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Piperidine-3-carboxylic acid

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Identification
Molecular formula
C6H11NO2
CAS number
498-95-3
IUPAC name
piperidine-3-carboxylic acid
State
State

At room temperature, piperidine-3-carboxylic acid is in a solid state. It features a relatively stable, crystalline structure.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
344.00
Boiling point (Kelvin)
617.15
General information
Molecular weight
129.16g/mol
Molar mass
129.1580g/mol
Density
1.1903g/cm3
Appearence

Piperidine-3-carboxylic acid is a colorless to white crystalline solid. It typically appears as powder or crystalline pieces.

Comment on solubility

Solubility of Piperidine-3-carboxylic Acid (C6H11NO2)

Piperidine-3-carboxylic acid is an intriguing compound when it comes to solubility characteristics. Its solubility is influenced by several factors, including pH, temperature, and the nature of the solvent used. Here are some key points to consider:

  • Aqueous Solubility: Piperidine-3-carboxylic acid exhibits moderate solubility in water, mainly due to the presence of the carboxylic acid group.
  • Organic Solvents: It tends to be more soluble in polar organic solvents such as methanol and ethanol, which can also stabilize the ionic form of the compound.
  • pH Dependency: Solubility can vary with pH; in more acidic conditions, the carboxylic group can remain protonated, affecting its dissociation and, consequently, its solubility.
  • Temperature Effects: An increase in temperature generally enhances solubility, allowing for greater interactions between the compound and solvent molecules.

As a general observation, the solubility of piperidine-3-carboxylic acid makes it a useful compound in various chemical applications, allowing it to react in several environments due to its moderate polarity and solvation properties. Its ability to dissolve in different media enhances its versatility in synthesis and research.

Interesting facts

Interesting Facts about Piperidine-3-Carboxylic Acid

Piperidine-3-carboxylic acid is a fascinating compound that belongs to the class of cyclic amines, specifically a derivative of piperidine. This versatile molecule is of significant interest in both the pharmaceutical and organic chemistry domains. Here are some key highlights about this compound:

  • Structural Insight: The unique structure of piperidine-3-carboxylic acid features a six-membered ring with a carboxylic acid group attached at the third carbon. This structure plays a crucial role in its reactivity and biological properties.
  • Pharmaceutical Applications: Due to its structural characteristics, piperidine-3-carboxylic acid serves as a building block in the synthesis of various pharmaceuticals, particularly in the development of neuroactive drugs.
  • Biological Relevance: Researchers often explore its potential as a scaffold for designing selective inhibitors in medicinal chemistry, making it a valuable compound in drug discovery processes.
  • Versatile Intermediate: Piperidine-based carboxylic acids can be utilized as intermediates in the synthesis of agrochemicals and fine chemicals, underscoring their broad utility in industrial applications.
  • Chirality: With its potential for stereochemistry, piperidine-3-carboxylic acid can exist in different enantiomeric forms, leading to variations in its biological activity and interactions.

As noted by a prominent chemist, “The synthesis of compounds like piperidine-3-carboxylic acid exemplifies the intricate relationship between structure and function in organic chemistry.” This compound not only enriches the tapestry of synthetic organic chemistry but also paves the way for innovation in drug design and molecular biology.

In summary, piperidine-3-carboxylic acid stands out as a compound with considerable implications in scientific research, carrying the potential to influence the development of new therapeutic agents.

Synonyms
nipecotic acid
Piperidine-3-carboxylic acid
498-95-3
3-Piperidinecarboxylic acid
(+/-)-Nipecotic acid
h-dl-nip-oh
hexahydronicotinic acid
60252-41-7
dl-nipecotic acid
MFCD00005992
3-carboxypiperidine
(+/-)-beta-Homoproline
EINECS 207-873-9
1U1QTN40SY
CHEBI:116931
NIPECOTIC ACID [MI]
CHEMBL277498
DTXSID00870568
(+/-)-.BETA.-HOMOPROLINE
SR-01000075612
UNII-1U1QTN40SY
Nipecotic
MFCD01630787
(y)-Nipecotic acid
(?)-Nipecotic acid
(RS)-nipecotic acid
Nipecotic acid, 98%
Spectrum_000353
Prestwick0_000950
Prestwick1_000950
Prestwick2_000950
Prestwick3_000950
Spectrum2_001184
Spectrum3_001712
Spectrum4_000169
Spectrum5_001412
(A+/-)-Nipecotic acid
3-aPiperidinecarboxylic acid
3-piperidine carboxylic acid
Lopac0_000041
SCHEMBL85677
BSPBio_000920
BSPBio_003324
KBioGR_000657
KBioSS_000833
MLS000069598
DivK1c_000148
SPECTRUM2300345
SPBio_001227
SPBio_003079
BPBio1_001012
GTPL4564
HMS500H10
KBio1_000148
KBio2_000833
KBio2_003401
KBio2_005969
KBio3_002544
DTXCID10818279
NINDS_000148
HMS1570N22
HMS2097N22
HMS2235L11
HMS3260I03
Tox21_500041
BDBM50003624
CCG-40009
PDSP1_000143
PDSP2_000142
STL193988
AKOS000120441
AKOS016347225
AC-2538
CS-W020556
FN02349
LP00041
PB29158
PB30681
PS-6088
SB10229
SB41071
SDCCGSBI-0050030.P003
IDI1_000148
MLS-0072915
NIPECOTIC ACID, (+/-)-ISOMER
( inverted question mark)-Nipecotic acid
[J Neurochem 25: 797 (1975)
NCGC00014992-03
NCGC00014992-04
NCGC00014992-05
NCGC00014992-06
NCGC00014992-07
NCGC00014992-08
NCGC00014992-14
NCGC00024510-02
NCGC00024510-03
NCGC00024510-04
NCGC00024510-05
NCGC00260726-01
HY-69359
SMR000059031
SY001864
SY009080
SY018213
MLS-0072915.P019
DB-022674
DB-218188
AB00052417
EU-0100041
N0420
NS00015522
Piperidine-3-carboxylic acid(nipecotic acid)
EN300-17207
SR-01000075612-1
SR-01000075612-2
Q11324593
( inverted question mark)-3-Piperidine carboxylic acid
F0001-1300
Nipecotic acid;Piperidine-3-carboxylic acid;L-nipecotic acid
207-873-9