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2-Piperidone

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Identification
Molecular formula
C5H9NO
CAS number
675-20-7
IUPAC name
piperidin-2-one
State
State

2-Piperidone is a solid at room temperature, but it can also exist as a colorless liquid slightly above its melting point.

Melting point (Celsius)
38.00
Melting point (Kelvin)
311.15
Boiling point (Celsius)
229.00
Boiling point (Kelvin)
502.15
General information
Molecular weight
99.13g/mol
Molar mass
99.1310g/mol
Density
1.0320g/cm3
Appearence

2-Piperidone is a colorless liquid with a faint amine-like odor.

Comment on solubility

Solubility of Piperidin-2-one

Piperidin-2-one, with its chemical formula C5H9NO, exhibits interesting solubility properties that are important to consider in various applications. This compound is known to be:

  • Soluble in Water: Piperidin-2-one is moderately soluble in water, primarily due to the presence of the carbonyl group (C=O), which can interact favorably with water molecules.
  • Soluble in Organic Solvents: It is readily soluble in a range of organic solvents such as ethanol, methanol, and dichloromethane, making it versatile for use in organic synthesis.
  • Factors Influencing Solubility: The solubility may be influenced by factors like temperature and pH, altering its availability and reactivity in different environments.

According to solubility principles, the general rule states, "like dissolves like," meaning polar solvents will dissolve polar solutes. As such, the inherent polar characteristics of piperidin-2-one facilitate its dissolution in polar solvents while limiting its solubility in non-polar environments.

In summary, the solubility profile of piperidin-2-one makes it a valuable compound in various chemical processes, enabling its effective use in both aqueous and non-aqueous reactions.

Interesting facts

Interesting Facts about Piperidin-2-one

Piperidin-2-one, also known as 2-Piperidinone, is a fascinating compound that belongs to the family of cyclic amides. This unique structure and its diverse applications make it notable in various fields of research and industry.

Chemical Structure and Characteristics

  • Cyclic Nature: Piperidin-2-one features a six-membered ring with nitrogen, which is crucial for many biological activities.
  • Functional Groups: The presence of both a ketone and an amine in its structure contributes to its reactivity and interaction with other molecules.
  • Versatile Derivatives: Numerous derivatives of piperidin-2-one exist, each exhibiting different properties and functionalities.

Applications in Various Fields

  • Pharmaceuticals: It serves as a key building block in the synthesis of various pharmaceuticals, particularly in the development of analgesics and antipsychotic drugs.
  • Agrochemicals: Its derivatives are also utilized in the production of agrochemicals, aiding in pest and disease control.
  • Material Science: The compound has been explored in the development of polymers and other materials due to its unique chemical properties.

Research Insights

In research, piperidin-2-one has been highlighted for its biological activity. Studies suggest that compounds derived from piperidin-2-one possess:

  • Antibacterial properties
  • Antioxidant activity
  • Potential anti-cancer effects

As noted by some researchers, "The potential applications of piperidin-2-one derivatives continue to inspire innovative drug design and synthesis."

Conclusion

In summary, piperidin-2-one is not just a simple cyclic compound; it is a vital ingredient in the field of chemistry, paving the way for numerous advancements in pharmaceuticals and material science. Its unique structure and varying properties promise continued research and exploration in modern science.

Synonyms
2-Piperidone
piperidin-2-one
675-20-7
DELTA-VALEROLACTAM
2-Piperidinone
Valerolactim
5-Pentanolactam
Piperidone
Piperidinone
Valerolactam
Piperidon
alpha-Piperidone
Piperidone-2
PIPERIDONE,2-
.alpha.-Piperidone
2-oxopiperidine
2-Azacyclohexanone
Piperidon [German]
Pentanoic acid, 5-amino-, lactam
.delta.-Valerolactam
2-oxo-piperidine
NSC 2305
NSC 18894
WLN0GQQ6EK
MFCD00006037
CHEMBL12193
27154-43-4
CHEBI:77761
NSC-2305
NSC18894
Piperidon (german)
NSC-18894
Pentanoic acid, lactam
WLN: T6NVTJ
Piperidones
Piperidone-2 [French]
d-Valerolactam
UNII-WLN0GQQ6EK
EINECS 211-622-9
ketopiperidine
oxopiperidine
5-pentanelactam
2-piperadinone
A-Piperidone
AI3-33342
d-Valero-lactam
piperadine-2-one
piperidine-2-one
delta -Valerolactam
V1L
5-amino-lactam-Pentanoate
delta-Valerolactam, 98%
BDBM10
5-amino-lactam-Pentanoic acid
piperidin-2-one;2-Piperidone
DTXSID1060976
NSC2305
BCP00878
Piperidin-2-one; delta-Valerolactam
BBL027557
STL281850
AKOS005206867
CS-W022933
FP09656
HY-W042193
SB41073
AC-15619
AC-33837
NCI60_001574
SY011119
DB-031244
A9047
NS00015672
P0455
EN300-24025
F10312
Q4596918
F0001-1780
Z168817684
InChI=1/C5H9NO/c7-5-3-1-2-4-6-5/h1-4H2,(H,6,7
25036-00-4