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Phthalazin-1-amine

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Identification
Molecular formula
C8H7N3
CAS number
274-64-0
IUPAC name
phthalazin-1-amine
State
State

At room temperature, phthalazin-1-amine exists as a solid. Its solid-state structure is primarily due to intermolecular forces that maintain its crystalline form.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.00
Boiling point (Celsius)
347.80
Boiling point (Kelvin)
620.95
General information
Molecular weight
147.16g/mol
Molar mass
147.1590g/mol
Density
1.1920g/cm3
Appearence

Phthalazin-1-amine appears as a crystalline solid. Its color can range from white to off-white. The compound is typically presented in a powder form and may also be available in other solid crystal structures depending on its synthesis and purity.

Comment on solubility

Solubility of Phthalazin-1-amine

Phthalazin-1-amine, with the chemical formula C8H6N2, exhibits unique solubility characteristics that are important in various chemical applications.

When evaluating its solubility, several key factors should be considered:

  • Polarity: Phthalazin-1-amine is a relatively polar compound due to the presence of amino groups, which can interact favorably with polar solvents.
  • Solvent Compatibility: It tends to be soluble in polar organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). This attribute is useful for its applications in organic synthesis.
  • Water Solubility: The solubility of phthalazin-1-amine in water is limited. This suggests that it may not dissolve efficiently in aqueous environments, which can constrain its utility in certain biochemical settings.

As a rule of thumb, compounds with more functional groups that can engage in hydrogen bonding are typically more soluble in water. However, due to the overall molecular structure of phthalazin-1-amine, its aqueous solubility remains modest.

In summary, while phthalazin-1-amine shows good solubility in various organic solvents, its solubility in water is limited. Researchers and chemists must take these factors into account when planning applications or reactions involving this compound.

Interesting facts

Interesting Facts about Phthalazin-1-amine

Phthalazin-1-amine, a compound notable for its unique structural properties, belongs to a class of organic compounds that have attracted significant attention in various fields, including medicinal chemistry and material science. Here are some intriguing aspects of this compound:

  • Chemical Structure: Phthalazin-1-amine features a fused ring system, comprising a phthalazine core which places it in a family of compounds that have similar structural motifs, often leading to varied biological activities.
  • Biological Activity: Research suggests that phthalazin-1-amine exhibits potential pharmacological properties, making it a subject of interest in drug design. Its derivatives have been investigated as potential agents for treating conditions such as cancer and tuberculosis.
  • Synthetic Versatility: The compound is notable for its *synthetic accessibility*, which allows it to be modified and utilized in various applications, including the development of novel therapeutic agents and materials.
  • Functionalization Possibilities: The presence of amino groups makes it amenable to further reactions, allowing chemists to create a plethora of derivatives that can enhance its properties, such as solubility and reactivity.
  • Research & Development: Ongoing studies are looking into its applications beyond pharmacology, including its use as a precursor in organic synthesis and as a building block for designing complex organic materials.

The versatility of phthalazin-1-amine in both medicinal and chemical applications highlights the importance of understanding its properties and potential. As researchers continue to unravel the mysteries surrounding this compound, it underscores the dynamic nature of organic chemistry.

Synonyms
phthalazin-1-amine
1-PHTHALAZINAMINE
19064-69-8
DTXSID70172561
DTXCID9095052
816-487-5
1-Aminophthalazine
Phthalazine, 1-amino-
aminophthalazine
phthalazineimine
SCHEMBL600018
SCHEMBL2010013
SCHEMBL2856946
SCHEMBL6494372
SCHEMBL14530406
SCHEMBL29560277
AKOS009542244
FA17828
CS-0448958
G74875
EN300-1601331
Z425847324