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4-Piperidone

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Identification
Molecular formula
C5H9NO
CAS number
41661-47-6
IUPAC name
piperidin-4-one
State
State
At room temperature, 4-Piperidone may exist in a liquid or solid crystalline form depending on the ambient conditions and purity.
Melting point (Celsius)
28.00
Melting point (Kelvin)
301.00
Boiling point (Celsius)
233.00
Boiling point (Kelvin)
506.00
General information
Molecular weight
99.14g/mol
Molar mass
99.1420g/mol
Density
1.0065g/cm3
Appearence

4-Piperidone typically appears as a colorless to pale yellow liquid or solid. It is often present in the form of a crystalline powder if solid, with characteristic piperidine aroma.

Comment on solubility

Solubility of Piperidin-4-one

Piperidin-4-one, with the chemical formula C5H9NO, displays interesting solubility characteristics that are important for various applications. Understanding its behavior in different solvents enhances our insight into its usage in both laboratory and industrial settings.

Solubility Characteristics:

  • Polar solvents: Piperidin-4-one is known to be soluble in water due to the presence of the carbonyl group that can form hydrogen bonds with water molecules.
  • Non-polar solvents: The compound is also soluble in many organic solvents such as alcohols, chloroform, and ether, which is attributed to its alkyl and nitrogen components.
  • Temperature effects: Solubility can vary with temperature; generally, increased temperatures enhance the solubility of piperidin-4-one in both polar and non-polar solvents.

In summary, the solubility of piperidin-4-one can be classified as high in polar solvents and moderate to high in non-polar solvents, making it a versatile compound in synthetic organic chemistry. Its ability to dissolve in a range of solvents underscores its utility in various chemical reactions and processes.

Interesting facts

Interesting Facts about Piperidin-4-one

Piperidin-4-one is a fascinating compound that plays a significant role in the field of organic chemistry and medicinal chemistry. Here are some key points to consider:

  • Structural Importance: Piperidin-4-one contains a piperidine ring, which is a six-membered saturated ring with a nitrogen atom. This unique structure is pivotal in the development of various pharmaceuticals and biologically active compounds.
  • Versatile Intermediate: The compound serves as an essential building block for synthesizing more complex molecules. It can be used to create various derivatives that may exhibit diverse biological activities.
  • Biological Relevance: Several derivatives of piperidin-4-one have been investigated for their potential as therapeutic agents, especially in treating neurological disorders, thanks to their ability to interact with various receptors in the brain.
  • Role in Synthesis: Piperidin-4-one is often used in the synthesis of compounds like antihypertensives and other drug classes, indicating its significance in drug discovery and development processes.
  • Literature Presence: The compound has been referenced and studied extensively in scientific literature, highlighting its relevance and applications across various research domains.

As with many organic compounds, the study of piperidin-4-one unveils the complexities of chemical interactions and the endless possibilities for innovation in pharmaceutical design. In the words of chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." Piperidin-4-one undoubtedly embodies this spirit of discovery!

Synonyms
4-Piperidone
4-Piperidinone
15WP1EA7UH
EINECS 255-481-1
UNII-15WP1EA7UH
.GAMMA.-PIPERIDINONE
DTXSID50194488
GAMMA-PIPERIDINONE
RefChem:100408
DTXCID60116979
255-481-1
4-piperidone (piperidin-4-one), its acetals, its amides, its carbamates, its salts, and salts of its acetals, its amides, and its carbamates, and any combination thereof, whenever the existence of such is possible.
VRJHQPZVIGNGMX-UHFFFAOYSA-N
piperidin-4-one
41661-47-6
4-oxopiperidine
4piperidone
4-oxo-piperidine
piperid-4-one
4-Piperidone, AldrichCPR
SCHEMBL5376
SCHEMBL83334
SCHEMBL3102511
SCHEMBL3109296
SCHEMBL8125294
SCHEMBL20183688
BCP15157
STR10461
MFCD00955709
STK501631
AKOS005170706
4-PIPERIDINON(monohydrate hydrochloride)
PD057831
DB-006899
CS-0053778
NS00031030
ST45174805
EN300-34087
Q3401775