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1-Piperidinecarboxaldehyde

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Identification
Molecular formula
C6H11NO
CAS number
1604-29-9
IUPAC name
piperidine-1-carbaldehyde
State
State

State: Liquid at room temperature.

Melting point (Celsius)
-57.90
Melting point (Kelvin)
215.25
Boiling point (Celsius)
171.10
Boiling point (Kelvin)
444.25
General information
Molecular weight
99.15g/mol
Molar mass
99.1480g/mol
Density
0.9960g/cm3
Appearence

1-Piperidinecarboxaldehyde is a colorless to pale yellow liquid. It may darken over time when exposed to air or light.

Comment on solubility

Solubility of Piperidine-1-carbaldehyde

Piperidine-1-carbaldehyde, with the chemical formula C6H11NO, is a versatile compound notable for its unique solubility properties. The solubility of this compound is influenced by several factors:

  • Polarity: The presence of the aldehyde functional group contributes to its polar nature, enhancing its solubility in polar solvents.
  • Solvent Interaction: Piperidine-1-carbaldehyde is generally soluble in water and other polar solvents, such as ethanol and methanol. This makes it useful in various chemical reactions.
  • Temperature Effects: Solubility can also depend on temperature—higher temperatures typically increase solubility in most solvents.

As a liquid at room temperature, it is also noteworthy that:

  • It is immiscible in nonpolar solvents like hexane and benzene, which limits its application in nonpolar environments.
  • Its solubility in aqueous solutions provides a pathway for potential interactions in biological systems.

In conclusion, the solubility profile of piperidine-1-carbaldehyde is a critical aspect to consider when working with this compound, especially in synthesis and formulation contexts. As stated, “Understanding solubility is key to unlocking chemical reactivity and bioavailability.

Interesting facts

Interesting Facts about Piperidine-1-carbaldehyde

Piperidine-1-carbaldehyde is a fascinating organic compound that belongs to the class of aldehydes. Known for its unique structure and chemical properties, it serves as an important intermediate in various chemical syntheses.

Chemical Structure & Properties

One of the standout features of piperidine-1-carbaldehyde is its piperidine ring, a six-membered heterocyclic compound containing one nitrogen atom. This ring structure contributes to its reactive aldehyde functional group, making it highly versatile in chemical reactions. Some properties that highlight its significance include:

  • Intermediate in Synthesis: It is commonly used as a building block in the pharmaceutical industry, aiding in the synthesis of various biologically active compounds.
  • Potential Biological Activity: Esters and derivatives of this compound have shown promising activity in medicinal chemistry, with potential applications in drug development.
  • Reactivity: The aldehyde group allows for easy modifications, facilitating the creation of complex molecules needed in various research fields.

Applications and Uses

Piperidine-1-carbaldehyde boasts a wide range of applications, making it a valuable compound for chemists:

  • Pharmaceuticals: It serves as a precursor in the synthesis of various pharmaceuticals, contributing to the development of new therapeutic agents.
  • Agrochemicals: This compound is also used in the production of agrochemicals, playing a role in crop protection and enhancement.
  • Chemical Research: As a reagent, it is utilized in various reactions, including the synthesis of nitrogen-containing compounds.

In conclusion, piperidine-1-carbaldehyde is much more than just a chemical compound; it is a pivotal player in the world of organic synthesis and medicinal chemistry. Its unique properties and versatility open up exciting possibilities in research and industrial applications, making it an intriguing subject of study for both students and seasoned chemists alike.

Synonyms
N-Formylpiperidine
2591-86-8
1-Formylpiperidine
1-Piperidinecarboxaldehyde
Formylpiperidine
Piperidinoformamide
N-Formylpiperidin
Piperidine-N-carbaldehyde
PIPERIDINE, 1-FORMYL-
N-Piperidinecarboxaldehyde
N-Formylpiperidin [German]
N-Carbaldehyde piperidine
ZIQ29H6CZG
NSC 1066
EINECS 219-986-0
NSC 404158
DTXSID8043941
FORMYLPIPERIDIDE
AI3-15238
NSC-1066
NSC-404158
DTXCID6023941
N-Formylpiperidin (german)
piperidine-1-carbaldehyde
1-Piperidinecarbaldehyde
Piperidine-1-carboxaldehyde
1-formyl-piperidine
MFCD00006483
WLN: T6NTJ AVH
FPI
N-Formyl piperdine
1-Formyl piperidine
UNII-ZIQ29H6CZG
n-formylpiperdine
Formyl piperidine
N- formylpiperidine
N-formyl piperidine
N-formyl-piperidine
piperidinecarboxaldehyde
1-Formylpiperidine, 99%
1-Piperidinecarbaldehyde #
SCHEMBL2638
CHEMBL1232817
NSC1066
CHEBI:193610
BCP20086
Tox21_302107
NSC404158
AKOS000297086
CS-W016610
DB04113
SB42936
NCGC00255934-01
PS-11953
CAS-2591-86-8
DB-004071
F0234
NS00003291
D77795
EN300-133690
A833967
Q6951369
F1984-0370
Z1255415437
InChI=1/C6H11NO/c8-6-7-4-2-1-3-5-7/h6H,1-5H