Skip to main content

Pipecolic acid

ADVERTISEMENT
Identification
Molecular formula
C6H11NO2
CAS number
535-75-1
IUPAC name
piperidine-2-carboxylic acid
State
State

At room temperature, pipecolic acid is a solid compound. It is stable under normal conditions and should be stored in a dry place, away from moisture to prevent caking or degradation of its crystalline structure.

Melting point (Celsius)
256.00
Melting point (Kelvin)
529.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
129.16g/mol
Molar mass
129.1610g/mol
Density
1.2844g/cm3
Appearence

Pipecolic acid appears as a white to off-white crystalline powder. It is typically odorless, and its crystalline form may vary with humidity and temperature. When viewed under a microscope, it shows a distinct crystal shape typical of amino acids.

Comment on solubility

Solubility of Piperidine-2-carboxylic Acid

Piperidine-2-carboxylic acid, with the chemical formula C6H11NO2, exhibits interesting solubility characteristics that are notable for various applications in chemistry and biochemistry.

Solubility Characteristics:

  • Polar Solvent Interaction: This compound is soluble in polar solvents due to the presence of the carboxylic acid group, which can form hydrogen bonds with water.
  • Limited Solubility in Nonpolar Solvents: It shows poor solubility in nonpolar solvents such as hydrocarbons, which is typical for compounds containing polar functional groups.
  • Temperature Influence: Solubility can generally increase with temperature, an important factor for experimental procedures in labs.

As a result, piperidine-2-carboxylic acid is often utilized in an aqueous environment, enhancing its reactivity and interactions in systems where solubility is crucial. This characteristic makes it a valuable compound in both synthetic and medicinal chemistry.

Interesting facts

Interesting Facts about Piperidine-2-carboxylic Acid

Piperidine-2-carboxylic acid is a fascinating compound that holds a unique position in the world of organic chemistry. Here are some intriguing aspects of this compound:

  • Structural Characteristics: The presence of a piperidine ring—a six-membered saturated nitrogen-containing heterocycle—gives this compound notable cyclic properties. This structure is not only interesting from a synthetic perspective but also influences its reactivity and biological activities.
  • Biological Importance: Piperidine-2-carboxylic acid serves as a building block for various pharmaceuticals. Its derivatives have been studied for their potential in treating neurological disorders, showcasing its importance in medicinal chemistry.
  • Synthesis Routes: The synthesis of piperidine-2-carboxylic acid often involves the modification of piperidine rings or the use of novel methods such as cyclizations, making it a subject of interest for organic synthetic chemists.
  • Applications Beyond Medicine: Apart from its pharmaceutical applications, this compound is utilized in the production of agrochemicals and can serve as an intermediate in various organic reactions, highlighting its versatility.
  • Fascinating Derivatives: The chemical can lead to numerous derivatives with different functional groups, which can alter its properties significantly and create compounds with varying biological activities.
  • Research and Development: Ongoing research on piperidine-2-carboxylic acid aims to unlock new pathways for drug latching, making it a promising compound for future medicinal discoveries.

As scientists delve into the unique properties of piperidine-2-carboxylic acid, they continue to uncover its potential and versatility. Its role in shaping organic chemistry and medicinal applications cannot be overstated, making it a compound worthy of study in both academic and industrial settings.

Synonyms
piperidine-2-carboxylic acid
DL-Pipecolinic acid
535-75-1
Pipecolic acid
Pipecolinic acid
2-PIPERIDINECARBOXYLIC ACID
4043-87-2
DL-Pipecolic acid
pipecolate
Dihydrobaikiane
Piperolinic acid
L-PipecolicAcid
Hexahydropicolinic acid
Acide pipecolique
2-Carboxypiperidine
l(-)-pipecolinic acid
DL-Homoproline
MFCD00064347
(+/-)-Pipecolic acid
(R)-(+)-2-Piperidinecarboxylic acid
2-Pipecolinic acid
Hexahydro-2-picolinic acid
Acide pipecolique [French]
Acide piperidine-carboxylique-2
(+/-)-Pipecolinic acid
(+/-)-2-Piperidinecarboxylic Acid
83680-83-5
EINECS 208-616-3
EINECS 223-737-1
H254GW7PVV
NSC 17125
Acide piperidine-carboxylique-2 [French]
CHEBI:17964
.alpha.-Pipecolinic acid
NSC-17125
2-Piperidinecarboxylic acidd
PIPECOLIC ACID [MI]
piperidine-6-carboxylic acid
DTXSID40862144
2-Pyridine(carboxylic acid-13C1)
PIPECOLIC ACID DL-FORM [MI]
(+/-)-Piperidine-2-carboxylic acid
Pipecolic acid, L-
Pipecolic acid, (S)-(-)-
2-Piperidinecarboxylic acid, (S)-
MFCD00005981
homopipecolic acid
UNII-H254GW7PVV
Pipecolinate
Pipecolinicacid
Piperolinate
a-Pipecolinate
DL-Pipecolinate
DL-Pipecolate
MFCD00064346
pipecolic acid, (+,-)-isomer
alpha-Pipecolinate
Hexahydropicolinate
a-Pipecolinic acid
(+/-)-Pipecolate
alpha-Pipecolinic acid
(+/-)-Pipecolinate
2-Piperidinecarboxylate
Hexahydro-2-picolinate
Pipecolic acid free base
(+/-) pipecolic acid
Pipecolinic acid, 98%
DL-2-Piperidinecarboxylate
2-Piperidinylcarboxylic acid
2-piperidine carboxylic acid
2-piperidine-carboxylic acid
NCIOpen2_001582
SCHEMBL22016
(RS)-2-Piperidinecarboxylate
2-Piperidinecarboxylic acid #
PIPECOLIC ACID DL-FORM
dl-2-piperidinecarboxylic acid
CHEMBL308408
(+,-)-PIPECOLIC ACID
(+/-)-2-Piperidinecarboxylate
HXEACLLIILLPRG-UHFFFAOYSA-
rac piperidine-2-carboxylic acid
()-Piperidine-2-carboxylic acid
DTXCID70810951
(RS)-2-Piperidinecarboxylic acid
CS-B1313
HY-Y0669
NSC17125
NSC93089
AC-691
s6322
STL183326
AKOS000120345
AKOS016050399
(.+/-.)-2-Piperidinecarboxylic acid
2-Piperidinecarboxylic acid, (+/-)-
AB00554
AC-2835
FP34562
PS-5851
2-Piperidinecarboxylic acid, (A+/-)-
2-Piperidinecarboxylic acid, (.+/-.)-
SY002975
SY003075
SY003076
DB-038159
NS00074152
P0442
EN300-20680
Q7197255
F2191-0193
Z104479780
D(+)-Pipecolinic acid; (R)-(+)-2-Piperidinecarboxylic acid
InChI=1/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)
208-616-3