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8-Aminoquinoline

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Identification
Molecular formula
C9H8N2
CAS number
578-66-5
IUPAC name
quinolin-8-amine
State
State

8-Aminoquinoline is typically found in a solid state at room temperature. It often takes the form of yellow crystalline powders, which are stable under standard conditions.

Melting point (Celsius)
72.00
Melting point (Kelvin)
345.00
Boiling point (Celsius)
267.00
Boiling point (Kelvin)
540.00
General information
Molecular weight
144.19g/mol
Molar mass
144.1870g/mol
Density
1.1760g/cm3
Appearence
8-Aminoquinoline is characterized by its pale yellow crystalline appearance, which can appear nearly white in certain conditions. This compound may also be described to have a more granular or powdery form depending on its physical handling.
Comment on solubility

Solubility of Quinolin-8-amine

Quinolin-8-amine, with the chemical formula C9H8N2, showcases notable characteristics regarding its solubility. Understanding the solubility profile of this compound is essential for its application in various fields.

Solubility Characteristics

Here are some key aspects of the solubility of quinolin-8-amine:

  • Solvent Dependency: Quinolin-8-amine is generally soluble in polar solvents such as ethanol and dimethyl sulfoxide (DMSO), making these substances suitable for dissolving the compound.
  • Water Solubility: The solubility of quinolin-8-amine in water is relatively low, which can limit its use in aqueous solutions.
  • pH Influence: The solubility may be impacted by the pH of the solution, with higher solubility in acidic conditions due to protonation of the amine group.

As a general trend, compounds like quinolin-8-amine demonstrate that:

  • Increased polarity often correlates with greater solubility in polar solvents.
  • Hydrophobic regions in organic compounds may hinder solubility in water.

In summary, the solubility of quinolin-8-amine is influenced significantly by the nature of the solvent and the pH environment, making it a fascinating compound for further research in chemical applications.

Interesting facts

Interesting Facts About Quinolin-8-amine

Quinolin-8-amine, also known as 8-aminoquinoline, is a fascinating compound that holds significant importance in both organic chemistry and medicinal applications. Here are some intriguing points about this compound:

  • Historical Significance: Quinolin-8-amine was first synthesized in the early 20th century, and since then, it has played a vital role in various fields, particularly in pharmacology.
  • Medicinal Uses: This compound is noted for its potential in treating malaria and other infectious diseases, making it a valuable asset in the development of antimalarial drugs.
  • Research Potential: Studies have shown that quinolin-8-amine derivatives exhibit properties that might be useful in combating different types of cancer, showcasing their versatility in therapeutic applications.
  • Key Intermediary: Quinolin-8-amine functions as a key building block in the synthesis of more complex organic compounds, aiding in the creation of new materials and pharmaceuticals.
  • Collaboration of Fields: The compound's unique structure has made it a subject of interest not only in chemistry but also in biology and material science, fostering interdisciplinary research.

To quote a noted chemist, "The discovery of new compounds often opens doors to previously unimagined applications." Quinolin-8-amine is a representation of this truth, showcasing how a single compound can have varied roles across different domains of science.

As research continues to evolve, the future of quinolin-8-amine and its derivatives shows promise, potentially leading to groundbreaking discoveries that could help address global health concerns.

Synonyms
8-AMINOQUINOLINE
578-66-5
quinolin-8-amine
8-Quinolinamine
8-Quinolylamine
Quinoline, 8-amino-
quinolin-8-ylamine
8-quinolinylamine
CCRIS 1683
NSC 7933
EINECS 209-427-9
U34EAV21TG
NC 066
WR 6920
BRN 0114474
AMINOQUINOLINE, 8-
AMINOQUINOLINE [VANDF]
DTXSID4060369
8-AMINOQUINOLINE [VANDF]
5-22-10-00316 (Beilstein Handbook Reference)
8Quinolinamine
8Quinolylamine
Quinoline, 8amino
DTXCID8042262
CHEBI:36709
DTXSID701055665
WR006026
WR-006026
209-427-9
aminoquinoline
MFCD00006809
8-Aminoquinoline, 98%
NSC-7933
AS-232
UNII-U34EAV21TG
8-amino quinoline
8-amino-quinoline
quinolin-8-yl-amine
cid_11359
BIDD:GT0148
CHEMBL99932
SCHEMBL159694
8-Quinolinamine;8-Quinolylamine
BDBM32144
WREVVZMUNPAPOV-UHFFFAOYSA-
NSC7933
ALBB-023501
BCP32569
STK344576
AKOS000108492
CS-W007317
FA03339
HY-W007317
PS-5383
SB40763
SDCCGMLS-0065843.P001
NCGC00184185-01
NCGC00184185-02
AC-10209
BP-13199
SY012863
DB-012217
A0419
NS00033804
EN300-10405
MLS-0065843.0001
AB00375631-02
US9394254, 18
A831646
AC-907/25014399
Q4644259
F2190-0534
InChI=1/C9H8N2/c10-8-5-1-3-7-4-2-6-11-9(7)8/h1-6H,10H2
Q8A