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Phenylhydrazine

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Identification
Molecular formula
C6H8N2
CAS number
100-63-0
IUPAC name
phenylhydrazine
State
State

At room temperature, phenylhydrazine is usually found as a liquid.

Melting point (Celsius)
19.60
Melting point (Kelvin)
292.75
Boiling point (Celsius)
243.00
Boiling point (Kelvin)
516.15
General information
Molecular weight
108.14g/mol
Molar mass
108.1420g/mol
Density
1.0974g/cm3
Appearence

Phenylhydrazine is typically found as a colorless to pale yellow liquid. However, it can darken upon exposure to air and light, developing a reddish-brown color. It may also appear to be slightly oily in texture.

Comment on solubility

Solubility of Phenylhydrazine

Pheylhydrazine, which has the chemical formula C6H7N3, exhibits interesting solubility characteristics.

General Solubility Behavior

Phenylhydrazine is known to be:

  • Soluble in polar organic solvents such as alcohol and ether, making it quite versatile for various applications.
  • Practically insoluble in water due to its hydrophobic aromatic structure.

Factors Influencing Solubility

The solubility of phenylhydrazine in various solvents can be influenced by several factors:

  • Temperature: As temperature increases, solubility generally improves, which is important in reaction conditions.
  • pH Levels: Interaction with acidic or basic environments can affect the solubility through protonation states.
  • Presence of Co-solvents: Using mixtures of solvents can enhance solubility due to differing polarities.

In summary, while phenylhydrazine shows a tendency to dissolve in certain organic solvents, its lack of solubility in water is a significant characteristic to consider in experimental applications.

Interesting facts

Interesting Facts About Phenylhydrazine

Pheylhydrazine, known for its role as a versatile reagent in organic chemistry, is an aromatic hydrazine derivative that has garnered attention due to its unique chemical properties and applications.

Key Characteristics:

  • Reactive Intermediate: It is commonly used to form various derivatives of carbonyl compounds, leading to the synthesis of azines, which are valuable in the development of pharmaceuticals.
  • Biological Importance: Phenylhydrazine can induce red blood cell production and has been utilized in research studying blood disorders and erythropoiesis.
  • Color Reactions: When reacting with sugars, phenylhydrazine can produce colored derivatives, making it a useful tool in carbohydrate chemistry.

Phenylhydrazine is not without its challenges; it is known to be toxic, and researchers must handle it with care. According to the National Institutes of Health, “It's important to study its reactivity and potential hazards to ensure safety in laboratory settings.” This underlines the need for proper safety protocols and education in handling chemical substances.

Applications in Research:

  • Synthesis: Used in the synthesis of pharmaceuticals, particularly in the formulation of antidiabetic agents.
  • Food Chemistry: Employed in the identification and quantification of reducing sugars.
  • Analytical Chemistry: Able to form derivatives that can be detected through various spectroscopic methods, expanding its utility in analytical applications.

In summary, phenylhydrazine stands out as a reagent with a wide variety of applications, particularly in synthesis and analytical chemistry. Its role in scientific research emphasizes the balance between utility and caution, making it an intriguing compound to study.

Synonyms
PHENYLHYDRAZINE
100-63-0
Hydrazinobenzene
Hydrazine, phenyl-
1-Phenylhydrazine
phenyl hydrazine
Monophenylhydrazine
Phenylhydrazin
Hydrazine-benzene
Fenilidrazina
Fenylhydrazine
Phenyldiazane
PhNHNH2
CCRIS 511
CHEBI:27924
phenyl-hydrazine
HSDB 1117
EINECS 202-873-5
UN2572
BRN 0606080
DTXSID8021147
UNII-064F424C9K
AI3-15399
HYDRAZINE,PHENYL
064F424C9K
UN 2572
PHENYLHYDRAZINE [MI]
PHENYLHYDRAZINE [HSDB]
DTXCID301147
PHENYLHYDRAZINE [WHO-DD]
EC 202-873-5
4-15-00-00050 (Beilstein Handbook Reference)
phenylhydrazide
Fenylhydrazine [Dutch]
Fenilidrazina [Italian]
Phenylhydrazin [German]
1-phenylhydrazine hydrochloride
CAS-100-63-0
NCGC00159378-02
NCGC00159378-04
aminoaniline
penylhydrazine
phenyihydrazine
Hydrazinebenzene
anilino nitrogen
phenylhy-drazine
N-phenylhydrazine
2-phenylhydrazine
hydrazine, phenyl
MFCD00007573
Phenylhydrazine, 97%
SCHEMBL7099
BIDD:ER0251
SCHEMBL491697
Phenylhydrazine Hydrazinobenzene
CHEMBL456807
Phenylhydrazine (ACGIH:OSHA)
YLVKIBKAGUPACT-UHFFFAOYSA-N
Tox21_201977
Tox21_303018
BBL011601
BDBM50444455
STL163333
AKOS000268993
AD-0218
FP34971
Phenylhydrazine [UN2572] [Poison]
NCGC00159378-03
NCGC00159378-05
NCGC00159378-06
NCGC00256354-01
NCGC00259526-01
BP-13438
Phenylhydrazine, purum, >=95.0% (GC)
NS00001148
P0183
EN300-32001
A23856
C02304
Q290862
Z1954801770
202-873-5