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2-Cyanopyridine

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Identification
Molecular formula
C6H4N2
CAS number
100-70-9
IUPAC name
pyridine-2-carbonitrile
State
State

At room temperature, 2-cyanopyridine can exist as a solid crystalline substance, due to its melting point being slightly above room temperature.

Melting point (Celsius)
52.50
Melting point (Kelvin)
325.65
Boiling point (Celsius)
204.00
Boiling point (Kelvin)
477.15
General information
Molecular weight
104.12g/mol
Molar mass
104.1160g/mol
Density
1.1010g/cm3
Appearence

2-Cyanopyridine typically appears as a colorless to pale yellow liquid or crystalline solid. The exact color can vary slightly based on the purity and specific sample. It is also characterized by a distinct smell, often described as mildly pleasant or reminiscent of bitter almonds due to the cyano group.

Comment on solubility

Solubility of Pyridine-2-carbonitrile

Pyridine-2-carbonitrile, also known as 2-cyanopyridine, is an interesting compound with distinct solubility characteristics that can be influenced by several factors. Understanding its solubility is essential for its application in various fields such as pharmaceuticals and organic synthesis. Here are some key points regarding the solubility of pyridine-2-carbonitrile:

  • Solvent Interaction: Pyridine-2-carbonitrile is typically soluble in polar solvents such as water and alcohols due to the presence of its polar cyano group (-C≡N).
  • Hydrogen Bonding: The nitrogen atom in the pyridine ring can engage in hydrogen bonding with water molecules, enhancing its solubility in aqueous solutions.
  • Temperature Dependency: Like many organic compounds, the solubility of pyridine-2-carbonitrile generally increases with temperature, making it more soluble in warm solvents compared to cold ones.
  • Hydrophobic Interactions: Despite its polar nature, the aromatic ring can contribute to hydrophobic interactions, which may limit solubility in highly nonpolar solvents.
  • Concentration Effects: At higher concentrations, solubility may decrease due to the potential for aggregation or the formation of eutectic mixtures.

In summary, pyridine-2-carbonitrile demonstrates a preference for solubility in polar solvents, making it versatile for various chemical applications. As quoted in the field, "the interplay of polarity, temperature, and molecular structure defines solubility." Understanding these principles can lead to better utilization and manipulation of pyridine-2-carbonitrile in scientific endeavors.

Interesting facts

Interesting Facts about Pyridine-2-carbonitrile

Pyridine-2-carbonitrile, also known as 2-cyanopyridine, is an intriguing compound that has garnered attention in various fields of chemistry due to its unique properties and versatile applications. Here are some fascinating insights about this compound:

  • Structure and Reactivity: Pyridine-2-carbonitrile features a pyridine ring substituted with a cyano group. This structural arrangement contributes to its potential as a nucleophile in various organic reactions.
  • Biochemical Importance: The compound is often utilized in the synthesis of biologically active molecules. Its derivatives can exhibit pharmacological properties, making it a valuable building block in medicinal chemistry.
  • Synthetic Pathways: Pyridine-2-carbonitrile can be synthesized through various methods, including the reaction of 2-aminopyridine with cyanogen halides. This versatility in synthesis allows chemists to readily obtain this compound for research and industrial purposes.
  • Applications: This compound finds applications in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and as a ligand in coordination chemistry.
  • Environmental Role: Studies have indicated that pyridine derivatives, including pyridine-2-carbonitrile, can have effects on aquatic ecosystems. Understanding these effects is crucial for assessing environmental risks associated with their use.

In summary, pyridine-2-carbonitrile is not just a simple chemical compound but a molecule with significant relevance in research, industry, and environmental studies. As scientists continue to explore its properties and interactions, the potential applications of this compound may expand even further.

Synonyms
2-Cyanopyridine
Picolinonitrile
100-70-9
Pyridine-2-carbonitrile
2-PYRIDINECARBONITRILE
Pyridinecarbonitrile
2-Pyridyl nitrile
Picolinic acid nitrile
cyanopyridine
2-pyridylnitrile
2-Pyridinecarboxylic acid, nitrile
29386-66-1
WHR1DPG7YS
CHEBI:27837
2-pyridinenitrile
DTXSID9021843
HSDB 5338
2-AZABENZONITRILE
EINECS 202-880-3
2-PYRIDYL CYANIDE
MFCD00006218
NSC 59697
NSC-59697
.ALPHA.-CYANOPYRIDINE
DTXCID101843
CHEMBL3185861
2-PYRIDYL NITRILE [HSDB]
2-cyano pyridine
2-picolinonitrile
CAS-100-70-9
UNII-WHR1DPG7YS
2cyanopyridine
pyridine nitrile
2Pyridyl nitrile
|A-Cyanopyridine
2-cyano-pyridine
alpha-Cyanopyridine
pyridine, 2-cyano-
2-pyridine carbonitrile
Picolinonitrile (8CI)
2-Pyridinecarbonitrile, 99%
SCHEMBL148839
2Pyridinecarboxylic acid, nitrile
BCP25789
NSC59697
Tox21_201343
Tox21_302832
BDBM50622783
STL146673
2-Cyanopyridine 2-Pyridinecarbonitrile
2-cyanopyridine;2-pyridinecarbonitrile
AKOS000119206
AC-2441
CS-W020084
FC74768
FG-0466
NCGC00249029-01
NCGC00256474-01
NCGC00258895-01
BP-12327
BP-24096
SY001165
| inverted exclamation mark-CYANOPYRIDINE
NS00022996
EN300-18317
C02221
D77869
2-Pyridinecarbonitrile, purum, >=98.0% (GC)
Q27103368
F0001-0025
202-880-3