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Propylparaben

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Identification
Molecular formula
C10H12O3
CAS number
94-13-3
IUPAC name
propyl 4-hydroxybenzoate
State
State

At room temperature, propylparaben is in a solid state.

Melting point (Celsius)
96.00
Melting point (Kelvin)
369.15
Boiling point (Celsius)
297.00
Boiling point (Kelvin)
570.15
General information
Molecular weight
180.20g/mol
Molar mass
180.1990g/mol
Density
1.0630g/cm3
Appearence

Propylparaben is a white crystalline, odorless solid. It is often available in powder form and is known for being an effective preservative with antibacterial and antifungal properties.

Comment on solubility

Solubility of Propyl 4-Hydroxybenzoate

Propyl 4-hydroxybenzoate, commonly known as propyl paraben, exhibits a varied solubility profile that is noteworthy in both aqueous and organic solvents. Here’s what you need to know:

  • Aqueous Solubility: Propyl 4-hydroxybenzoate is poorly soluble in water. Its low solubility can be attributed to its hydrophobic alkyl chain which inhibits interaction with water molecules.
  • Organic Solvent Solubility: In contrast, this compound is readily soluble in organic solvents such as ethanol, methanol, and other non-polar solvents, making it particularly useful in formulations where these solvents are used.
  • Temperature Dependence: The solubility of propyl 4-hydroxybenzoate can also be influenced by temperature; typically, increased temperature enhances its solubility in organic solvents.

Overall, the solubility characteristics of propyl 4-hydroxybenzoate suggest it is well-suited for applications in cosmetic and pharmaceutical products where organic solvent use is prevalent. As a rule of thumb, it is important to consider the specific solvent system carefully when formulating products that contain this compound.

Interesting facts

Interesting Facts about Propyl 4-Hydroxybenzoate

Propyl 4-hydroxybenzoate, commonly known as propyl paraben, is a fascinating compound widely utilized in various industries, especially in cosmetics and pharmaceuticals. Here are some intriguing insights:

  • Preservative Properties: Propyl paraben serves as an effective antimicrobial agent, preventing the growth of bacteria and fungi in products. This helps extend the shelf life of formulations, ensuring product efficacy over time.
  • Common Usage: Found in a variety of products, you’ll encounter propyl paraben in items such as shampoos, lotions, and even foods. Its versatility makes it a staple in personal care formulations.
  • Natural Occurrence: Interestingly, parabens, including propyl paraben, are naturally present in several fruits, like blueberries and strawberries, which raises discussions about their safety and natural origins.
  • Regulatory Perspective: Authorities such as the FDA and EFSA have reviewed the safety of propyl paraben, declaring it safe for use in cosmetics and as a food additive at regulated levels.
  • Scientific Research: While widely accepted in various applications, propyl paraben has been the subject of research regarding its endocrine-disrupting potential, prompting discussions about the need for alternatives in formulation.

As environmental and health considerations grow, the role of propyl 4-hydroxybenzoate continues to evolve. In the words of some scientists, "Understanding the compounds we use is crucial for ensuring safety and efficacy in our products." Whether you’re a student embarking on a chemistry journey or an industry professional, awareness of such compounds can enhance your knowledge and application in chemical sciences.

Synonyms
PROPYLPARABEN
Propyl 4-hydroxybenzoate
94-13-3
Propyl paraben
Propyl p-hydroxybenzoate
Nipasol
Nipazol
Propagin
4-Hydroxybenzoic acid propyl ester
Tegosept P
Nipagin P
Propyl parahydroxybenzoate
Chemacide pk
Propyl Parasept
Propyl Butex
Propyl Chemosept
Betacide P
N-Propyl p-hydroxybenzoate
n-Propyl 4-hydroxybenzoate
Propyl aseptoform
Propylparasept
4-Hydroxybenzoic acid, propyl ester
Chemocide pk
Aseptoform P
p-Hydroxypropyl benzoate
Betacine P
Protaben P
Nipasol P
Solbrol P
p-Hydroxybenzoic acid propyl ester
Paseptol
p-Hydroxybenzoic propyl ester
Preserval P
n-propyl paraben
Bonomold OP
Nipasol M
Propyl-4-hydroxybenzoate
N-Propylparaben
FEMA No. 2951
Propyl chemsept
Propyl-paraben
Caswell No. 714
Paratexin p
Benzoic acid, 4-hydroxy-, propyl ester
Paraben p
Bayer D 206
FEMA Number 2951
propyl para-hydroxybenzoate
Benzoic acid, p-hydroxy-, propyl ester
Propylparaben e216
propyl hydroxybenzoate
HSDB 203
UNII-Z8IX2SC1OH
Chemoside PK
Lexgard P
p-Oxybenzoesaurepropylester
Pulvis conservans
Z8IX2SC1OH
NSC-8511
p-Hydroxybenzoic acid, propyl ester
EINECS 202-307-7
MFCD00002354
NSC 23515
NSC-23515
EPA Pesticide Chemical Code 061203
BRN 1103245
DTXSID4022527
CHEBI:32063
n-PROPYL-p-HYDROXYBENZOATE
Propylis hydroxybenzoas
AI3-01341
propyl 4-oxidanylbenzoate
Propylester kyseliny p-hydroxybenzoove
p-Oxybenzoesaeurepropylester
MLS002152934
DTXCID602527
EC 202-307-7
4-Hydroxybenzoic acid-propyl ester
PROPYL (4-HYDROXYBENZOATE)
4-10-00-00374 (Beilstein Handbook Reference)
NSC23515
p-Hydroxybenzoic acid n-propyl ester
NCGC00090965-03
NCGC00090965-04
SMR000112070
PROPYLPARABEN (II)
PROPYLPARABEN [II]
WLN: QR DVO3
Propyl parahydroxybenzoate;Propyl 4-hydroxybenzoate
PROPYLPARABEN (USP-RS)
PROPYLPARABEN [USP-RS]
Propylparaben [USAN]
Propyl 4-hydroxybenzoate, >=99%
Pulvis conservans (VAN)
4-Hydroxybenzoic acid-propyl ester 1000 microg/mL in Acetonitrile
PROPYL HYDROXYBENZOATE (MART.)
PROPYL HYDROXYBENZOATE [MART.]
CAS-94-13-3
Propyl 4-?Hydroxybenzoate(Propyl Paraben)
PEPH
PROPYL PARAHYDROXYBENZOATE (EP IMPURITY)
PROPYL PARAHYDROXYBENZOATE [EP IMPURITY]
PROPYL PARAHYDROXYBENZOATE (EP MONOGRAPH)
PROPYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
85403-59-4
p-Oxybenzoesaurepropylester [German]
Propylparaben [USAN:NF]
4-Hydroxybenzoic acid-propyl ester D7 (propyl D7)
METHYL PARAHYDROXYBENZOATE IMPURITY C (EP IMPURITY)
METHYL PARAHYDROXYBENZOATE IMPURITY C [EP IMPURITY]
Propylester kyseliny p-hydroxybenzoove [Czech]
4-Hydroxybenzoic acid propylester
(Propyl Paraben)
36M
propyl p-oxybenzoate
Propylparaben (NF)
Propylparaben, USAN
Propylparaben (Standard)
Propylis parahydroxybenzoas
Propyl 4-?Hydroxybenzoate
SCHEMBL977
n-propyl-4-hydroxybenzoate
PROPYLPARABEN [MI]
PROPYLPARABEN [FCC]
cid_7175
n-propyl-p-hydroxy-benzoate
PROPYLPARABEN [HSDB]
PROPYLPARABEN [VANDF]
MLS002222346
MLS006011654
BIDD:ER0229
PROPYL PARABEN [VANDF]
PROPYLPARABEN [WHO-DD]
CHEMBL194014
Propyl parahydroxybenzoate (TN)
BDBM70190
HY-N2026R
MSK2511
NSC8511
HMS2268K21
Propyl 4-hydroxybenzoate, BioXtra
Propyl parahydroxybenzoate (JP17)
HY-N2026
UYB80267
Tox21_111048
Tox21_400012
BBL023754
s5405
STL294815
4-Hydroxybenzoic acid, n-propyl ester
AKOS008948099
component of Heb-Cort MC (Salt/Mix)
CCG-266432
DB14177
DS-3427
FP63482
PROPYL HYDROXYBENZOATE [WHO-IP]
PROPYL P-HYDROXYBENZOATE [FHFI]
PROPYL PARAHYDROXYBENZOATE [JAN]
USEPA/OPP Pesticide Code: 061203
NCGC00090965-01
NCGC00090965-02
NCGC00090965-05
NCGC00090965-06
NCGC00090965-07
AC-34533
DA-66938
E216
DB-221787
CS-0018518
H0219
NS00002126
P1955
PROPYLIS HYDROXYBENZOAS [WHO-IP LATIN]
D01422
SBI-0653917.0001
EN300-7419478
A844839
Propyl 4-hydroxybenzoate, p.a., 99.0-100.5%
Propyl paraben;4-Hydroxybenzoic acid propyl ester
Propyl Parahydroxybenzoate 0.01 mg/ml in Methanol
Propyl Parahydroxybenzoate 1.0 mg/ml in Methanol
Q511627
BRD-K60783397-001-09-5
Propyl 4-hydroxybenzoate, SAJ first grade, >=98.0%
Propyl 4-hydroxybenzoate, tested according to Ph.Eur.
Propyl 4-hydroxybenzoate, Vetec(TM) reagent grade, 98%
Propylparaben, certified reference material, TraceCERT(R)
Propylparaben, United States Pharmacopeia (USP) Reference Standard
Propyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard
Propylparaben, Pharmaceutical Secondary Standard; Certified Reference Material
202-307-7
InChI=1/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H