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Phenyl fluoroacetate

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Identification
Molecular formula
C8H7FO2
CAS number
403-42-9
IUPAC name
phenyl 2-fluoroacetate
State
State

At room temperature, phenyl fluoroacetate is in a liquid state.

Melting point (Celsius)
-24.00
Melting point (Kelvin)
249.15
Boiling point (Celsius)
191.00
Boiling point (Kelvin)
464.15
General information
Molecular weight
170.14g/mol
Molar mass
170.1570g/mol
Density
1.2120g/cm3
Appearence

Phenyl fluoroacetate is typically a colorless to pale yellow liquid. It has a characteristic odor that may be considered pleasant by some.

Comment on solubility

Solubility of Phenyl 2-Fluoroacetate

Pheyl 2-fluoroacetate, with the chemical formula C9H9F1O2, exhibits unique solubility characteristics that are influenced by its molecular structure. Here are some key points regarding its solubility:

  • Polar Nature: The presence of the fluoride atom and the carbonyl group contributes to a polar molecular environment, enhancing solubility in polar solvents.

  • Organic Solvents: Phenyl 2-fluoroacetate is expected to be soluble in common organic solvents, such as ethanol, acetone, and chloroform, due to favorable interactions with these solvents.

  • Water Solubility: Its solubility in water is likely limited, as the hydrophobic phenyl group tends to decrease overall water solubility.

  • Temperature Dependence: Like many organic compounds, solubility may vary with temperature, typically increasing as the temperature rises.

In conclusion, phenyl 2-fluoroacetate's solubility is dictated by its molecular interactions, making it more compatible with organic solvents than with water. Understanding these properties is crucial for its practical applications in chemical synthesis and analysis.

Interesting facts

Interesting Facts about Phenyl 2-Fluoroacetate

Phemyl 2-fluoroacetate is a fascinating compound that blends both the aromatic characteristics of phenyl groups with the notable reactivity of fluoroacetates. Here are some intriguing aspects of this compound:

  • Applications in Chemistry: Phenyl 2-fluoroacetate plays a key role in various synthetic pathways, especially in medicinal chemistry for the preparation of bioactive compounds.
  • Reactivity: The presence of the fluorine atom makes this compound a unique halogenated derivative, enhancing its electrophilic behavior which can influence reaction mechanisms.
  • Biological Interest: Compounds similar to phenyl 2-fluoroacetate have been studied for their potential as pharmaceutical intermediates, especially in the development of anti-cancer agents.
  • Environmental Considerations: As with many fluorinated compounds, the environmental impact of phenyl 2-fluoroacetate is a topic of discussion due to the stability of carbon-fluorine bonds, which can lead to persistence in ecosystems.
  • Chirality: Depending on the specific reaction conditions, this compound can exhibit chirality, making it an interesting subject for studies in stereochemistry and its implications in drug design.

In the words of renowned chemist Linus Pauling, “The best way to have a good idea is to have lots of ideas.” Exploring compounds like phenyl 2-fluoroacetate allows chemists to generate innovative ideas and further our understanding of complex chemical interactions.


Synonyms
Phenyl fluoroacetate
phenyl 2-fluoroacetate
404-15-9
ACETIC ACID, FLUORO-, PHENYL ESTER
SCHEMBL241908
DTXSID30960800