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3-Hydroxyquinoline

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Identification
Molecular formula
C9H7NO
CAS number
580-17-6
IUPAC name
quinolin-3-ol
State
State

At room temperature, 3-Hydroxyquinoline is a solid. It exists as yellow crystalline structures which react and dissolve in many solvents, indicating its functionality and use in various reactions and experiments.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
305.00
Boiling point (Kelvin)
578.15
General information
Molecular weight
145.16g/mol
Molar mass
145.1610g/mol
Density
1.1887g/cm3
Appearence

3-Hydroxyquinoline typically appears as a yellow crystalline solid. It can have a slight greenish tint due to impurities or exposure to light. The crystals are usually small and needle-like or plate-like in structure. The compound may also be available in powder form.

Comment on solubility

Solubility of Quinolin-3-ol

Quinolin-3-ol is a fascinating organic compound characterized by its unique chemical structure and solubility properties. When discussing the solubility of quinolin-3-ol, several key points come to light:

  • Polar and Nonpolar Characteristics: Quinolin-3-ol features a hydroxyl group (–OH) that enhances its polar nature. This polarity allows it to interact well with polar solvents.
  • Solvents: It is soluble in water and various organic solvents, such as:
    • Ethyl alcohol
    • Acetone
    • Dichloromethane
  • Temperature Effects: Increased temperature generally enhances the solubility of quinolin-3-ol in solvents, demonstrating typical behavior of many organic compounds.
  • Ethanol and Water Mixture: A combination of ethanol and water provides an optimal solvent system for dissolving quinolin-3-ol completely.

In summary, the solubility of quinolin-3-ol can be considered moderate to high in polar solvents, significantly influenced by temperature and the nature of the solvent mixture. Its ability to dissolve in both aqueous and organic environments underscores its versatility in chemical applications.

Interesting facts

Interesting Facts about Quinolin-3-ol

Quinolin-3-ol, a fascinating compound, belongs to the class of heterocyclic aromatic compounds. Its unique structure and functional groups make it an intriguing subject of study:

  • Bioactive Properties: Quinolin-3-ol exhibits notable biological activities, including antimicrobial, antiviral, and anti-inflammatory effects. Research has shown it to potentially inhibit various pathogens, making it a compound of interest in medicinal chemistry.
  • Synthesis Routes: This compound can be synthesized through several methods, including condensation of aniline and 2-carboxylic acids or through chemical modifications of other quinoline derivatives. Its synthetic versatility allows for tailored applications in various fields.
  • Applications in Drug Development: Due to its therapeutic potentials, quinolin-3-ol is being explored as a scaffold for the development of new pharmaceuticals. Its ability to act on different biological targets opens the door for designing novel drugs.
  • Role in Natural Products: Quinolin-3-ol is often found in various natural products, including those derived from plants. Its presence in nature adds to its importance in understanding biosynthetic pathways and ecological interactions.
  • Research Interest: Ongoing research aims to elucidate the mechanisms behind its bioactivity and to discover new derivatives that could enhance its efficacy and reduce potential side effects.

In summary, quinolin-3-ol is not just another organic compound; it holds potential that stretches across different areas of chemistry and pharmacology, embodying the essence of how small molecular changes can lead to significant biological impacts. As one researcher aptly noted, "Understanding compounds like quinolin-3-ol is essential for bridging the gap between traditional chemistry and modern medicinal applications." This underscores the relevance of ongoing studies in this exciting field.

Synonyms
3-Hydroxyquinoline
Quinolin-3-ol
3-QUINOLINOL
3-Quinolol
CCRIS 4328
EINECS 209-456-7
UNII-12PZ582CI0
BRN 0113185
12PZ582CI0
DTXSID00206727
5-21-03-00224 (Beilstein Handbook Reference)
DTXCID30129218
iqqdnmhuolmlnj-uhfffaoysa-n
580-18-7
MFCD00169018
3-Quinolol; 3-Quinolinol
3-hydroxychinolin
Quinolin-3-o1
3-hydroxy-quinoline
quinoline, 3-hydroxy-
Oprea1_711388
SCHEMBL133799
3-hydroxyquinoline, AldrichCPR
CHEMBL3236920
ALBB-021965
BCP20129
BBL104199
STL558030
AKOS003602545
CS-W008203
SB67484
AC-22551
AS-18424
SY009024
DB-006469
NS00033835
Q0094
EN300-98107
AC-907/34120040
AC-907/34120041
AE-907/30839031
Q27251431
Z1255419538