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3-Piperidinol

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Identification
Molecular formula
C5H11NO
CAS number
6859-99-0
IUPAC name
piperidin-3-ol
State
State

At room temperature, 3-Piperidinol is a crystalline solid.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
222.00
Boiling point (Kelvin)
495.15
General information
Molecular weight
101.15g/mol
Molar mass
101.1540g/mol
Density
1.0234g/cm3
Appearence

3-Piperidinol appears as a colorless or white solid crystalline powder. It might also exist as pale yellow, depending on its purity and method of preparation.

Comment on solubility

Solubility of Piperidin-3-ol

Piperidin-3-ol, with the chemical formula C5H11NO, demonstrates interesting solubility characteristics that are worth noting:

  • Polar Nature: Due to the presence of the hydroxyl group (-OH), piperidin-3-ol exhibits a polar nature, which significantly influences its solubility.
  • Water Solubility: Piperidin-3-ol is highly soluble in water. This high solubility can be attributed to hydrogen bonding between the hydroxyl groups and water molecules.
  • Organic Solvents: In addition to its solubility in water, piperidin-3-ol is also soluble in various organic solvents. Examples include:
    • Alcohols
    • Amines
    • Aromatic compounds

To quote, "The solubility of a compound is vital for its application in various chemical reactions and processes." In the case of piperidin-3-ol, its solubility enhances its utility in the synthesis of pharmaceuticals and other chemical products. Understanding these solubility characteristics is crucial for chemists working with this compound.

Interesting facts

Interesting Facts About Piperidin-3-ol

Piperidin-3-ol is a fascinating compound that belongs to the family of piperidine derivatives. Here are some key points that highlight its significance in various fields:

  • Structural Features: Piperidin-3-ol is characterized by a six-membered saturated ring containing one nitrogen atom and a hydroxyl group (-OH) at the third carbon position. This unique structure imparts interesting chemical properties.
  • Potential Pharmacological Applications: The compound is noted for its potential use in pharmaceuticals. Its structural resemblance to other biologically active compounds enables researchers to explore its effectiveness in treating various conditions, including pain and neurological disorders.
  • Organic Synthesis: Piperidin-3-ol serves as an important intermediate in organic synthesis, facilitating the development of complex molecules. Its availability and reactivity make it a valuable building block in the synthesis of more intricate chemical entities.
  • Research Interest: Scientists are keenly interested in the derivatives of piperidin-3-ol because they exhibit diverse biological activities. Innovations in medicinal chemistry often stem from modifications to its structure, leading to the discovery of new therapeutic agents.
  • Historical Context: Compounds related to piperidine have been studied for over a century. Piperidin-3-ol exemplifies how foundational research continues to pave the way for advancements in chemical and medicinal applications.

In summary, *piperidin-3-ol* is not merely a chemical entity; it represents a bridge between basic research and practical applications in medicine and industry. As the landscape of science evolves, the exploration of this compound and its derivatives promises exciting new findings.

Synonyms
3-Hydroxypiperidine
Piperidin-3-ol
6859-99-0
3-Hydroxyhexahydropyridine
EINECS 229-957-4
NSC 62082
229-957-4
biwosrskdczifm-uhfffaoysa-n
3-PIPERIDINOL
3-hydroxy piperidine
MFCD00014591
(+/-)-3-HYDROXYPIPERIDINE
NSC-62082
3-Hydroxypiperadine
MFCD08669819
MFCD09832542
piperidine-3-ol
(+/-)-3-Piperidinol; (R,S)-3-Hydroxypiperidine; (+/-)-3-Hydroxypiperidine; 3-Hydroxyhexahydropyridine; NSC 62082
NSC62082
3-hydroxy-piperdine
3-hydroxy-piperidine
3-hydroxyl piperidine
5-hydroxyl piperidine
(3rs)-3-piperidinol
(3S)-3-Piperidinol; (S)-3-Hydroxypiperidine
Racemic piperidin-3-ol
rac-3-hydroxy-piperidine
PIPERIDOLATE_met022
(r,s)-3-hydroxypiperidine
3-(r,s)-hydroxypiperidine
UH54C3N4VL
SCHEMBL10884
3-Piperidinol, (+/-)-
CHEMBL22463
3-piperidinemethanolhydrochloride
3-Hydroxypiperidine, (+/-)-
DTXSID70870212
BCP05289
AKOS000120490
AKOS016842335
CS-W013706
FH00454
PB25197
PB26394
PB27381
SB10195
3-Hydroxypiperidine, >=98.0% (NT)
AC-26297
AS-38667
SY223959
SY223992
DB-003056
A7210
H0412
NS00045695
EN300-20284
F2158-0911
Z104477592