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Isonicotinamide

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Identification
Molecular formula
C6H6N2O
CAS number
1453-82-3
IUPAC name
pyridine-4-carboxamide
State
State

At room temperature, isonicotinamide is in a solid state.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
427.00
Boiling point (Kelvin)
700.15
General information
Molecular weight
122.13g/mol
Molar mass
122.1260g/mol
Density
1.3940g/cm3
Appearence

Isonicotinamide appears as a white crystalline solid.

Comment on solubility

Solubility of Pyridine-4-carboxamide

Pyridine-4-carboxamide, which can also be referred to as 4-pyridinecarboxamide, demonstrates specific solubility characteristics that are influenced by its molecular structure. Overall, the solubility of this compound in different solvents can be summarized as follows:

  • Water: Pyridine-4-carboxamide is moderately soluble in water, thanks to the presence of the carboxamide group that can engage in hydrogen bonding with water molecules.
  • Polar organic solvents: The compound is generally more soluble in polar organic solvents such as ethanol, methanol, and acetone due to similar interactions at the molecular level.
  • Non-polar solvents: Conversely, it shows low solubility in non-polar solvents, as the hydrophobic nature of these solvents limits the dissolution of the polar carboxamide group.

To summarize, the solubility properties of pyridine-4-carboxamide make it a versatile compound in various chemical applications, with its solubility quietly reflecting its functional groups' interactions with different solvents. Remember, as a rule of thumb in chemistry: "like dissolves like".

Interesting facts

Interesting Facts about Pyridine-4-Carboxamide

Pyridine-4-carboxamide, also referred to as 4-pyridinecarboxamide, is an intriguing organic compound that belongs to the class of carboxamides. Its unique structure and properties make it a subject of interest in both academic and industrial settings.

Key Features

  • Pharmaceutical Applications: Pyridine derivatives have been extensively studied for their potential therapeutic uses. Pyridine-4-carboxamide, in particular, has shown promise in drug development due to its biological activity, acting as an important scaffold in medicinal chemistry.
  • Biological Significance: Pyridine compounds are known to participate in various biochemical processes. Some studies suggest that pyridine-4-carboxamide exhibits inhibitory effects on certain enzymes, which could lead to advancements in treatments for diseases.
  • Reaction Versatility: This compound can undergo a variety of chemical reactions, making it a valuable intermediate for synthesizing more complex molecules. Its reactivity includes nucleophilic substitutions and cyclization reactions, which are essential in organic synthesis.

Moreover, its properties allow for exploration in fields such as agrochemistry, where compounds like pyridine-4-carboxamide can be evaluated for their ability to enhance crop protection or plant growth.

Fascinating Anecdote

As one prominent chemist put it, "The versatility of pyridine derivatives is unmatched, making them one of the most employed compounds in organic synthesis." This strong assertion underlines the importance of pyridine-4-carboxamide in advancing chemical research.

In summary, pyridine-4-carboxamide exemplifies the profound relationship between organic chemistry and real-world applications, highlighting the intersection of science, health, and innovation.

Synonyms
Isonicotinamide
4-PYRIDINECARBOXAMIDE
Isonicotineamide
Pyridine-4-carboxylic acid amide
isoniacinamide
gamma-Pyridinecarboxamide
UNII-4H3BH6YX9Q
.gamma.-Pyridinecarboxamide
EINECS 215-926-2
BRN 0002173
CHEBI:6031
DTXSID3020756
4-PICOLINAMIDE
NSC-82353
DTXCID50756
4-(AMINOCARBONYL)PYRIDINE
5-22-02-00195 (Beilstein Handbook Reference)
NSC 82353
ISONIAZID IMPURITY B [EP IMPURITY]
ISONIAZID IMPURITY B (EP IMPURITY)
4Carbamoylpyridine
4Pyridinecarboxamide
Pyridine4carboxamide
gammaPyridinecarboxamide
ISONIACINAMIDE [INCI]
vfqxvtodmymsmj-uhfffaoysa-n
1453-82-3
pyridine-4-carboxamide
4-Carbamoylpyridine
Isonicotinic acid amide
MFCD00006432
4H3BH6YX9Q
ISN
Isonicotinate amide
4PyrCON
4-carbamoyl-pyridine
pyridine 4-carboxamide
4-Pyridine-carboxamide
pyridine, 4-carbamoyl-
isonicotinamide : form I
SCHEMBL44995
CHEMBL271717
NSC82353
STR00561
Tox21_200230
STL183248
AKOS005067580
CS-W013559
FI01307
HY-W012843
Isonicotinamide, ReagentPlus(R), 99%
NCGC00248572-01
NCGC00257784-01
PD065622
SY018471
CAS-1453-82-3
DB-014829
I0135
NS00024733
C02421
D70516
EN300-370555
Isonicotinamide, Vetec(TM) reagent grade, 98%
A808358
Q192429
BRD-K37606513-001-01-4
Z33546454
F0001-0518