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Phthalazine

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Identification
Molecular formula
C8H6N2
CAS number
253-52-1
IUPAC name
phthalazine
State
State

Phthalazine exists as a solid at room temperature.

Melting point (Celsius)
90.00
Melting point (Kelvin)
363.15
Boiling point (Celsius)
251.90
Boiling point (Kelvin)
525.05
General information
Molecular weight
130.15g/mol
Molar mass
130.1490g/mol
Density
1.3050g/cm3
Appearence

Phthalazine is typically a white to light yellow solid. Its appearance can vary slightly based on its purity and conditions.

Comment on solubility

Solubility of Phthalazine

Phthalazine, a bicyclic compound with the formula C8H6N2, exhibits noteworthy solubility characteristics that are essential for its applications. Understanding its solubility can greatly impact its utilization in pharmaceuticals and material sciences.


Solubility Characteristics

  • Solvent Dependency: Phthalazine is typically sparingly soluble in water, which is a common trait among many aromatic nitrogen-containing compounds.
  • Organic Solvents: It shows better solubility in organic solvents such as ethanol, methanol, and acetone, making it easier to incorporate into various organic reactions.
  • Temperature Influence: Increasing temperature generally enhances the solubility of phthalazine in organic solvents, highlighting the thermal dependence of its dissolution processes.
  • pH Sensitivity: The solubility of phthalazine can be affected by the pH of the surrounding environment, which may influence its ionization state.

In summary, phthalazine's solubility profile is defined by its limited aqueous solubility, but favorable characteristics in organic solvents. This makes it a versatile compound in various chemical applications, despite its constrained solubility in water. Understanding these nuances can aid in optimizing its use in different fields.

Interesting facts

Interesting Facts about Phthalazine

Phthalazine is a fascinating compound that belongs to the family of aromatic heterocycles. Here's what makes it intriguing:

  • Aromatic Nature: Phthalazine offers extensive resonance stabilization due to its aromatic character, which contributes to its unique chemical properties.
  • Application in Dyes: It is often used as an intermediate in the synthesis of dyes, showcasing its importance in the colorants industry.
  • Biological Relevance: Phthalazine derivatives have been researched for their biological activity, particularly in relation to their potential anti-inflammatory and anticancer properties.
  • Pharmaceutical Potential: Some studies suggest that phthalazine and its derivatives might play a role in the development of drugs targeting specific biological pathways.
  • Synthetic Route: The synthesis of phthalazine generally involves the reaction of hydrazine with phthalic anhydride, highlighting the versatility of heterocyclic chemistry.

As a student or scientist, studying compounds like phthalazine not only enhances our understanding of aromatic systems but also underscores the significance of such molecules in various industrial and pharmaceutical applications. As expressed in the words of a noted chemist, "Understanding the intricacies of compounds like phthalazine is key to unlocking future innovations."

Moreover, the exploration of phthalazine within chemical literature continues to inspire research, emphasizing the compound's relevance in both chemistry and applied sciences.

Synonyms
PHTHALAZINE
253-52-1
2,3-Benzodiazine
Benzo[d]pyridazine
2,3-Diazanaphthalene
beta-Phenodiazine
Benzo(d)pyridazine
.beta.-Phenodiazine
MFCD00006908
CCRIS 6894
EINECS 205-963-2
NSC 62484
UNII-91Y28DM24N
DTXSID9049407
CHEBI:36597
91Y28DM24N
PHTHALAZINE [MI]
NSC-62484
PHTHALAZINE [USP-RS]
DTXCID8029367
PHTHALAZINE [USP IMPURITY]
PHTHALAZINE (USP-RS)
PHTHALAZINE (USP IMPURITY)
phthalazin
betaPhenodiazine
2,3Benzodiazine
2,3-Benzodiazine; 2,3-Diazanaphthalene; Benzo[d]pyridazine; NSC 62484; NSC 63241; ss-Phenodiazine
4FT
2,3Diazanaphthalene
Phthalazine, 98%
4,5-Benzopyridazine
SCHEMBL8266
BIDD:GT0069
CHEMBL1650268
BCP22288
NSC62484
NSC63241
Tox21_202907
NSC-63241
AKOS009157299
CS-W002016
HY-W002016
NCGC00260453-01
AS-15090
CAS-253-52-1
SY004474
NS00027869
P0694
EN300-50405
Q6593919
Phthalazine, United States Pharmacopeia (USP) Reference Standard
205-963-2