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Nicotinamide

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Identification
Molecular formula
C6H6N2O
CAS number
98-92-0
IUPAC name
pyridine-2-carboxamide
State
State

At room temperature, nicotinamide is in a solid state.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.00
Boiling point (Celsius)
190.00
Boiling point (Kelvin)
463.00
General information
Molecular weight
122.13g/mol
Molar mass
122.1260g/mol
Density
1.4000g/cm3
Appearence

Nicotinamide, also known as niacinamide, appears as a white crystalline powder. It is slightly hygroscopic and has a neutral to slightly acidic taste.

Comment on solubility

Solubility of Pyridine-2-carboxamide

Pyridine-2-carboxamide, also known as 2-Pyridinecarboxamide, is a polar organic compound that exhibits **moderate solubility** in various solvents due to its functional groups. Here are some insights into its solubility characteristics:

  • Water: Pyridine-2-carboxamide shows good solubility in water because the amide group can form hydrogen bonds with water molecules.
  • Alcohols: It is also soluble in alcohols such as methanol and ethanol, again due to hydrogen bonding interactions.
  • Organic Solvents: The compound is soluble in several polar organic solvents, making it versatile for various chemical applications.

In general, the solubility of pyridine-2-carboxamide can be attributed to the presence of both the polar pyridine ring and the amide functional group, allowing for effective interactions with other polar substances. However, it is **insoluble in non-polar solvents** like hexane or benzene due to the lack of sufficient polarity. Thus, the solubility profile of pyridine-2-carboxamide highlights its utility in organic synthesis and biochemical research where polar solvents are often employed.

Interesting facts

Interesting Facts about Pyridine-2-Carboxamide

Pyridine-2-carboxamide, also known as 2-pyridinecarboxamide, is an intriguing compound that belongs to the family of pyridine derivatives. Its unique structure contributes to its diverse applications in various fields:

  • Pharmaceutical Applications: Pyridine-2-carboxamide is often studied for its potential as an active ingredient in pharmaceuticals. Its ability to interact with biological systems makes it valuable in drug design and development.
  • Agricultural Relevance: This compound has been explored for its properties in agrochemicals, showing potential effectiveness as a pesticide or herbicide due to its influence on plant metabolism.
  • Biochemical Importance: Pyridine derivatives, including pyridine-2-carboxamide, play a crucial role in biochemical pathways. They can act as key intermediates in the synthesis of various biosynthetic compounds in living organisms.
  • Research Tool: Due to its chemical properties, pyridine-2-carboxamide has been utilized as a research tool in organic chemistry labs, aiding in the synthesis and study of more complex molecular structures.

As noted by chemist John M. Williams, “The study of pyridine compounds not only enhances our understanding of aromatic chemistry but also broadens the horizon for innovative applications.” This highlights the compound's significance in both academic and industrial research settings.

With its wide-ranging implications, pyridine-2-carboxamide continues to be a subject of interest for scientists seeking to harness its properties for practical applications.

Synonyms
Picolinamide
PYRIDINE-2-CARBOXAMIDE
2-Pyridinecarboxamide
Picolinoylamide
2-Carbamoylpyridine
Picolinic acid amide
2-aminocarbonyl-pyridine
alpha-Picolinamide
.alpha.-Picolinic acid amide
UNII-I3550CCL59
.alpha.-Picolinamide
I3550CCL59
EINECS 215-921-5
NSC 524473
NSC-524473
CHEBI:8200
DTXSID4061703
IBBMAWULFFBRKK-UHFFFAOYSA-
alpha-Picolinic acid amide
PICOLINAMIDE [INCI]
DTXCID5034725
ibbmawulffbrkk-uhfffaoysa-n
inchi=1/c6h6n2o/c7-6(9)5-3-1-2-4-8-5/h1-4h,(h2,7,9)
1452-77-3
2-Picolinamide
MFCD00023483
alpha - picolinamide
Pyridine-2-carboxamide (Picolinamide)
Pyridinecarboxamide
picolamide
pyridine amide
2-picoloylamine
pyridyl carboxamide
Picolinamide, 98%
2-pyridine-carboxamide
pyridine 2-carboxamide
2-picolinic acid amide
Picolinamide (Standard)
pyridine, 2-carbamoyl-
2-pyridinecarboximidic acid
.alpha.-Pyridinecarboxamide
SCHEMBL61183
SCHEMBL11253275
SCHEMBL11256944
pyridine-2-carboxylic acid amide
HMS1784A15
Picolinamide; 2-Pyridinecarboxamide
NSC524473
s4710
AKOS001144712
CCG-266081
FA35338
GS-6464
HY-101020R
SY048638
DB-042775
DB-330527
HY-101020
CS-0020700
NS00024723
P0414
C01950
Q27107933
Z33546380
2-Pyridinecarboxamide; Picolinoylamide; 2-Carbamoylpyridine
WM1