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5-Aminoquinoline

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Identification
Molecular formula
C9H8N2
CAS number
578-66-5
IUPAC name
quinolin-5-amine
State
State

At room temperature, 5-Aminoquinoline is in a solid state.

Melting point (Celsius)
96.00
Melting point (Kelvin)
369.15
Boiling point (Celsius)
312.00
Boiling point (Kelvin)
585.15
General information
Molecular weight
144.17g/mol
Molar mass
144.1880g/mol
Density
1.1180g/cm3
Appearence

5-Aminoquinoline appears as a beige to brown solid. It is typically found in crystalline form and is known for its characteristic aromatic odor.

Comment on solubility

Solubility of Quinolin-5-amine

Quinolin-5-amine, with a chemical formula represented as C9H8N2, exhibits noteworthy properties concerning its solubility:

  • Solvent Preference: Quinolin-5-amine is generally soluble in polar organic solvents such as ethanol and methanol. This suggests a degree of interaction between the molecule and polar environments.
  • Solubility in Water: Its solubility in water is limited, making it more suitable for reactions in organic phases or non-aqueous systems.
  • Impact of Functional Groups: The presence of the amine group can enhance hydrogen bonding capabilities, which might influence the solubility in various solvent systems.

In considering its practical applications, it is essential to note that temperature and pH can also significantly affect the solubility of quinolin-5-amine, which is critical in various chemical processes and formulations.

Overall, due to its solubility characteristics, quinolin-5-amine is best handled in environments where polar solvents dominate, ensuring effective usage in synthetic methodologies.

Interesting facts

Quinolin-5-amine: An Intriguing Organic Compound

Quinolin-5-amine is a fascinating compound that belongs to the quinoline family, a class of aromatic compounds known for their nitrogen-containing ring structure. Here are some intriguing aspects of this compound:

  • Chemical Structure: The unique structure of quinolin-5-amine features a quinoline ring with an amino group attached at the 5-position, which influences its reactivity and properties significantly.
  • Biological Importance: Compounds related to quinolin-5-amine are often investigated for their potential pharmacological activities. They may exhibit antimicrobial, antitumor, and anti-inflammatory properties, making them of interest in medicinal chemistry.
  • Fluorescence: Quinolin-5-amine can be utilized in the development of fluorescent probes due to its ability to form highly fluorescent derivatives, which are essential in biological imaging and diagnostics.
  • Synthetic Pathways: Researchers have developed various synthetic routes to produce quinolin-5-amine, often exploring reactions that include cyclization or condensation, showcasing the versatility and reactivity of the compound.
  • Applications in Research: This compound serves as a useful building block in organic synthesis and is often used in the construction of more complex organic molecules, highlighting its importance in chemical research.

With its unique properties and potential applications, quinolin-5-amine continues to capture the interest of chemists and researchers alike, representing a bridge between organic chemistry and biological functions. Its role in the development of novel therapeutics underscores the significance of studying compounds like quinolin-5-amine in the quest for new medicinal agents.

Synonyms
5-AMINOQUINOLINE
611-34-7
5-Quinolinamine
Quinoline, 5-amino-
5-Quinolylamine
CCRIS 1680
EINECS 210-266-1
YYJ34Z13SH
NSC 27982
BRN 0114479
NSC-27982
AMINOQUINOLINE, 5-
(QUINOLIN-5-YL)AMINE
DTXSID80209978
5-22-10-00297 (Beilstein Handbook Reference)
NSC-170619
5Quinolinamine
5Quinolylamine
Quinoline, 5amino
5-Quinolinamine (9CI)
DTXCID30132469
210-266-1
quinolin-5-amine
Quinolin-5-ylamine
146614-41-7
5-amino-quinoline
MFCD00006797
CHEMBL100194
UNII-YYJ34Z13SH
5- aminoquinoline
5-AMINO-QUINOLINE, 98+%
5-Aminoquinoline, 97%
WLN: T66 BNJ GZ
BIDD:GT0664
SCHEMBL115674
HMS1763O15
ALBB-021975
NSC27982
STR02112
BDBM50520384
STK328163
AKOS000108491
AC-2879
CS-W001604
FA15583
HY-W001604
PS-4993
SB67466
NCGC00341395-01
PD147992
SY003215
DB-029059
A0959
NS00034580
EN300-30137
AB00443836-04
Q27294793
Z56919160
F2124-0039
InChI=1/C9H8N2/c10-8-4-1-5-9-7(8)3-2-6-11-9/h1-6H,10H