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8-Hydroxyquinoline

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Identification
Molecular formula
C9H7NO
CAS number
148-24-3
IUPAC name
quinolin-6-ol
State
State

At room temperature, 8-hydroxyquinoline is in a solid state. It is commonly found in crystalline form when not in solution.

Melting point (Celsius)
75.00
Melting point (Kelvin)
348.15
Boiling point (Celsius)
267.00
Boiling point (Kelvin)
540.15
General information
Molecular weight
145.16g/mol
Molar mass
145.1620g/mol
Density
1.3440g/cm3
Appearence

8-Hydroxyquinoline is characterized by a crystalline, solid appearance. It typically appears as a light yellow powder or crystalline solid in pure form.

Comment on solubility

Solubility of Quinolin-6-ol

Quinolin-6-ol, also known as 6-hydroxyquinoline, exhibits intriguing solubility characteristics that are vital for its applications in various fields. This compound generally demonstrates:

  • Moderate solubility in water: Quinolin-6-ol's hydroxyl group enhances its hydrophilicity, but it is still more soluble in organic solvents.
  • Substantial solubility in organic solvents: It tends to dissolve well in solvents such as ethanol, methanol, and dichloromethane. This solubility can be attributed to its aromatic structure, which facilitates interactions with non-polar solvents.
  • pH-dependency: The solubility can be influenced by the pH of the solution, as the ionization of the hydroxyl group affects the overall solubility properties. An increase in pH might enhance solubility due to the deprotonation of the phenol group, leading to greater dispersibility in aqueous solutions.

Overall, Quinolin-6-ol's solubility profile is critical for its utility in synthesis, biological studies, and as a building block in the design of various pharmaceuticals and agrochemicals. As with many compounds, it’s essential to consider the environmental conditions when predicting its behavior in solution.

Interesting facts

Interesting Facts About Quinolin-6-ol

Quinolin-6-ol is a fascinating compound that belongs to the class of heterocyclic aromatics, specifically the quinoline derivatives. This compound is of significant interest in various scientific fields due to its unique chemical structure and versatile applications. Here are some intriguing aspects of quinolin-6-ol:

  • Versatile Applications: Quinolin-6-ol is employed as a building block in organic synthesis and can serve as a precursor for various pharmaceuticals and agrochemicals.
  • Biological Activity: Compounds containing the quinoline structure, including quinolin-6-ol, have been studied for their potential biological activities, including antimicrobial and antitumor properties.
  • Fluorescent Properties: Quinolin-6-ol displays fluorescent characteristics, making it useful in analytical chemistry applications, such as fluorescence microscopy and sensing technologies.
  • Research Significance: The compound has been a subject of research for its role in chelation processes, engaging with metal ions to form coordination complexes that can be useful in catalysis.
  • Structural Insights: Quinolin-6-ol showcases interesting electronic properties due to its resonance structure, which contributes to its reactivity and interaction with other compounds.

As a chemist or chemistry student, exploring quinolin-6-ol can lead to valuable insights into the interactions and applications of heterocyclic compounds in modern science. The blend of its chemical properties and potential uses makes it a remarkable compound worthy of study.

Synonyms
6-Hydroxyquinoline
Quinolin-6-ol
6-QUINOLINOL
6-Chinolinol
CCRIS 4331
NSC 26343
EINECS 209-454-6
95RU6I7UXL
BRN 0113196
CHEBI:48994
NSC-26343
UNII-95RU6I7UXL
HYDROXYQUINOLINE, 6-
CCRIS-4331
OVYWMEWYEJLIER-UHFFFAOYSA-
DTXSID40206726
5-21-03-00244 (Beilstein Handbook Reference)
DTXCID70129217
inchi=1/c9h7no/c11-8-3-4-9-7(6-8)2-1-5-10-9/h1-6,11h
ovywmewyejlier-uhfffaoysa-n
580-16-5
1H-1,6-Epoxyquinoline
MFCD00047611
quinoline-6-ol
6-hydroxy-chinolin
6-hydroxy-quinoline
quinoline, 6-hydroxy-
6-HYDROXYQUINOLINE (6-QUINOLINOL)
6-Hydroxyquinoline, 95%
6-Quinolinol (8CI,9CI)
SCHEMBL112289
CHEMBL1908053
NSC26343
BBL103626
CX1058
STL557436
AKOS000277413
AC-5108
CS-W007818
PS-3719
SB67457
BP-13160
SY003116
6-Quinolinol, technical, >=95% (HPLC)
DB-031619
NS00033834
Q0060
EN300-52757
A26208
AC-907/25014237
2,6-Dihydroxyquinoline;6-Hydroxy-2(1h)-quinolinone
Q27121428
1H-1,6-Epoxyquinoline; 6-Hydroxyquinoline; NSC 26343
F0001-1515
Z759294450