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Piperidine-4-carboxylic acid hydrochloride

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Identification
Molecular formula
C6H11NO2·HCl
CAS number
1008-71-3
IUPAC name
piperidine-4-carboxylic acid;hydrochloride
State
State

Piperidine-4-carboxylic acid hydrochloride is typically in a solid state at room temperature. It is usually encountered as a crystalline powder.

Melting point (Celsius)
294.50
Melting point (Kelvin)
567.65
Boiling point (Celsius)
170.00
Boiling point (Kelvin)
443.15
General information
Molecular weight
169.61g/mol
Molar mass
169.6130g/mol
Density
1.3500g/cm3
Appearence

Piperidine-4-carboxylic acid hydrochloride typically appears as a white to off-white crystalline powder. It is hygroscopic and can absorb moisture from the environment.

Comment on solubility

Solubility of Piperidine-4-Carboxylic Acid; Hydrochloride

Piperidine-4-carboxylic acid; hydrochloride, a salt form of a cyclic amine derivative, exhibits notable solubility characteristics that are important for its applications. This compound is generally considered to be highly soluble in water, which is a significant trait for substances used in pharmaceuticals and biochemical applications. The solubility can be attributed to the presence of the hydrochloride salt which enhances its ionization in aqueous solutions.

  • Water Solubility: The presence of the carboxylic acid group allows it to interact favorably with water molecules.
  • Alcohol Solubility: Solubility in lower alcohols is also notable due to similar polar characteristics.
  • Solvent Effects: The solubility may vary in other solvents, with non-polar solvents showing significantly reduced solvation.

As with many amino acids and their derivatives, the ionic nature of the hydrochloride form further facilitates dissolution in polar solvents, making the compound readily available for various chemical reactions. In practical contexts, this high level of solubility plays a crucial role in both reaction kinetics and bioavailability of the compound in biological systems.

Interesting facts

Interesting Facts about Piperidine-4-Carboxylic Acid; Hydrochloride

Piperidine-4-carboxylic acid; hydrochloride is a fascinating compound within the realm of organic chemistry. Here are some key highlights that showcase its significance and utility:

  • Structural Significance: This compound features a piperidine ring, a six-membered alicyclic amine, which is crucial in many biological systems. The carboxylic acid functionality located at the 4-position enhances its reactivity and versatility.
  • Pharmaceutical Relevance: Due to its unique structure, piperidine derivatives are often found in pharmaceutical applications. Many compounds derived from piperidine are used as medications, exhibiting a range of biological activities, including analgesic, anti-inflammatory, and antidepressant effects.
  • Utility in Synthesis: The carboxylic acid group in this compound acts as an excellent precursor for various synthetic transformations, making it valuable in the development of complex organic molecules.
  • Research Applications: Piperidine-4-carboxylic acid; hydrochloride is frequently utilized in academic research and pharmaceutical development, particularly in the study of neuroactive compounds and molecular modeling.

In the words of a renowned chemist, "The beauty of organic chemistry lies in understanding how simple structures can give rise to complex biological phenomena." This compound exemplifies that beauty through its intricate interactions in various chemical environments.

Overall, piperidine-4-carboxylic acid; hydrochloride serves as a valuable tool in both theoretical research and practical applications across multiple fields of science!

Synonyms
5984-56-5
Isonipecotic acid hydrochloride
4-Piperidinecarboxylic acid, hydrochloride
Isonipecotic acid, hydrochloride
4-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
9Y7QNE4DH3
Isonipecotic acid hydrochloride [MI]
4-Piperidinecarboxylic acid, hydrochloride (1:1)
DTXSID00208564
DTXCID50131055
611-901-9
piperidine-4-carboxylic acid hydrochloride
Piperidine-4-carboxylic acid, HCl
piperidine-4-carboxylic acid;hydrochloride
UNII-9Y7QNE4DH3
MFCD00044736
SCHEMBL1703706
NVUYWKBRSRPYMH-UHFFFAOYSA-N
AKOS015897807
piperidine-4-carboxylicacidhydrochloride
SB10228
PIPERIDINE-4-CARBOXYLIC ACID HCL
TS-02226
DB-053473
CS-0054434
NS00034251
O12044
Q27273381
F0001-1572