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Picolinic acid

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Identification
Molecular formula
C6H5NO2
CAS number
98-98-6
IUPAC name
pyridine-2-carboxylic acid
State
State

At room temperature, picolinic acid is in the solid state. Its crystalline form is stable, and it is typically encountered as a powder or crystalline solid.

Melting point (Celsius)
136.00
Melting point (Kelvin)
409.15
Boiling point (Celsius)
240.00
Boiling point (Kelvin)
513.15
General information
Molecular weight
123.11g/mol
Molar mass
123.1110g/mol
Density
1.5450g/cm3
Appearence

Picolinic acid appears as a white or slightly off-white crystalline powder. It is relatively odorless and can take the form of needles or plates.

Comment on solubility

Solubility of Pyridine-2-carboxylic Acid (C6H5NO2)

Pyridine-2-carboxylic acid, commonly known as 2-pyridinecarboxylic acid, exhibits interesting solubility characteristics that reflect its molecular structure and polarity.

General Solubility Profile

  • Polar Nature: The presence of both a pyridine ring and a carboxylic acid group contributes to its polar characteristics.
  • Solubility in Water: Pyridine-2-carboxylic acid is moderately soluble in water, largely due to the ability of the carboxylic group to form hydrogen bonds with water molecules.
  • Solvent Compatibility: It is also soluble in a variety of organic solvents such as alcohols, ethers, and chloroform.

Anomalies and Considerations

However, it is essential to consider the following points when discussing its solubility:

  • Temperature Effect: Solubility can vary significantly with temperature. Increased temperature generally enhances solubility in solvents.
  • Concentration Levels: At higher concentrations, solubility can lead to the formation of hydrogen bonds, which may impact its overall solubility profile.
  • pH Influence: The acidity of the solution can also affect the solubility; altering the pH can convert pyridine-2-carboxylic acid into its ionized form, which is typically more soluble in aqueous solutions.

In conclusion, the solubility of pyridine-2-carboxylic acid can be summarized as being moderate in water and variable in organic solvents, influenced by factors such as temperature and pH. This makes it an interesting compound for various chemical applications.

Interesting facts

Interesting Facts about Pyridine-2-carboxylic Acid

Pyridine-2-carboxylic acid, commonly known as 2-pyridinecarboxylic acid or nicotinic acid, is a fascinating compound with a wide array of applications and properties. Here are some noteworthy insights:

  • Biological Importance:
    Pyridine-2-carboxylic acid is an essential component in the synthesis of niacin, a vital nutrient in the vitamin B complex group. Niacin plays a key role in metabolic processes that convert carbohydrates, fats, and proteins into energy.
  • Industrial Applications:
    This compound is extensively utilized in the production of various pharmaceuticals, agricultural chemicals, and food additives. The presence of the pyridine ring enhances its chemical reactivity, making it an ideal precursor for numerous chemical syntheses.
  • Structure Matters:
    The unique structure of pyridine-2-carboxylic acid, featuring both a pyridine ring and a carboxylic acid functional group, contributes to its acidic nature. This property can be attributed to the electron-withdrawing effect of the nitrogen atom in the ring.
  • Research and Development:
    Scientists continue to explore the potential of pyridine-2-carboxylic acid in drug development. Its derivatives are under investigation for applications in treating various conditions, including diabetes and cardiovascular diseases.
  • Environmental Studies:
    Researchers are also studying how this compound interacts in the environment, particularly in the context of organic pollutants. Understanding its behavior can aid in developing methods for bioremediation.

In summary, pyridine-2-carboxylic acid is not just a simple organic compound; it plays a significant role across several domains of science and industry. Its biological relevance, diverse applications, and ongoing research make it a subject of great interest in the field of chemistry.

Synonyms
picolinic acid
98-98-6
2-Picolinic acid
Pyridine-2-carboxylic acid
2-Pyridinecarboxylic acid
2-Carboxypyridine
o-Pyridinecarboxylic acid
alpha-Picolinic acid
Acide picolique
alpha-Pyridinecarboxylic acid
PYRIDINECARBOXYLIC ACID
Pyridine-carboxylique-2
2-pyridine carboxylic acid
MFCD00006293
Acide picolique [French]
NSC 171
Pyridine-carboxylique-2 [French]
2-Picolate
AI3-19242
EINECS 202-719-7
QZV2W997JQ
NSC 21209
BRN 0109595
CCRIS 8307
32075-31-3
DTXSID7031903
CHEBI:28747
PICOLINIC ACID [MI]
Pyridinecarboxylic acid-(2)
CHEMBL72628
.alpha.-Pyridinecarboxylic acid
DTXCID5011903
NSC-171
PCL 016
5-22-02-00003 (Beilstein Handbook Reference)
calcium dipicolinate trihydrate
pyridine, 2-carboxy-
NCGC00165993-01
Nicogamol
Nikogamol
88161-53-9
PLA
CAS-98-98-6
SMR000814709
NSC21209
UNII-QZV2W997JQ
picolinic-acid
picolic acid
2picolinic acid
2Carboxypyridine
2-picolic acid
TOS-BB-0927
A-Picolinic acid
6PC
Pyridinecarboxylique2
oPyridinecarboxylic acid
2pyridinecarboxylic acid
pyridine carboxylic acid
pyridine-carboxylic acid
2-pyridincarboxylic acid
pyridinium 2-carboxylate
a-Pyridinecarboxylic acid
2-pyridine carboxic acid
Pyridine-A-carboxylic acid
2-pyridine-carboxylic Acid
alphaPyridinecarboxylic acid
Oprea1_485360
SCHEMBL36055
MLS001335931
MLS001335932
Picolinic acid (PCL 016)
NSC171
SIOXPEMLGUPBBT-UHFFFAOYSA-
HMS2232K05
BCP26613
CS-D1196
HY-I0660
JLA48761
STR00111
Tox21_112282
Tox21_202953
BDBM50000407
s6249
STL164340
AKOS000119032
Tox21_112282_1
AB00685
AC-2105
FP02239
PS-4253
NCGC00165993-02
NCGC00260499-01
2-Picolinic acid, ReagentPlus(R), 99%
BP-13036
BP-21456
NCI60_001382
SY001169
DB-014967
NS00014903
P0421
EN300-18459
A15945
SBI-0635136.0002
2-Picolinic acid, Vetec(TM) reagent grade, 98%
Q416682
C9DF3EBC-98F0-4165-BE9A-92F8EE33CDBA
BRD-K60612034-001-07-9
BRD-K60612034-001-08-7
Z57968195
F2191-0113
InChI=1/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)
202-719-7