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2-Aminoquinoline

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Identification
Molecular formula
C9H8N2
CAS number
580-20-1
IUPAC name
quinolin-2-amine
State
State

At room temperature, 2-Aminoquinoline is in a solid state, usually in the form of crystals or powder.

Melting point (Celsius)
67.00
Melting point (Kelvin)
340.15
Boiling point (Celsius)
279.00
Boiling point (Kelvin)
552.15
General information
Molecular weight
144.17g/mol
Molar mass
144.1730g/mol
Density
1.1932g/cm3
Appearence

2-Aminoquinoline typically appears as a pale yellow crystalline solid. Its crystalline structure can range in form depending on the specific processing and purity of the sample.

Comment on solubility

Solubility of Quinolin-2-amine

Quinolin-2-amine, also known as 2-aminoquinoline, has distinct solubility characteristics that are important to consider. This compound exhibits a moderate level of solubility in various solvents, which can be summarized as follows:

  • Water: Quinolin-2-amine has limited solubility in water, primarily due to its hydrophobic quinoline ring structure. Hydrogen bonding potential exists from the amine group, yet it does not sufficiently overcome the hydrophobic character.
  • Organic Solvents: It is more soluble in organic solvents such as ethanol and methanol. This property is advantageous for reactions and applications that require organic media.
  • pH Effect: The solubility of quinolin-2-amine can be influenced by pH; under more basic conditions, deprotonation of the amine group may enhance its solubility in aqueous solutions.

In practical applications, understanding the solubility behavior of quinolin-2-amine is crucial for compound formulation and its use in various chemical reactions. As with many amines, its solubility profile dictates its reactivity and potential applications in different fields.

Interesting facts

Interesting Facts about Quinolin-2-amine

Quinolin-2-amine, often referred to in scientific circles as an important derivative of quinoline, plays a significant role in various fields of research. Here are some engaging insights into this intriguing compound:

  • Biological Significance: Quinolin-2-amine is known for its potential biological activities, particularly as an anti-cancer agent. Researchers are exploring its derivatives for their ability to inhibit tumor growth.
  • Pharmacological Applications: The compound has garnered attention for its potential applications in drug discovery, especially within the realm of anti-infective agents.
  • Synthesis Versatility: It can be synthesized through various methods, including the rearrangement of heterocycles, making it a versatile building block in organic synthesis.
  • Building Block for Pharmaceuticals: Quinolin-2-amine is utilized in the synthesis of a variety of pharmaceuticals with therapeutic properties, showcasing its importance in medicinal chemistry.
  • Research Opportunities: As researchers delve into the properties of quinolin-2-amine, numerous avenues for investigations open up regarding its efficacy and mechanisms of action.

"The exploration of quinolin-2-amine expands the boundaries of what we know about potential therapeutic agents."

In conclusion, quinolin-2-amine is more than just a simple aromatic amine; it holds a treasure trove of possibilities in medicinal chemistry and biological research. Its role as a precursor in the synthesis of complex molecules and its potential health benefits make it a compound of interest for scientists and pharmacologists alike.

Synonyms
2-AMINOQUINOLINE
quinolin-2-amine
580-22-3
2-Quinolinamine
Quinoline, 2-amino-
2-amino-quinoline
2-Quinolinylamine
CCRIS 1677
EINECS 209-458-8
GR9M8HW75Z
NSC 57739
NSC 58387
BRN 0113163
NSC-57739
NSC-58387
DTXSID2060381
5-22-10-00220 (Beilstein Handbook Reference)
1,2-DIHYDRO-2-IMINO-QUINOLINE
DTXCID5042297
Quinolinamine
101772-05-8
quinolin-2-ylamine
MFCD00038079
139265-95-5
31135-62-3
2(1H)-Quinolinimine(9CI)
CHEMBL61236
quinolimine
amino-quinoline
a-Aminoquinoline
2ohl
quinoline-2-amine
2AQ
2-Aminoquinoline 1
2-Quinolinamine, 9CI
2-Aminoquinoline, 97%
UNII-GR9M8HW75Z
SCHEMBL38775
1,2-Dihydroquinolin-2-imine
2-imino-1,2-dihydroquinoline
SCHEMBL1146984
BDBM14322
CHEBI:184668
HMS1719H05
BCP30417
NSC57739
NSC58387
BBL100884
STL554678
AKOS000279069
CS-W007524
HY-W007524
PS-4207
SB67709
2-Aminoquinoline pound>>2-Quinolinamine
NCGC00188269-01
AC-13271
PD093540
SY019963
DB-005975
A0417
A8247
NS00033837
EN300-10204
A831703
AC-907/25014242
Q209310
Z56347237