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2-Aminopyrimidine

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Identification
Molecular formula
C4H5N3
CAS number
109-12-6
IUPAC name
pyrimidin-2-amine
State
State

2-Aminopyrimidine is a solid at room temperature.

Melting point (Celsius)
63.00
Melting point (Kelvin)
336.15
Boiling point (Celsius)
212.00
Boiling point (Kelvin)
485.15
General information
Molecular weight
95.11g/mol
Molar mass
95.1110g/mol
Density
1.1290g/cm3
Appearence

2-Aminopyrimidine typically appears as a white or off-white crystalline solid.

Comment on solubility

Solubility of Pyrimidin-2-amine

Pyrimidin-2-amine, known for its aromatic ring structure, exhibits intriguing solubility characteristics that can vary significantly based on the solvent used. This compound is generally considered to be:

  • Soluble in water: Pyrimidin-2-amine has a moderate solubility in water due to the presence of the amino group, which can form hydrogen bonds with water molecules.
  • Soluble in organic solvents: It demonstrates good solubility in polar organic solvents such as methanol and ethanol, owing to its ability to engage in dipole-dipole interactions.
  • Less soluble in non-polar solvents: Conversely, pyrimidin-2-amine's solubility in non-polar solvents is quite poor, which is typical for polar molecules.

It is essential to highlight that the solubility of pyrimidin-2-amine can be influenced by several factors, including temperature and pH of the solution. For instance:

  • Increased temperature: Higher temperatures generally enhance solubility.
  • Adjustments in pH: The amino group can gain or lose protons depending on the pH, which may either stabilize the solute in solution or render it less soluble.

Overall, understanding the solubility of pyrimidin-2-amine is crucial for its applications in medicinal chemistry and various synthetic processes, as it affects the compound's reactivity and bioavailability.

Interesting facts

Interesting Facts about Pyrimidin-2-amine

Pyrimidin-2-amine is a fascinating compound that belongs to the class of heterocyclic aromatic amines. This compound plays a significant role in various fields of chemistry and biochemistry. Here are some intriguing aspects:

  • Structural Importance: Pyrimidin-2-amine has a pyrimidine ring that serves as a crucial building block in the synthesis of several important compounds, including pharmaceuticals and agrochemicals.
  • Biological Activity: This compound is often researched for its potential biological activities. It has been studied for its ability to inhibit specific enzymes, which could lead to the development of novel therapeutics.
  • Versatile Precursor: Pyrimidin-2-amine can be used as a precursor in the synthesis of nucleobases and other nitrogen-containing heterocycles, essential components of nucleic acids. This highlights its significance in molecular biology.
  • Research Applications: Scientists have examined pyrimidin-2-amine for its anti-cancer, anti-viral, and anti-inflammatory properties, making this compound of high interest in medicinal chemistry.
  • Derivative Development: The modification of pyrimidin-2-amine leads to a variety of derivatives, each with distinct properties and potential applications in drug design and molecular research.

In conclusion, pyrimidin-2-amine is not just a simple heterocyclic compound; it is a vital player in the ongoing quest for new medicinal agents and plays a fundamental role in biochemical research. As stated by renowned chemist Robert H. Grubbs, "The beauty of chemistry lies in the connections we forge through our understanding of compounds like pyrimidin-2-amine."

Synonyms
2-AMINOPYRIMIDINE
pyrimidin-2-amine
109-12-6
2-Pyrimidinamine
Aminopyrimidine
Pyrimidin-2-ylamine
2-Pyrimidiylamine
Pyrimidine, 2-amino-
2-Pyridiylamine
1,2-Dihydro-2-iminopyrimidine
2-amino-pyrimidine
NSC 1912
EINECS 203-648-4
Pyrimidinamine
OB8I17P2G4
2(1H)-Pyrimidinimine (9CI)
153824-54-5
CHEBI:38618
AI3-24128
NSC-1912
Pyrimidine, 1,2-dihydro-2-imine-
MFCD00006089
2(1H)-Pyrimidinimine, (E)- (9CI)
2(1H)-Pyrimidinimine, (Z)- (9CI)
CHEMBL88580
DTXSID70870459
176773-04-9
176773-05-0
PYRIMIDINE, 1,2-DIHYDRO-2-IMINO-
SULFADIAZINE IMPURITY A [EP IMPURITY]
551920-04-8
amino pyrimidine
SULFADIAZINE IMPURITY A (EP IMPURITY)
iminopyrimidine
pyrimidyl amine
2Pyrimidinamine
amino-pyrimidine
2Pyrimidiylamine
Pyrimidin2ylamine
2-Aminpirimidina
2-aminopirimidina
Pyrimidin-2-amine; Sulfadiazine Imp. A (Pharmeuropa); Sulfadiazine Impurity A
2-amino pyrimidine
pyrimidine-2-amine
LGA
Pyrimidine, 2amino
pyrimidin-2-yl-amine
27043-39-6
Sulfadiazine Impurity A
2-Aminopyrimidine, 97%
1,2Dihydro2iminopyrimidine
UNII-OB8I17P2G4
Pyrimidine, 1,2dihydro2imino
DTXCID40818181
NSC1912
BDBM50354823
STK317800
AKOS000119323
Pyrimidine, 1,2dihydro2imino (7CI)
CS-W020110
FA34676
MB00175
AC-15596
AS-13594
HY-41340
Pyrimidine, 1,2-dihydro-2-imine-(7CI)
DB-015939
DB-347327
A0412
NS00004461
EN300-17309
2-Aminopyrimidine, Vetec(TM) reagent grade, 97%
A801969
Q27117919
F3329-0410
Sulfadiazine impurity A, European Pharmacopoeia (EP) Reference Standard
203-648-4