,3epoxypropane
3Hydroxy1,2epoxypropane
Glycidol (ACGIH:OSHA)
2,3-Epoxy-1-propanol (ACGIH:OSHA)
209-128-3
404-660-4
(S)-Oxiranemethanol
(+/-)-Glycidol
(RS)-Glycidol
(RS)-3-hydroxy-1,2-epoxypropane
Oxiranemethanol, (R)-
Oxiranemethanol, (S)-
(oxiran-2-yl)methanol
(+/-)-Oxirane-2-methanol
C3H6O2
Glycidol (~90%)
5-17-03-00009 (Beilstein Handbook Reference)
Glycerolglycide
2-Oxiranylmethanol #
CAS-556-52-5
2,3-Epoxypropanol-1
UNII-S54CF1DV9A
Glycerol glycid
glycerol glycide
CCRIS 6389
CCRIS 6390
oxiranyl-methanol
2-Oxiranylmethanol
Hydroxymethyloxirane
Glycidol; Oxiran-2-ylmethanol; [(2RS)-Oxiran-2-yl]methanol; Levodropropizine EP impurity C; 2,3-epoxypropan-1-ol
Glycidol, 96%
(RS)-Oxiranemethanol
DL-GLYCIDOL
BRN 0079782
BRN 0079783
1-Propanol,3-epoxy-
WLN: T3OTJ B1Q
MLS002174255
CHEMBL1530150
(+/-)-2-(hydroxymethyl)oxirane
HMS3039K06
HY-Y1010
STR01325
Tox21_201309
Tox21_300301
MFCD00005147
MFCD00074873
STL483075
(+/-)-Glycidol, analytical standard
AKOS009031473
FG23681
PB43085
SB40756
SB44653
NCGC00090738-01
NCGC00090738-02
NCGC00090738-03
NCGC00090738-04
NCGC00253997-01
NCGC00258861-01
SMR001261426
SY013955
SY031944
CS-0016001
NS00006946
EN300-19950
A10767
EC 404-660-4
Glycidol Epoxypropyl alcohol 2,3-Epoxy-1-propanol
Q418265
F0001-1460
Z104476180
Levodropropizine impurity C, European Pharmacopoeia (EP) Reference Standard
(R)-3-Hydroxy-1,2-epoxypropane; (R)-Oxiranemethanol; (R)-(+)-Oxirane-2-methanol
(S)-(-)-Glycidol; (S)-(-)-2,3-Epoxy-1-propanol; (R)-3-Hydroxy-1,2-epoxypropane; [(2R)-Oxiran-2-yl]methanol