Skip to main content

Nitrazepam

ADVERTISEMENT
Identification
Molecular formula
C15H11N3O3K
CAS number
146-22-5
IUPAC name
potassium;7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylate
State
State

At room temperature, Nitrazepam is typically in a solid state.

Melting point (Celsius)
227.00
Melting point (Kelvin)
500.15
Boiling point (Celsius)
428.00
Boiling point (Kelvin)
701.15
General information
Molecular weight
282.72g/mol
Molar mass
282.7190g/mol
Density
1.5000g/cm3
Appearence

Nitrazepam appears as a white to yellow crystalline powder. It may have a mild benzodiazepine odor.

Comment on solubility

Solubility of Potassium 7-Nitro-2-Oxo-5-Phenyl-1,3-Dihydro-1,4-Benzodiazepine-3-Carboxylate

The solubility of potassium 7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylate is influenced by several key factors. Understanding these factors is essential for its practical applications in pharmaceuticals and research:

  • Polarity: The compound contains multiple functional groups that may affect its overall polarity. Compounds with a higher degree of polarity tend to have better solubility in polar solvents such as water.
  • Hydrogen bonding: If the compound can participate in hydrogen bonding, it will have increased solubility in protic solvents. The carboxylate group may contribute to this phenomenon.
  • Ionization: Being a carboxylate compound, the ionization state can significantly impact solubility. For example, at varying pH levels, the ionization of the carboxylate group will dictate its solubility:
    • At low pH, the carboxylic acid may be protonated, leading to lower solubility.
    • At neutral or high pH, the deprotonated carboxylate increases solubility.
  • Temperature: Generally, increased temperature enhances solubility. However, this can vary based on the specific compound and solvent.

In conclusion, while potassium 7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylate may exhibit variable solubility depending on the solvent system and environmental conditions, optimizing these factors can lead to enhanced dissolution and improved bioavailability in medicinal applications. Understanding the solubility profile is crucial for its effectiveness and utility in research and development.

Interesting facts

Interesting Facts About Potassium; 7-Nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylate

The compound known as potassium; 7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylate is a fascinating example of a hybrid structure that combines elements of both organic chemistry and pharmacology. This compound belongs to the benzodiazepine family, well-known for their calming, anti-anxiety properties.

Chemical Structure and Properties

  • Benzodiazepine Core: The compound features a benzodiazepine core, which is crucial for its interaction with the central nervous system.
  • Nitro Group: The presence of a nitro group at the 7-position significantly influences the compound's potency and efficacy.
  • Carboxylate Moiety: The carboxylate group not only contributes to the compound’s solubility characteristics but also plays a key role in its biological activity.

Biological Significance

This compound is particularly captivating due to its potential applications in medicine. Research suggests that derivatives of benzodiazepines could:

  • Act as Anxiolytics: Help reduce anxiety symptoms.
  • Have Sedative Effects: Serve as sedatives for individuals undergoing stressful medical procedures.
  • Possess Anticonvulsant Properties: Be effective in managing seizures in epilepsy patients.

Research and Development

Scientists continue to explore the benefits and applications of such compounds in the pharmaceutical industry. As noted by chemists, "The future of benzodiazepines lies in the modification of their structures to enhance efficacy and reduce side effects." The journey of compounds like potassium; 7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylate illustrates the intricate relationship between structure and function in drug design.

In conclusion, the exploration of potassium; 7-nitro-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxylate opens new avenues for understanding and potentially treating a wide range of neurological disorders, showcasing the importance of interdisciplinary approaches in modern chemistry.

Synonyms
Potassium nitrazepate
Potassium nitrazepate [INN]
Kalii nitrazepas
Nitrazepate de potassium
Monopotassium nitrazepate
Nitrazepato potasico
Nitrazipato potasico
Kalii nitrazepas [INN-Latin]
Nitrazepate de potassium [INN-French]
Nitrazipate de potassium
Nitrazepato potasico [INN-Spanish]
Nitrazipato potasico [INN-Spanish]
Nitrazipate de potassium [INN-French]
UNII-3D69H48U8Q
4336 CB
nitrazepato de potasio
5571-84-6
3D69H48U8Q
1H-1,4-Benzodiazepine-3-carboxylic acid, 2,3-dihydro-7-nitro-2-oxo-5-phenyl-, monopotassium salt
4335 C. B.
Kalii nitrazepas (INN-Latin)
Nitrazepato potasico (INN-Spanish)
Nitrazipato potasico (INN-Spanish)
Nitrazepate de potassium (INN-French)
Nitrazipate de potassium (INN-French)
nitrazApate (acid)
1h-1,4-benzodiazepine-3-carboxylic acid, 2,3-dihydro-7-nitro-2-oxo-5-phenyl-, potassium salt
potassium nitrazepate [who-dd]
SCHEMBL2734205
CHEMBL2104581
Potassium 2,3-dihydro-7-nitro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate
Q15409364